Ask about this productRelated genes to: HOXC10 antibody
- Gene:
- HOXC10 NIH gene
- Name:
- homeobox C10
- Previous symbol:
- HOX3I
- Synonyms:
- -
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1993-02-18
- Date modifiied:
- 2015-08-25
Related products to: HOXC10 antibody
Related articles to: HOXC10 antibody
- This study aimed to investigate whether Astragaloside-Brucea javanica oil nanoemulsion (AS/BJO-NEs) inhibits the malignant progression of oral squamous cell carcinoma (OSCC) and to further explore its potential regulatory mechanisms. - Source: PubMed
Publication date: 2026/05/12
Lai YihanLiu RunqiangZhou LanfeiWan ZhichaoZhan JuanXiong MingqiaoJiang LinWang WeiShao Yisen - Neural progenitor cell (NPC) transplantation is a promising strategy for spinal cord injury repair, as graft-derived neurons can integrate into host circuitry and promote functional recovery. While the brain-regional and dorsoventral identities of NPCs are known to influence graft composition and performance, the importance of axial (rostrocaudal) identity, specifically whether NPCs must be matched to the spinal level of injury, remains poorly understood. To address this, we compared outcomes following transplantation of NPCs isolated from the anterior embryonic spinal cord (A-NPCs) versus the posterior spinal cord (P-NPCs) in a mouse model of C5 cervical dorsal column injury. Following transplantation, NPCs retained their intrinsic molecular axial identities; P-NPC grafts maintained significantly higher expression of the lumbar-associated gene HoxC10 and possessed a higher proportion of Chx10-high V2a neurons compared to A-NPCs. Despite these maintained molecular differences, A-NPC and P-NPC grafts were indistinguishable in neuronal and glial density, axon outgrowth, and their ability to support host axon regeneration, including the corticospinal tract. Long-term behavioral testing and retrograde transsynaptic tracing revealed no significant differences between groups in the recovery of skilled pellet reaching, grip strength, or synaptic integration with host cervical motor circuitry. These findings demonstrate that although transplanted NPCs retain their molecular axial identity in the adult injured environment, this identity is not a primary determinant of anatomical integration or functional outcome. Our findings suggest a degree of plasticity in graft-host interactions and indicate that strict segment-matching is not essential for the efficacy of NPC-based therapies in spinal cord injury. - Source: PubMed
Publication date: 2026/03/11
Smith AshleyDietz ValerieHoppe Joseph DImrie GillianLee GrantLeonards AmyJagrit VipinEvans AbigailGillespie TuckerGottschall BrysonInskeep BenardAmar Kumar PrakruthiFriedrich LoganBlackmore Murray GFarhy-Tselnicker IsabellaDulin Jennifer N - Chicken muscle fibers are classified as oxidative or glycolytic, with distinct metabolic properties that influence meat quality. However, the molecular mechanisms linking fiber type to quality traits remain unclear. This study compared the pectoralis major (PEM) and soleus (SOL) muscles of Guangyuan Gray chickens, revealing significant differences in fiber characteristics and meat quality. Transcriptome analysis identified key pathways─MAPK, PPAR, and calcium signaling─associated with fiber-type variation. The transcription factor HOXC10, enriched in SOL, showed inverse expression to its predicted regulator, miR-6701-3p. Dual-luciferase assays confirmed HOXC10 as a direct target of miR-6701-3p. Functional studies in skeletal muscle satellite cells demonstrated that miR-6701-3p promotes proliferation, inhibits differentiation, and induces fast-twitch fiber formation, while HOXC10 facilitates slow-twitch fiber development. These findings suggest that the miR-6701-3p/HOXC10 axis may contribute to the regulation of muscle fiber types and be linked to muscle fiber characteristics that are associated with meat quality variation. - Source: PubMed
Publication date: 2026/01/21
Zhang DonghaoZhang WeijieWang YufeiTang YuanLin ZhongzhenWang YanChen LiLu LuLiu Yiping - Aging, caused by a variety of exogenous stimuli and internal factors, leads to a gradual and irreversible decline in the function of the organism. The aging process involves complex gene regulation, in which transcription factors may play a key role as core regulatory elements. In this study, the single-cell transcriptome of skin revealed homeobox C10 (HOXC10) as a core element in the transcription factor regulatory network associated with skin aging. In vivo and vitro, the expression of HOXC10 was down-regulated in senescent fibroblasts and aging tissues, and overexpressed HOXC10 delayed cell senescence and skin aging. Mechanistically, HOXC10 targeted the promoter region of frizzled 6 (FZD6) to reduce its expression and therefore activated the Wnt/β-catenin signaling pathway to delay aging. Finally, by using the Connectivity Map approach, we explored simvastatin as a functional mimic of HOXC10 and demonstrated its antiaging ability in vitro and vivo. In conclusion, our results establish the role of HOXC10/FZD6/Wnt signals in skin aging and identify simvastatin as a potential therapeutic strategy to delay aging. - Source: PubMed
Publication date: 2025/11/19
Zhong YunGuo YiMao RuiZhou LeiWang FanMeng XinXiao XinYuan HaonanZhang YifanDeng ZhiliShi WeiWang QianXie HongfuZhang YiyaLi Ji - Calvarial suture skeletal stem cells (Su-SSCs) are a distinct stem cell population for craniofacial bone formation by intramembranous ossification, compared to long bone periosteal SSCs (LB-PSSCs) with endochondral (osteochondrogenic) ossification. However, whether SSC intrinsic or extrinsic factors affect their differentiation process has not been well elucidated. Here, using an inducible -CreER-EGFP;Rosa26-tdTomato mouse model, we observed that endogenous Su-SSCs and their orthotopic transplantation into calvarial injury do not form cartilage intermediates at the injury sites, while the transplantation of LB-PSSCs into LB injury induces osteochondrogenic differentiation, respectively. However, the heterotopic transplantation of Su-SSCs (Su-SSCs into LB injury) showed some surprising findings that the transplanted Su-SSCs acquire new chondrocyte differentiation properties at the LB injury sites, although the heterotopic-transplanted LB-PSSCs maintained their endochondral ossification properties at the calvarial injury sites. Further, a comparative single-cell transcriptomic analysis of LB-PSSCs and Su-SSCs revealed that Su-SSCs express a higher set of anti-chondrogenic genes, such as , while LB-PSSCs highly express chondrogenic , , , and genes. We also found that the heterotopic transplantation of LB-PSSCs into calvarial injury enhances bone healing in vivo. Taken together, these findings suggest that LB-PSSCs have high regenerative capability with invariable endochondral ossification even after the heterotopic transplantation but Su-SSCs are more flexible and regulated by the local bone environment. The transplantation of periosteal SSCs will be a promising method for large craniofacial bone defects. - Source: PubMed
Publication date: 2025/09/26
Solidum JeaYamasaki KoheiJeong YoungjaeOrtinau LauraHeralde FranciscoPark Dongsu