Ask about this productRelated genes to: POLR2I antibody
- Gene:
- POLR2I NIH gene
- Name:
- RNA polymerase II subunit I
- Previous symbol:
- -
- Synonyms:
- RPB9, hRPB14.5
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-07
- Date modifiied:
- 2016-07-11
Related products to: POLR2I antibody
Related articles to: POLR2I antibody
- Congenital heart disease (CHD) is characterized by structural and functional anomalies of the heart and major blood vessels present at birth. It is recognized as the most common congenital defect. Epidemiological studies highlight the substantial contribution of genetic factors to CHD pathogenesis. In our previous study, RNA polymerase II subunit I (POLR2I protein) was identified as a candidate genetic contributor to CHD. However, its functional role remains largely unexplored. - Source: PubMed
Chen YukunZhang QiupingPeng XiaoyanWang XinruiCao HuaChen QiangHuang ShutingLei Yuqing - Despite genome-wide association studies having revealed risk loci for membranous nephropathy (MN), the functional mechanisms linking genetic variants to disease pathogenesis remain poorly understood. - Source: PubMed
Publication date: 2025/10/25
Chen QingsongWang GangZhao RuoHu QiyuanLi JiayunWang YutingRan JingyangHuang QiYu GuiquanLuo YanjiaLiao Xiaohui - Hypertensive nephropathy (HN), mainly caused by chronic hypertension, is one of the major causes of end-stage renal disease. However, the pathogenesis of HN remains unclarified, and there is an urgent need for improved treatments. Gene expression profiles for HN and normal tissue were obtained from the Gene Expression Omnibus database. A total of 229 differentially co-expressed genes were identified by weighted gene co-expression network analysis and differential gene expression analysis. These genes were used to construct protein-protein interaction networks to search for hub genes. Following validation in an independent external dataset and in a clinical database, , one of the hub genes, was identified as a key gene related to the pathogenesis of HN. The expression level of is upregulated in HN, and the up-regulation of is positively correlated with renal function in HN. Finally, we verified the protein levels of to confirm the accuracy of our analysis. In conclusion, our study identified as a key gene related to the pathogenesis of HN, providing new insights into the molecular mechanisms underlying HN. - Source: PubMed
Publication date: 2021/08/05
You ShilongXu JiaqiWu BoquanWu ShaojunZhang YingSun YingxianZhang Naijin - PM exposure is strongly linked to cardiac disease. Subtle epigenetic or transcriptional alterations induced by PM might contribute to pathogenesis and disease susceptibility of cardiac disease. It is still a major challenge to identify biological targets in human genetics. Human cardiomyocytes AC16 was chosen as cell model. Epigenetic effect of PM in AC16 was analyzed using Illumina HumanMethylation 450 K BeadChip. Meanwhile the transcriptomic profiling was performed by Affymetrix microarray. PM induced genome wide variation of DNA methylation pattern, including differentially methylated CpGs in promoter region. Then gene ontology analysis demonstrated differentially methylated genes were significantly clustered in pathways in regulation of apoptotic process, cell death and metabolic pathways, or associated with ion binding and shuttling. Correlation of the methylome and transcriptome revealed a clear bias toward transcriptional suppression by hypermethylation or activation by hypomethylation. Identified 386 genes which exhibited both differential methylation and expression were functionally associated with pathways including cardiovascular system development, regulation of blood vessel size, vasculature development, p53 pathway, AC-modulating/inhibiting GPCRs pathway and cellular response to metal ion/inorganic substance. Disease ontology demonstrated their prominent role in cardiac diseases and identified 14 cardiac-specific genes (ANK2, AQP1 et al.). PPI network analysis revealed 6 novel genes (POLR2I, LEP, BRIX1, ADCY6, INSL3, RARS). Those genes were then verified by qRT-PCR. Thus, in AC16, PM alters the methylome and transcriptome of genes might be relevant for PM-/heart-associated diseases. Result gives additional insight in PM relative cardiac diseases/associated genes and the potential mechanisms that contribute to PM related cardiac disease. - Source: PubMed
Publication date: 2018/09/03
Yang XiaozheFeng LinZhang YannanShi YanfengLiang ShuangZhao TongSun BaiyangDuan JunchaoSun Zhiwei - Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation. - Source: PubMed
Publication date: 2016/09/22
Long Nguyen PhuocLee Wun JunHuy Nguyen TruongLee Seul JiPark Jeong HillKwon Sung Won