Ask about this productRelated genes to: IRF2 antibody
- Gene:
- IRF2 NIH gene
- Name:
- interferon regulatory factor 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-05-09
- Date modifiied:
- 2016-01-15
Related products to: IRF2 antibody
Related articles to: IRF2 antibody
- Interferon regulatory factor 2 (IRF2) is a transcription factor that prevents skin inflammation in mice and humans but, paradoxically, promotes pyroptosis by upregulating gasdermin D. How IRF2 activates some proinflammatory genes but suppresses inflammation is unclear. We show that skin inflammation in Irf2-deficient mice is driven by IRF1 activation of interferon-stimulated genes (ISGs). Chromatin profiling reveals that IRF1 and IRF2 occupy the same ISG regulatory sites, but as a weaker transcriptional activator, IRF2 limits ISG transcription by IRF1. Toll-like receptor (TLR) signaling favors IRF1-driven transcription by inducing Irf1. In addition, IRF1 recruits the ubiquitin ligase SPOP to ISG sites, resulting in proteasomal degradation of IRF2. This shift from IRF2 to IRF1 occupancy enhances ISG transcription. Collectively, these findings define a hierarchical transcriptional circuit in which IRF2 limits IRF1 activity under homeostatic conditions but is displaced during an immune response, allowing IRF1-dependent gene programs central to innate immunity and autoinflammation. - Source: PubMed
Publication date: 2026/09/22
Cadena CristhianReja RohitBolech EmmaWebster Joshua DKameswaran Vasumathide Simone MarcoChen CynthiaJiang JianHotzel KathyBjornson ChristopherAlegre KamelaTan ZhenyuElsaesser Heidi JNewland RaymondKelly RyanDarmanis SpyrosDaniel BenceBrooks David GDeshpande IshanNewton KimKayagaki NobuhikoDixit Vishva M - The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). - Source: PubMed
Publication date: 2026/09/17
Evans Daniel SMansfield Tyler AMany Gina MSagendorf Tyler JFarsijani SamanehGoodpaster Bret HSparks Lauren MLane Nancy E - Epi-transcriptomic modifications, particularly N4-acetylcytidine (ac4C), and chronic neuroinflammation have emerged as pivotal players in the pathogenesis of Parkinson's disease (PD). However, the specific molecular co-expression patterns linking ac4C RNA modification to neuronal inflammatory responses remains largely uncharted. - Source: PubMed
Publication date: 2026/09/01
Li Yuan - The liver is an immune privileged organ, yet it needs to overcome infections. We aimed to explore the role of the liver-specific microRNA miR-122 in liver immune tolerance. - Source: PubMed
Publication date: 2026/08/29
Gefen MaytalLayani ShannyKlahr EmmaShemuelian ZoharBrandi JohannesJacobs ThomasSteeg ChristianeAdlung LorenzKilian ChristophOrdan MeravGordon OrenAbudi NathalieAbramovitch RinatNevo YuvalElgavish SharonaBenyamini HadarMonin JonathanKhvalevsky Elina ZordeRosenberg NofarMarkezana AureliaYaish DayanaYehezkel Adi SSimerzin AlinaRivkin MilaAmran OsherGoldenberg Daniel SPeled AmnonAxelrod JonathanRachmilewitz JacobHuber SamuelGagliani NicolaSchramm ChristophWeidemann SörenHerkel JohannesCarambia AntonellaSafadi RifaatKhalaileh AbedImam AshrafHeide DanielaHetzer JennyRose-John StefanHeikenwälder MathiasGiladi HillaGalun Eithan - M1 macrophage polarization is a key mechanism in diabetic neuropathic pain (DNP), and interferon regulatory factor 2 (IRF2) has been shown to regulate macrophage polarization. - Source: PubMed
Publication date: 2026/08/26
Liang YueweiNing YaLi XiaomeiFeng PengchengLiu YingyingHuang Youqing