Ask about this productRelated genes to: GTF2E2 antibody
- Gene:
- GTF2E2 NIH gene
- Name:
- general transcription factor IIE subunit 2
- Previous symbol:
- -
- Synonyms:
- TFIIE-B, FE, TF2E2
- Chromosome:
- 8p12
- Locus Type:
- gene with protein product
- Date approved:
- 1993-08-16
- Date modifiied:
- 2018-03-06
Related products to: GTF2E2 antibody
Related articles to: GTF2E2 antibody
- Accumulating evidence suggests reciprocal risk factors between periodontitis (PD) and systemic sclerosis (SSc). Ferroptosis, an iron-dependent and immune-related form of cell death, has been implicated in both diseases, yet its shared molecular mechanisms remain largely unclear. - Source: PubMed
Publication date: 2026/04/02
Zhang ShengchaoYang ShengweiGe CuiJi ChaoLin RuohanXue WenjuanLiu DongxiuChen Fulin - Transcription initiation factor IIE subunit beta (GTF2E2) is a crucial component of the RNA polymerase II transcription initiation complex. There is a lack of more detailed research on the biological function of GTF2E2 in pan-cancer. - Source: PubMed
Publication date: 2025/04/23
Zhang NieQin XuejinLiu JingjingHan KeKang ManmanZhu ZhengchunZhang DiZhong Fei - Rare coding alleles play crucial roles in the molecular diagnosis of genetic diseases. However, the systemic identification of these alleles has been challenging due to their scarcity in the general population. Here, we discovered and characterized rare coding alleles contributing to genetic dyslipidemia, a principal risk for coronary artery disease, among over a million individuals combining three large contemporary genetic datasets (the Million Veteran Program, n = 634,535, UK Biobank, n = 431,178, and the All of Us Research Program, n = 92,304) totaling 1,158,017 multi-ancestral individuals. Unlike previous rare variant studies in lipids, this study included 238,243 individuals (20.6%) from non-European-like populations. Testing 2,997,401 rare coding variants from diverse backgrounds, we identified 800 exome-wide significant associations across 209 genes including 176 predicted loss of function and 624 missense variants. Among these exome-wide associations, 130 associations were driven by non-European-like populations. Associated alleles are highly enriched in functional variant classes, showed significant additive and recessive associations, exhibited similar effects across populations, and resolved pathogenicity for variants enriched in African or South-Asian populations. Furthermore, we identified 5 lipid-related genes associated with coronary artery disease . Among them, is a potentially novel therapeutic target through the down regulation of LDLC by its silencing. This study provides resources and insights for understanding causal mechanisms, quantifying the expressivity of rare coding alleles, and identifying novel drug targets across diverse populations. - Source: PubMed
Publication date: 2024/09/18
Koyama SatoshiYu ZhiChoi Seung HoanJurgens Sean JSelvaraj Margaret SunithaKlarin DerekHuffman Jennifer EClarke Shoa LTrinh Michael NRavi AkshayaDron Jacqueline SSpinks CatherineSurakka IdaBhatnagar AarushiLannery KimHornsby WhitneyDamrauer Scott MChang Kyong-MiLynch Julie AAssimes Themistocles LTsao Philip SRader Daniel JCho KellyPeloso Gina MEllinor Patrick TSun Yan VWilson Peter WfProgram Million VeteranNatarajan Pradeep - Glioblastoma is the most common malignant tumor in the central nervous system. The general transcription factor IIE subunit beta (GTF2E2) is crucial for physiological and pathological functions, but its roles in the malignant biological function of glioma remain ambiguous. CCK-8, colony formation assays, TUNEL assays, cell migration assays, wound-healing assays, and xenograft model were established to investigate the biological functions of GTF2E2 both in vitro and in vivo. GTF2E2 was overexpressed in glioma and was associated with poor prognosis of glioma patients. Biological functions of GTF2E2 were investigated both in vitro and in vi0vo by multiple experiments. Moreover, we explored the possible mechanisms of GTF2E2. In our results, we demonstrated that GTF2E2 could be regulated by miR-340-5p directly or indirectly. CCND1 was transcriptionally affected by GTF2E2 and glioma progression was then regulated. Our data presented the overexpression of GTF2E2 in glioma and indicated the association between GTF2E2 and glioma prognosis. GTF2E2 was found to be regulated by miR-340-5p and thus affect downstream gene expressions and glioma progression. Our results indicate that GTF2E2 might be a potential target in the diagnosis and treatments of glioblastoma. - Source: PubMed
Publication date: 2023/10/16
Qiao XiaolongChen YinanWang ZixuanPeng NanNiu WanxiangHou ShiqiangWu JiayingJi YingNiu ChaoshiCheng Chuandong - - Source: PubMed
Publication date: 2023/10/16
Sperelakis-Beedham BrianRuaud LyseVial YoannRachid MyriamAgeorges FaustineGoujon LouiseVerloes AlainTabet Anne-ClaudeBourrat EmmanuelleLÊvy Jonathan