Ask about this productRelated genes to: ANGPT1 protein
- Gene:
- ANGPT1 NIH gene
- Name:
- angiopoietin 1
- Previous symbol:
- -
- Synonyms:
- KIAA0003, Ang1
- Chromosome:
- 8q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-10
- Date modifiied:
- 2015-08-28
Related products to: ANGPT1 protein
Related articles to: ANGPT1 protein
- Behçet disease (BD) is an inflammatory disorder with significant ocular involvement. Angiopoietins regulate vascular stability, while EphrinB2/EphB4 interactions are essential for retinal neovascularization and endothelial behavior. Endocan, a marker of endothelial activation, contributes to inflammatory processes by mediating leukocyte migration. This cross-sectional study investigates the role of angiopoietins, EphrinB2/EphB4 signaling, and endocan in the development of active uveitis in BD patients. We recruited 29 BD patients with active eye involvement (group 1), 31 BD patients without eye involvement (group 2), and 30 healthy controls (group 3). Serum tyrosine protein kinase receptor (Tie-2), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), EphrinB2, EphB4, and endocan levels were determined by the enzyme-linked immunosorbent assay method. A statistically significant difference was found between the Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan levels of the 3 different groups in the study (P < .05). Between the patients with panuveitis and patients with only posterior or anterior uveitis, serum Ang-1 (P < .001), Tie-2 (P < .001), EphrinB2 (P < .001), EphB4 (P = .001), and endocan (P = .002) levels had statistically significant differences. The highest and significant correlation was found between EphrinB2 and EphB4 (r = 0.931, P < .001). This was followed by a high level of significant correlation between Ang-1 and Ang-2 (r = -0.845, P < .001). In the group with active uveitis, EphB4 (r = -0.774), Ang-2 (r = -0.763), and Tie-2 (r = -0.701) were negatively and highly significantly correlated with best corrected visual acuity (P < .001). Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan regulate vascular stability, retinal neovascularization, and inflammation, potentially contributing to BD-associated uveitis. These findings could have important implications for the diagnosis and management of ocular involvement of BD. - Source: PubMed
Gökçek Barutcigil BetülÇinici EmineLaloglu Esra - Follicular development in laying hens requires a balance between angiogenesis and redox status, yet their synergistic interplay across different production levels and physiological stages remains unclear. This study compared high-production (HP) and low-production (LP) hens at 50 and 75 weeks of age using morphological, antioxidant, angiogenic, and transcriptomic analyses. An acute tBHP-induced oxidative stress model was further employed to elucidate the temporal coupling between these systems. - Source: PubMed
Publication date: 2026/05/03
Qin KailongGao MingluLiu XiaoyingLiu YanliYang XiaojunYang Jiantao - This study aimed to determine whether fatty acids (FAs) may affect the function of the early porcine placenta. First, the expression of FA transporters (CD36, SLC27A) in conceptuses and placentae of days 10-11, 12-13, 15-16, 18-20, 25, and 30 pregnant gilts (n = 5-8 per group) was examined using Real-time PCR, Western blot, and immunohistochemistry. Then, primary trophoblast (pTr) cells from days 15-16 conceptuses were exposed to n-6 and n-3 polyunsaturated FAs (PUFAs) to study prostaglandin (PG) synthesis and the expression of genes related to FA action, angiogenesis, steroidogenesis, and lipid transport. Furthermore, pTr cell proliferation and adhesion in response to PUFAs were determined colorimetrically. Increased mRNA expression of CD36, SLC27A1, and SLC27A2 was detected in days 18-25 placentae compared with days 10-13 conceptuses. SLC27A4 and SLC27A6 expression was greater in days 10-11 spherical than in days 15-16 elongated conceptuses. SLC27A1, SLC27A4, and SLC27A6 were localized at the placenta-endometrium interface. PUFAs of n-6 series elevated PGE2 and PGI2 synthesis, whereas n-3 PUFAs stimulated PGE2 but inhibited PGI2 output. All PUFAs up-regulated the mRNA expression of CPT1A, a rate-limiting enzyme of FA β-oxidation. Moreover, docosahexaenoic acid (DHA) increased FABP5, SLC27A4, LDLR (lipoprotein receptor), and proangiogenic ANGPT1 and ANGPTL4 mRNA expression. DHA and arachidonic acid stimulated pTr cell proliferation, while linoleic and eicosapentaenoic acids increased cell adhesion. These results are the first demonstrating dynamic changes of FA transporter expression in peri-implantation conceptuses and developing placentae of the pig and indicate FA uptake by the early placenta. Furthermore, PUFAs may support placenta development by modulating gene expression, increasing PGE2 level, and promoting trophoblast cell viability and adhesion. - Source: PubMed
Publication date: 2026/05/02
Blitek AgnieszkaSzymanska Magdalena - Non-invasive assessment of oocyte quality remains a challenge in assisted reproductive technology (ART). Through their bidirectional communication with the gamete, cumulus cells (CCs) act as a functional mirror of oocyte competence; however, the specific angiogenic signature within this microenvironment is still poorly understood. In the present study, we performed RNA-seq on CCs from healthy oocyte donors and infertile patients, utilizing a multi-pipeline bioinformatic approach (STAR-Cufflinks, TopHat-HTSeq, and HISAT2-StringTie) to establish a high-confidence, exploratory transcriptomic profile. A set of 234 differentially expressed genes (DEGs) consistently identified across pipelines was obtained, with functional enrichment highlighting blood vessel morphogenesis and angiogenesis as primary drivers of transcriptomic divergence between groups. RT-qPCR validation in individual samples confirmed statistically significant differences for (upregulated) and (downregulated) in infertile patients, while other angiogenesis-related genes, including , and , showed consistent but non-significant expression trends, suggesting alterations in angiogenesis-related processes within the follicular microenvironment. These findings support the presence of coordinated angiogenesis-related alterations in cumulus cells and provide a basis for future studies exploring their potential relevance in oocyte competence and ART outcomes. - Source: PubMed
Publication date: 2026/04/11
Baratas AlejandroPérez-Quiroga VictoriaPlanello RosarioAquilino MónicaSerrano MagdalenaCasa Moisés de laFranco-Iriarte YosuRoy Rosa - Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical diagnosis. Here, we perform a genome wide association study meta-analysis including 18,948 individuals of European ancestry and identify 12 genome-wide significant loci across all three biomarkers, eight of them novel. We replicate the association of biomarkers with APOE, CR1, GMNC/CCDC50 and C16orf95/MAP1LC3B. Novel loci include BIN1 for amyloid beta and GNA12, MS4A6A, SLCO1A2 with both total tau and phosphorylated tau 181, as well as additional loci on chr. 8, near ANGPT1 and chr. 9 near SMARCA2. We also demonstrate that these variants have significant association with Alzheimer's disease risk, disease progression and/or brain amyloidosis. The associated genes are implicated in lipid metabolism independent of APOE, coupled with autophagy and brain volume regulation driven by total tau and phosphorylated tau 181 dysregulation. - Source: PubMed
Publication date: 2026/04/21
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