Ask about this productRelated genes to: OVOL1 antibody
- Gene:
- OVOL1 NIH gene
- Name:
- ovo like transcriptional repressor 1
- Previous symbol:
- -
- Synonyms:
- HOVO1
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-11
- Date modifiied:
- 2016-10-05
Related products to: OVOL1 antibody
Related articles to: OVOL1 antibody
- Eosinophilic esophagitis (EoE) is a type 2 allergic disease characterized by esophageal inflammation and epithelial cell dysfunction. The acquired loss of the anti-serine protease of kazal type 7 (SPINK7) in the squamous epithelium of the esophagus has a causal role in EoE pathogenesis. Yet there is a limited understanding of the factors that regulate its expression and responsiveness to inflammatory stimuli. Herein, we have identified the transcription factor, ovo like transcriptional repressor 1 (OVOL1) as an esophageal selective gene product that regulates SPINK7 promoter activity. Overexpression of OVOL1 increased SPINK7 expression, whereas its depletion decreased SPINK7 expression, impaired epithelial barrier and increased production of the pro-atopy cytokine thymic stromal lymphopoietin (TSLP). Stimulation with IL-13 abrogated the nuclear translocation of OVOL1 and promoted enhanced degradation of OVOL1 protein. This effect of IL-13 was dependent on the esophageal specific cysteine protease calpain-14 at least in part. Analysis of human esophageal biopsies demonstrated that the expression of esophageal OVOL1 correlated with SPINK7 transcript expression and was lost as a function of EoE disease activity. In summary, our study identifies key regulatory mechanisms in EoE pathogenesis, demonstrating that OVOL1 promotes SPINK7 transcription, whereas IL-13 suppresses this pathway in EoE. - Source: PubMed
Publication date: 2026/04/28
Azouz Nurit PKlingler Andrea MBeach Sierra SRossey Kalen ARochman MarkPaul MisuCaldwell Julie MBrusilovsky MichaelDwyer Alexander TChen XiaotingMiller DanielForney CarmyKottyan Leah CWeirauch Matthew TRothenberg Marc E - Building on the identification of ABCB5 as a marker of limbal stem cells (LSCs), this study examines CD63, a newly identified molecule co-expressed with ABCB5 in limbal epithelial cells, to define its role in maintaining corneal epithelial cell identity. - Source: PubMed
Sasamoto YuzuruSuzuki KoseiSato ShinriLee Catherine A AMartin GabrielleKsander Bruce RFrank Markus HFrank Natasha Y - The fruit of Gardenia jasminoides Ellis, which belongs to the plant family Rubiaceae, was first recorded in Shennong's Herbal Medicine and has been used in traditional Chinese medicine. Pharmacological studies have shown that Gardenia has certain liver- and gallbladder-protecting, blood sugar-lowering, pancreatic secretion-promoting, gastric function-protective, blood pressure-lowering, lipid-regulating, neuroprotective, anti-inflammatory, antioxidant, anti-fatigue, and anti-thrombotic activities. Moreover, G. jasminoides fruit extract (GJFE) can ameliorate symptoms of atopic dermatitis, but the specific mechanisms involved remain unclear. - Source: PubMed
Publication date: 2026/01/02
Xu PengWan YaoyingJin XiaoliYuan YongleiMa HongyuWang YichunWang FeifeiQu Liping - Ulcerative colitis (UC) is a complex chronic inflammatory disease. Centrosome amplification (CA) has been implicated in UC pathogenesis, but its mechanistic role remains unclear. This study aimed to investigate the relevance of centrosome amplification-related genes (CARGs) in UC progression. - Source: PubMed
Publication date: 2025/12/12
Yang ZhenhuanWu XingxingLuo LeiWu XiuxiaWang YuliangHuang TingtingDang ZhongqinNie Shanwen - Introduction Pleomorphic adenoma (PA) is the most common benign tumor of the salivary glands and has the potential for malignant transformation into carcinoma ex pleomorphic adenoma (CXPA). Ovo-like transcriptional repressor 1 (OVOL1) is a transcription factor that regulates epithelial differentiation by suppressing epithelial-mesenchymal transition (EMT) and promoting mesenchymal-epithelial transition (MET). OVOL1 expression is regulated by the Wnt signaling pathway, a central regulator of epithelial stem cell development, maintenance, and differentiation. While several transcription factors are implicated in EMT/MET, OVOL1 is of particular interest because of its potential dual role in maintaining epithelial identity and modulating tumor behavior. Its dysregulation has been associated with adverse prognosis in several cancers. Therefore, this study aims to investigate OVOL1 expression in PA and CXPA to clarify its potential role in the transition from benign to malignant lesions and to improve the assessment of tumor biological behavior. Materials and methods This retrospective comparative cohort study included 40 cases, 20 cases of PA and 20 cases of CXPA, diagnosed between 2017 and 2024, retrieved from the archive of the Pathology Laboratory at Mansoura University's Oncology Center. Owing to the rarity of CXPA, all eligible cases during the study period were included. To provide a balanced comparator group and minimize selection bias, an equal number of PA cases were consecutively selected from the same archive and timeframe. Clinical data were obtained from electronic medical records. Hematoxylin and eosin-stained slides were reviewed by expert pathologists to confirm the diagnosis. Morphological subtyping of CXPA was performed according to the most recent WHO Classification of head and neck tumors. OVOL1 immunohistochemical expression was evaluated in both PA and CXPA using a combined semi-quantitative immunoreactive score (IRS) and quantitative digital image analysis (ImageJ software), ensuring greater objectivity and reproducibility. Correlations with clinicopathological features were examined using appropriate statistical tests. Results All studied PA and CXPA cases were OVOL1-positive with different levels of expression. PA cases predominantly showed high expression, while most CXPA demonstrated low levels, with a significant difference between the two groups. Low OVOL1 expression was more frequent in high-grade and recurrent CXPA, suggesting a link with tumor aggressiveness. Conclusion Our results suggest the potential of OVOL1 as a diagnostic and prognostic biomarker, particularly in distinguishing PA from CXPA, and as a promising indicator of tumor aggressiveness and malignant transformation. While these findings are limited by the small cohort size, they provide preliminary evidence that warrants validation in larger, multi-institutional studies exploring their clinical significance and underlying molecular mechanisms. - Source: PubMed
Publication date: 2025/10/11
Mohamed AashaAbbas El-Sissy NadiaAbdelrahim El Kashty OsamaM Zaki Marwa