Ask about this productRelated genes to: ERBB3 antibody
- Gene:
- ERBB3 NIH gene
- Name:
- erb-b2 receptor tyrosine kinase 3
- Previous symbol:
- LCCS2
- Synonyms:
- HER3
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-15
- Date modifiied:
- 2019-04-23
Related products to: ERBB3 antibody
Related articles to: ERBB3 antibody
- While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha-L-fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)-mediated α-1,3-fucosylation of ErbB3 at Asn437, FUCA2 safeguarded ErbB3-ErbB2 heterodimerization to promote ErbB3 activation and sustain persistent AKT signaling. Active AKT prevented p53 protein stabilization in TP53-wild-type LUAD cells and inhibited p27 protein accumulation in TP53-mutant LUAD cells, thereby counteracting senescence and supporting malignant growth. Notably, low-dose Capivasertib, an AKT inhibitor targeting tumors with PIK3CA/AKT1/PTEN mutation(s), induced senescence selectively in FUCA2-high LUAD irrespective of PIK3CA/AKT1/PTEN/TP53 mutational status, and its combination with the nutraceutical senolytic procyanidin C1 achieved potent and low-toxicity suppression of LUAD across multiple preclinical models. Together, our results uncover the FUCA2-ErbB3 fucosylation-AKT pathway as a central regulator of senescence and propose a FUCA2-guided drug repurposing strategy for LUAD. - Source: PubMed
Publication date: 2026/06/16
Chen LuGuo JintaoLi FeiGao MingjieLi RunyangHuang ZhaozhangZheng YaolinGao ChunyiHou JihuanYu QiangZheng BowenChen XuemeiZhang WenqingHong XiaotingZheng YaliWang DaxuanLi QiyuanHu TianhuiZhan Yan-Yan - Neural structures are widely distributed in the oral and maxillofacial region and play important roles in the progression of head and neck squamous cell carcinoma (HNSCC). Herein, we delineate the dynamic transition trajectory of Schwann cells during cancer initiation and progression and identify a Schwann cell subpopulation, HLA-DR Schwann cell, that induced by cancer cells and enriched as HNSCC progression. With the in vitro coculture assay and a Schwann cell-targeted gene engineering in vivo model, we demonstrate that Schwann cells are educated by HNSCC cells via the NRG1/ERBB3 axis, activate the downstream JAK/STAT signaling pathway, and acquire immunoregulatory and protumor phenotypes. Furthermore, HLA-DR Schwann cells are found to secrete CCL2 to induce a protumor macrophage subpopulation (Il1β. Mph), which promotes CD4 T cell accumulation via CXCL10/CXCR3 for HLA-DR Schwann cells and assists them in shaping the cancer-neuron-immune niche and facilitating HNSCC progression. The tumor suppression effects of CCL2 inhibitor (Pirfenidone) and CXCR3 inhibitor (AMG487) are validated in the orthotopic tumor model. Our findings reveal the mechanism of how HLA-DR Schwann cells generate cancer-neuron-immune niche, provide insights into tumor neurology, and lay foundations for therapeutics development for HNSCC patients. - Source: PubMed
Publication date: 2026/06/15
Meng XiaoyanLiu ZhonglongZhang ShijianGan LuomanCao LirenSun JingjingZhang LingfangHe Yue - inhibitors such as sotorasib have improved outcomes in -positive nonsquamous NSCLC; however, the underlying mechanisms remain incompletely understood. - Source: PubMed
Publication date: 2026/03/28
Senoo SatoruTakata KoheiMatsumori ShunsukeBaba TakahiroSugisaki YukaOmori HirokiMatsuura HiroakiMatsuura YumiOmote RikaIchihara EikiOkada Toshiaki - Endometrial cancer is a common gynecological malignancy, and elucidating its molecular basis may provide new clues for targeted intervention. This study investigated the role of ERBB3 in endometrial cancer cells and explored whether Ras-ERK/MAPK signaling is involved in ERBB3-mediated regulation. - Source: PubMed
Publication date: 2026/05/28
Liu YuanlinLi HuLi XiaofengLi MingyuanLi Yiran - Thymic epithelial tumors (TETs), which include thymomas and thymic carcinomas (TCs), are the most common neoplasms of the anterior mediastinum. To develop more effective therapeutics, it is necessary to better understand their molecular characteristics. - Source: PubMed
Publication date: 2026/06/08
Kim ChulAdeyelu TolulopeManiar RohanFarrell AlexZaemes JacobSolzak JeffreyHancock BradleyElliott AndrewMicaily IdaNagasaka MisakoNieva JorgeBorghaei HosseinHalmos BalazsMa Patrick CRadovich MilanBadve Sunil SLoehrer Patrick J