Ask about this productRelated genes to: FTSJ2 antibody
- Gene:
- MRM2 NIH gene
- Name:
- mitochondrial rRNA methyltransferase 2
- Previous symbol:
- FTSJ2
- Synonyms:
- FJH1, RRMJ2
- Chromosome:
- 7p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-09
- Date modifiied:
- 2016-10-05
Related products to: FTSJ2 antibody
Related articles to: FTSJ2 antibody
- Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely associated with mitochondrial dysfunction, but the underlying mechanism remains unclear. - Source: PubMed
Publication date: 2026/07/28
Zhang ZhongweiLiu JunXue WeiZhang HaoranWang MimiLiu Qing-Jie - Blood cells are affected in nearly all ionizing radiation exposure scenarios. Whole transcriptome data offer detailed insights into blood's radiation response, crucial for radiotherapy and biodosimetry. We conducted genome-wide RNA-seq analysis on blood from three donors irradiated ex vivo with X-rays and incubated for 2 h and 6 h. Gene expression was subject to strong inter-donor variation and time post-exposure. After 0.5, 1, 2, and 4 Gy X-rays, 5, 33, 84, and 364 genes (2 h) and 72, 99, 274, and 607 genes (6 h) were differentially expressed (DEG), compared to 0 Gy. The corresponding number of the inferred transcription factors was 255, 253, 274, and 292 after 2 h and 214, 245, 262, and 279 after 6 h. In sham-irradiated blood, 924 DEGs and 165 transcription factors were affected by ex vivo incubation alone. We identified 34 radioresponsive DEGs not previously described, 8 and 9 showing significant positive or negative correlations with dose, respectively, including GPN1, MRM2, G0S2, and PTPRS. DNA damage signaling pathways were affected from the lowest dose, with doses ≥ 2 Gy additionally triggering proinflammatory responses. This genome-wide RNA-seq study of ex vivo X-ray-exposed human blood reveals novel radiosensitive genes, transcription factors, and pathways, enhancing the understanding of the consequences of diagnostic, therapeutic, or accidental exposures on the highly radioresponsive blood system. - Source: PubMed
Publication date: 2025/06/05
Salah AhmedWollschläger DanielCallari MaurizioSchmidberger HeinzMarini FedericoZahnreich Sebastian - This work reports a characterization of microplastics (MPs) and microrubbers (MRs) such as color, size, shape, and the chemical composition in snowfall in central Iran (Qom) at five sites. Identification of MPs and MRs involved using a stereo microscope to evaluate physical characteristics such as thickness, shininess, hardness, and reaction to a hot needle. HYSPLIT trajectory and end-member microplastic (PM) mixing models are used to determine the contribution of local and remote sources to MPs. The mean (±SD) abundance of MPs and MRs is 23.8 ± 15.87 (MP/L) and 1.26 ± 1.16 (MR/L), respectively, whereas the mean (±SD) abundance of MPs and MRs is 30.7 ± 19.36 (MP/m) and 1.58 ± 1.39 (MR/m), respectively. The frequency of MP colors in order are: black (63.8%) > red (12.8%) > blue (11 %) > white (9.1%) > green (2.1%) > yellow (1.3%). About 71.6% and 3.6% of the identified MPs are 250-500 μm and >1000 μm, respectively. Snow samples contain different identified polymers such as polyethylene terephthalate (PET), nylon, viscose, polypropylene (PP), polyethylene (PE), polystyrene (PS), and polyvinyl chloride (PVC). Analysis reveals that 90% of Qom city's snowy day winds come from local sources. The high MP levels in are due to human activities from local origins according to end-member MP mixing model. Further study is needed to understand the potential impacts of MPs and MRs on ecosystems and human health. - Source: PubMed
Publication date: 2024/10/11
Ranjdoost FatemehAbbasi SajjadAsadi-Ghalhari MahdiBaghani Abbas NorouzianFouladi-Fard RezaSorooshian ArminGhaffari Mohmmad-Ebrahim - Ribosomes are large macromolecular complexes composed of both proteins and RNA, that require a plethora of factors and post-transcriptional modifications for their biogenesis. In human mitochondria, the ribosomal RNA is post-transcriptionally modified at ten sites. The N4-methylcytidine (mC) methyltransferase, METTL15, modifies the 12S rRNA of the small subunit at position C1486. The enzyme is essential for mitochondrial protein synthesis and assembly of the mitoribosome small subunit, as shown here and by previous studies. Here, we demonstrate that the mC modification is not required for small subunit biogenesis, indicating that the chaperone-like activity of the METTL15 protein itself is an essential component for mitoribosome biogenesis. - Source: PubMed
Publication date: 2024/06/24
Mutti Christian DVan Haute LindseyMinczuk Michal - In recent years, the phenomenon of the production and trade of synthetic cannabinoids has grown, becoming a public health issue worldwide. The recent access- to the ED of the hospital of Trieste- of people who complained of episodes of hallucinations, sensation of poisoning, tachycardia, and air hunger following the inhalation of "Che Sballo platinum", have highlighted the need to perform further analysis on the contents of the packet sold as an air freshener, produced in Koper (Slovenia). - Source: PubMed
Peruch MichelaAddobbati RiccardoPadovano MartinaScopetti MatteoConcato MonicaRadaelli DavideD'Errico Stefano