Ask about this productRelated genes to: CRSP9 antibody
- Gene:
- MED7 NIH gene
- Name:
- mediator complex subunit 7
- Previous symbol:
- CRSP9
- Synonyms:
- CRSP33
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-21
- Date modifiied:
- 2014-11-19
Related products to: CRSP9 antibody
Related articles to: CRSP9 antibody
- Postoperative atrial fibrillation (POAF) is a common complication that can affect up to 20-44% of patients undergoing cardiac surgery. Evidence suggests that atrial fibrosis is a key factor in the development of POAF due to the disruption of the myocardial electric properties. This systematic review examines the correlation between pre-existing atrial fibrosis and the development of POAF after cardiac surgery. A systematic literature search was conducted in MEDLINE, Embase, and Google Scholar (2000 to March 2025) to identify studies that conducted comparative analysis of atrial fibrosis levels between those who did and did not develop POAF, using histological assessment methods. Extracted data, included study characteristics, histopathological staining methods and analysis findings, fibrosis quantification methods, and overall POAF incidence. Thirteen studies met the inclusion criteria, resulting in a total of 1222 patients, primarily undergoing coronary artery bypass surgery. The incidence of POAF ranged from 14%-42.4% (median 31.6%). In more than half of the studies (7/13), patients who developed POAF demonstrated statistically significant higher degrees of atrial fibrosis compared to those that remained in sinus rhythm postoperatively (four exhibited p < 0.001). Of the eight studies that conducted multivariate analyses, three identified atrial fibrosis as an independent POAF predictor. High heterogeneity precluded pooling of results into a meta-analysis. The current evidence examining the link between pre-existing atrial fibrosis and the development of POAF is restricted by methodological heterogeneity and inconsistent findings. Further efforts to standardize fibrosis quantification methods and POAF definitions are warranted before histopathological assessments can reliably inform POAF risk before cardiac surgery. - Source: PubMed
Publication date: 2026/04/19
Nawaz AbdulSohpal AmrinpreetMitra RishitAbu-Omar YasirElsebaie AbdelrahmanEl-Diasty Mohammad - Silver pomfret is an important economic fish, and the difference in growth rate is closely related to muscle development. The mechanism of muscle development in fast-growing and slow-growing groups was analysed by skeletal muscle morphology, texture characteristics and gene co-expression network. The results showed that hypertrophy was dominant in the fast-growing group (contribution rate 92.18%), and the muscle fibre diameter and area increased by 3.39 times and 19.94 times, respectively, compared to slow-growing group, whereas hyperplasia was dominant in the slow-growing group (contribution rate 82.11%). The muscle texture properties (elasticity 1.12 ± 0.04, hardness 377.5 ± 2.77, cohesion 0.78 ± 0.01) of the fast-growing group were significantly better than those of the slow-growing group (r = 0.05). Based on Weighted Gene Co-Expression Network Analysis (WGCNA), a total of eight modules were identified to be significantly correlated with growth phenotypes. Among them, the green module (muscle of fast-growing group, R = 0.99) enriched key genes taf1 and med7 and regulated autophagy, p53 signalling pathway and fatty acid metabolism. The key genes of the blue-green module (muscle of slow-growing group, R = 0.89), such as utp6, are involved in MAPK, mTOR pathway and cell cycle regulation. In liver tissues, the pink module (fast-growing muscle liver, R = 0.92) gene was associated with Polycomb inhibition complex, whereas the yellow module (slow-growing muscle liver, R = 0.94) gene was enriched in immune and glucose metabolism pathways. The results showed that the fast-growing group achieved efficient growth through muscle fibre hypertrophy and metabolism-signalling pathway synergism, whereas the slow-growing group relied on hypertrophic and conserved cellular regulatory mechanisms. - Source: PubMed
Publication date: 2025/12/01
Li ChangQin ChunlaiChen XinglongHuang XiangXu ShangliangYan XiaojunHu JiabaoWang Yajun - Minimally invasive cardiac surgery (MICS) has become a popular approach due to its potential benefits, such as improved cosmesis, faster recovery, shorter hospital stays, and cost-effectiveness, compared with traditional median sternotomy. However, there have been some concerns regarding procedural efficiency and surgical outcomes, especially in the early phase of the learning curve of these procedures. - Source: PubMed
Publication date: 2025/08/29
Elsebaie AbdelrahmanBoutros Christina SAwad Ahmed KSanad MohammedPelletier MarcAbu-Omar YasirEl-Diasty Mohammad - MED7, a middle-module subunit of the transcriptional co-regulator Mediator complex, plays a critical role in gene regulation in , where it is encoded by two paralogs, and . We present phenotypic analyses of homozygous MED7-silenced transgenic lines with significantly reduced expression of both paralogs under autotrophic conditions. Our findings demonstrate that MED7 is essential for proper cotyledon opening during de-etiolation, as the silenced lines showed a marked delay in this process. Additionally, these lines displayed distinct morphological alterations, including hyponastic cotyledons, elongated hypocotyls, and modified root architecture, such as shorter primary roots and impaired root hair development in light-grown seedlings. silencing also significantly hindered light-induced adventitious root (AR) formation on the hypocotyls of etiolated seedlings, leading to a notable reduction in AR production. Moreover, silencing impacted the timing of floral transition and shoot branching, resulting in delayed flowering and an increased number of primary cauline branches on the inflorescence stem. Together, these results underscore a central role for MED7 in orchestrating key developmental processes in plants. - Source: PubMed
Publication date: 2025/03/07
Kumar Koppolu Raja RajeshBlomberg JeanetteBjörklund Stefan - Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with poor prognosis. Baicalein, a natural compound, can regulate multiple cellular processes in various cancer types. In this study, we investigated the role of baicalein in regulating HCC and explored its potential mechanism. The expression of mediator complex subunit 7 (MED7) and E2F transcription factor 1 (E2F1) was analyzed by quantitative real-time polymerase chain reaction or Western blotting assay. Cell proliferation was assessed by cell colony formation assay and 5-ethynyl-2'-deoxyuridine assay. Cell migration was analyzed by transwell assay and wound-healing assay. Cell invasion was analyzed by transwell assay. Angiogenic ability of HCC cells was assessed by tube formation assay. Dual-luciferase reporter assay and chromatin immunoprecipitation assay were performed to validate the association between E2F1 and MED7. The xenograft mouse model assay was conducted to determine the effects of baicalein and E2F1 overexpression on tumor formation. Immunohistochemistry assay was used to determine positive expression rates of proteins. Upregulation of MED7 and E2F1 expression was observed in both HCC tissues and cells. Knockdown of MED7 suppressed HCC cell proliferation, migration, invasion, and tube formation. Transcriptional activation of MED7 by E2F1 was demonstrated in HCC cells. Overexpression of MED7 mitigated the effects induced by E2F1 depletion in HCC cells. Additionally, baicalein treatment effectively inhibited the tumor property of HCC cells by decreasing E2F1 expression in both in vitro and in vivo models. Baicalein inhibited the tumor property of HCC cells through the inactivation of the E2F1/MED7 axis, highlighting its potential clinical application in the treatment of HCC. - Source: PubMed
Song PinghuiShen NaiyingWu ZhongkunHe Sha