Ask about this productRelated genes to: CCNH antibody
- Gene:
- CCNH NIH gene
- Name:
- cyclin H
- Previous symbol:
- -
- Synonyms:
- p34, p37, CycH
- Chromosome:
- 5q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-16
- Date modifiied:
- 2016-10-05
Related products to: CCNH antibody
Related articles to: CCNH antibody
- Sterilization is a prerequisite for the clinical use of medical devices. Gamma irradiation is a high-penetrating, low-temperature process used in biomaterials. However, it can alter materials' properties, potentially changing their functional performance. In this study, three dimensional (3D)-printed chitosan-bioactive glass scaffolds were processed with clinically relevant gamma irradiation doses (15 and 25 kGy) and evaluated for nerve tissue engineering. Physicochemical characterizations were performed using FTIR, DSC, SEM, mechanical testing, swelling, and degradation assays. Biological performance was assessed with relevant cell lines using indirect cytotoxicity assays, complemented by adhesion and morphological analyses. FTIR and DSC analyses suggested changes consistent with simultaneous irradiation-induced structure rearrangement and enhanced intermolecular interactions. These events enhanced mechanical properties, reduced fluid uptake, and slowed scaffold degradation. Furthermore, high cell viability and adhesion showed that cytocompatibility was preserved. Overall, gamma radiation can be used not only for sterilization but also to improve the scaffold's structural and mechanical integrity, supporting its potential for nerve tissue engineering applications. - Source: PubMed
Lourenço LarissaSantos Erik F DosAlberto-Silva CarlosBorges RogerMathor Monica BMarchi Juliana - In miRNA-mRNA regulatory modules of Setaria italica, the candidate novel miRNAs Sit-miR74-N/APX7 and Sit-miR132-N/PEPC involved in key pathways underlying water-deficit response have been detected. In the first module, APX7 expression was directly associated with water-deficit intensity, whereas in the second module, PEPC activation occurred under moderate water deficit. Drought severely constrains plant growth and productivity, yet the underlying regulatory mechanisms remain incompletely understood. Here, we determined the miRNA-mediated post-transcriptional landscape during water deficit in the panicoid grass Setaria italica. Two independent water-deficit experiments combined with small RNA and degradome sequencing identified 159 miRNAs, including 135 candidate novel sequences, of which 20 were differentially expressed under contrasting watering regimes. In silico analysis predicted 1,612 miRNA-mRNA regulatory modules, representing a broad landscape of potential post-transcriptional regulation. Complementarily, degradome sequencing identified 19 miRNA-mRNA modules, several of which exhibited inverse expression patterns, particularly under severe water-deficit conditions. Functional annotation of target mRNAs uncovered multiple functional processes, including transcriptional regulation, photosynthesis, redox homeostasis, and solute transport. Additionally, transient expression assays validated selected miRNA-mRNA modules, confirming the interaction between candidate novel miRNAs and water deficit-related mRNA targets. These modules are involved in key water deficit-responsive pathways, including oxidative stress regulation (Sit-miR74-N/APX7), photosynthetic carbon metabolism (Sit-miR132-N/PEPC), and flavonoid biosynthetic pathways (Sit-miR39-N/OMT). Together, these findings reveal a complex regulatory network in which miRNAs contribute to the coordination of water-deficit responses in S. italica, with post-transcriptional regulation underlying plant responses to abiotic stress. - Source: PubMed
Publication date: 2026/08/10
