Ask about this productRelated genes to: ARID4A antibody
- Gene:
- ARID4A NIH gene
- Name:
- AT-rich interaction domain 4A
- Previous symbol:
- RBBP1
- Synonyms:
- RBP1, RBP-1
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-17
- Date modifiied:
- 2016-10-05
Related products to: ARID4A antibody
Related articles to: ARID4A antibody
- Neurotrophic tyrosine receptor kinase (NTRK) gene fusions, although present in fewer than 2 % of gliomas, are recognized oncogenic drivers. With the approval of NTRK-targeted therapies, increasing attention has focused on these tumors, as targeted treatments may substantially enhance outcomes. This study aimed to characterize the pathological features and molecular diversity of pediatric NTRK-rearranged gliomas to inform targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/02/09
Zhao JingTian FengDing DiFeng JiayanShi WeiLiu JiaqiTian YongliMa Yangyang - HOXB5, a member of the homeobox (HOX) gene family. Its dysregulated expression has been increasingly reported across multiple human cancers, where it correlates with malignant progression and poor clinical outcomes. A concise synthesis of its regulatory networks and cancer-associated functions is therefore needed to clarify its biological and translational significance. - Source: PubMed
Publication date: 2026/01/06
Zhong KuiYi QiangChen ZhengXu YongchangZeng YangnengZhong Jinghua - The nucleosome, as the fundamental unit of chromatin, interacts with a diverse range of proteins, crucially regulating gene expression. In this study, we introduce an AlphaFold-based algorithm designed to analyze nucleosome-binding proteins from a dataset of over 7600 human nuclear proteins. Using proteins that interact with the nucleosome acidic patch as a benchmark, our screening achieves a successful prediction rate of 77% (23 out of 30 proteins). This predictive approach has led to the identification of ARID4A and ARID4B as novel nucleosome-binding proteins. Additionally, this analytical method was used to study RING-family ubiquitin E3 ligase RNF168, demonstrating that RNF168 dimerization enhances its binding to the nucleosome, a finding confirmed by cryogenic-electron microscopy structural analysis. Our findings offer a rapid and effective method for the discovery and characterization of nucleosome-binding proteins and emphasize the significant role of ubiquitin E3 ligase dimerization in epigenetic regulation. - Source: PubMed
Yang XinZhu HaoqiangShi LiuxinSong TingruiGong WeibinHe ShunminShan ShanXu ChunfuZhou Zheng - The ban on the use of antibiotics as growth promoters due to resistance issues has urged scientists to find alternatives to antibiotics. In recent years, probiotics have gained widespread attention for their potential benefits on systemic physiological functions. However, little is known about how Pediococcus acidilactici supplementation specifically influences sperm quality, testicular development, and the molecular mechanisms underlying male reproductive performance in roosters. Therefore, this study aimed to evaluate the effects of different levels of Pediococcus acidilactici supplementation on the reproductive performance of roosters. Roosters were randomly assigned to four groups: a control group (fed a basal diet) and three treatment groups supplemented with Pediococcus acidilactici at P1 (1 × 10), P2 (1 × 10), and P3 (1 × 10) CFU/mL. Over a five-week trial period, semen parameters, motility, viability, mitochondrial membrane potential, apoptosis, protamine deficiency, reproductive hormone levels, testicular histological parameters, and transcriptomic profiles were assessed. The results demonstrated that the beneficial effects of Pediococcus acidilactici supplementation on rooster semen quality progressively increased with prolonged feeding duration. Notably, in the final week, compared with the control group, the P2 and P3 groups exhibited significantly improved sperm parameters (P < 0.01), motility (P < 0.05), viability, and mitochondrial function (P < 0.01), while apoptosis (P < 0.05) and protamine deficiency (P < 0.01) were significantly reduced. Additionally, reproductive hormone levels, testicular histology, and testicular antioxidant capacity were also significantly improved in the P2 and P3 groups (P < 0.05). Finally, transcriptomic analysis identified five key genes (RAF1, PIK3R1, ATRX, ARID4A, and SOX9) and four signaling pathways involved in testicular development. These findings suggest that supplementation with an appropriate level of Pediococcus acidilactici, particularly at 1 × 10 CFU/mL, probably can enhance the reproductive capacity of roosters by improving sperm quality and testicular development. - Source: PubMed
Publication date: 2025/06/21
Lv YanqiuWang YinanChen XuanXuan BiaoYu LongzhengLiang WanfengJin Yi - The Chinese tongue sole () is a commercially important mariculture species; however, its fertilization and hatching rates under artificial conditions remain relatively low. Zona pellucida proteins (ZPs), which mediate sperm-egg binding, were previously identified as differentially expressed genes between newly differentiated ovaries and testes in . In this study, we identified 25 ZPs of through genomic analysis and classified them into five subfamilies. All genes possessed a conserved ZP domain, characteristic of the gene family from mammals to teleosts. Among them, nine genes were highly expressed in ovary cells, with the expression levels increasing during ovarian development, while another three genes were predominantly expressed in liver cells. Protein-protein interaction analysis predicted that 12 ZPs interacted with key reproductive regulators such as Gdf9, Arid4a, Arid4b, and Rbl, which were involved in steroidogenesis, sperm-egg recognition, and folliculogenesis. Functional analyses using RNA interference revealed that knockdown in ovarian cells led to the downregulation of , , , and , while the expression of , , , and was upregulated. In contrast, knockdown resulted in decreased expression of , , , and , along with upregulation of , , and . These results suggested that ZP genes might contribute to ovarian homeostasis by regulating steroid hormone synthesis, follicular development, and ovulation. This study contributed to a deeper understanding of the reproductive mechanisms of and provided evolutionary insights into the functional divergence of the ZP gene family across teleosts. - Source: PubMed
Publication date: 2025/06/02
Zhang KailiChen ZhangfanGao ChengbinLi XihongWang NaZhang MinYan HaipengSha ZhenxiaChen Songlin