Ask about this productRelated genes to: NARG1 antibody
- Gene:
- NAA15 NIH gene
- Name:
- N(alpha)-acetyltransferase 15, NatA auxiliary subunit
- Previous symbol:
- NARG1
- Synonyms:
- TBDN100, NATH, FLJ13340
- Chromosome:
- 4q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-01
- Date modifiied:
- 2015-04-24
- Gene:
- NAA16 NIH gene
- Name:
- N(alpha)-acetyltransferase 16, NatA auxiliary subunit
- Previous symbol:
- NARG1L
- Synonyms:
- FLJ22054, MGC40612, PRO2435
- Chromosome:
- 13q14.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-01
- Date modifiied:
- 2015-04-24
Related products to: NARG1 antibody
Related articles to: NARG1 antibody
- N-terminal acetylation, catalyzed by N-terminal acetyltransferase (NAT) complexes, is one of the most prevalent protein modifications in eukaryotic cells, yet its role in heart development remains poorly understood. Here, we use as an in vivo platform to investigate the functions of NAT complex components in cardiac development and congenital heart disease (CHD). Focusing on the NatA complex, we showed that cardiac-specific knockdown of each of its three subunits (, , and ) led to developmental lethality, structural disorganization, fibrosis, and impaired cardiac function in . Remarkably, human NAA16 completely rescued the cardiac defects in silenced , whereas a CHD-associated variant (NAA16-R70C) failed to do so, providing direct functional evidence of its pathogenicity. Together, these findings suggest the NatA complex as a critical regulator of heart development and provide functional validation linking variants in NatA complex genes to CHD. Further studies in mammalian models will be required to provide additional supporting evidence. - Source: PubMed
Publication date: 2025/10/14
Zhu Jun-YiSeah HannahLee HangnohLiu HanhanHan Zhe