Rodrigues Juliana MTheodoro Vitor G BCarvalho Gabriel GCesarino Igorde Oliveira Leandro Fde Setta Nathalia - We investigate the thermodynamic, structural, and dynamic behavior of a three-dimensional coarse-grained ramp-shoulder fluid derived from effective interactions between polymer-grafted nanoparticles. The interaction combines a softened repulsive ramp with a shallow attractive shoulder, stabilizing competing local organizations over a broad pressure interval. Molecular dynamics simulations reveal density, diffusion, and structural anomalies together with crystalline, amorphous, and fluid regions in the phase diagram. Unlike conventional isotropic core-softened fluids, the anomalous hierarchy becomes partially decoupled: the density anomaly extends beyond the structural anomaly, while the diffusion anomaly becomes closely connected to amorphization and shell migration processes. Analysis of radial distribution functions, excess entropy, translational and orientational order, and coordination-shell organization shows that the anomalies are not controlled solely by shell competition. Instead, they emerge from cooperative radial restructuring in a regime where radial correlations increase without the development of crystalline orientational order. The results indicate that the detailed shape of the softened interaction region strongly influences the structural pathways explored under compression, leading to a regime of amorphous radial frustration associated with anomalous diffusion and frustrated shell reorganization. - Source: PubMed
Marques Murilo SodréRamalho Santana Lucas AxelSan Rodrigues Ribeiro Câmara GabrielBordin José Rafael - With the increase in the complexity of materials used in various sophisticated electronic devices, recycling of e-waste is increasingly challenging. In the present study, we have converted thermoelectric (TE) waste into a functional hydrogen evolution reaction (HER) electrocatalyst by considering a circular-economy and low-carbon approach. The as-received TE waste was processed through ball milling (TE waste-BM) and melting-casting (TE waste-M) routes. Morphological and structural evaluations revealed that the formation of a BiSbTe/ZnTe heterostructure in TE-waste-M promotes HE efficiency when compared to the presence of a BiTe/BiSbTe heterostructure (TE-waste-BM). TE waste-M exhibited lower overpotential and a smaller Tafel slope than TE waste-BM and stable operation for 18 h with negligible current decay, attributed to the accelerated charge transfer, fast water dissociation steps and rapid hydrogen adsorption in TE waste-M, originating from the presence of a BiSbTe/ZnTe heterostructure and defect-enriched interfaces. First-principles calculations based on density functional theory (DFT) revealed that the strengthened bonding states of the heterostructures near the Fermi level aid in enhancing the HER activity of the BiSbTe/ZnTe heterostructure. This work simultaneously integrates waste management with green hydrogen production by offering an economically viable, scalable and low-carbon approach to HER catalysts. - Source: PubMed
Publication date: 2026/08/19
Usa Gemeda JemalOliveira Caique CPal VarinderSarkar SumanFeyisa Gebisa BekeleKotal MoumitaOlu Emmanuel FemiAutreto Pedro A SDesissa Temesgen DebeloTiwary Chandra Sekhar - Superparamagnetic iron oxide nanoparticles (SPIONs-FeO) functionalized with l-cysteine (SPIONs-l-Cys) were evaluated as a biocompatible, magnetically responsive nanosystem in an Ehrlich solid tumor model. The formulation was obtained by chemical coprecipitation, and its complementary physicochemical characterization is provided in the Supporting Information and supported by our previous report on the same l-cysteine-functionalized magnetite system, including X-ray diffraction, FTIR, hydrodynamic size, polydispersity index, ζ-potential, surface thiol quantification by DTNB, magnetic measurements, and complementary in vitro data. The supplementary characterization supports the preservation of the magnetite crystalline structure after functionalization and confirms the presence of free thiol groups in an aqueous dispersion. cytotoxicity assays using human mononuclear cells and Ehrlich tumor cells indicated low toxicity under selected experimental conditions and biologically relevant redox-associated activities. evaluation demonstrated preserved hematological and biochemical parameters, the absence of overt systemic toxicity, and reduced tumor burden in groups treated with SPIONs-l-Cys under magnetic targeting conditions. These findings support the biological compatibility of SPIONs-l-Cys and indicate antitumor-associated effects under localized magnetic field conditions, while not establishing intratumoral accumulation, drug delivery, or a definitive mechanism of action. - Source: PubMed
Publication date: 2026/07/17
da Silva Emerson BarbosaBritos Tatiane NassarChagas Camila Dos SantosPetri Giulianada Veiga Glaucia Raquel LucianoReis Beatriz da Costa Aguiar AlvesHaddad Paula SilviaFerreira Fabio FurlanFonseca Fernando Luiz Affonso