Ask about this productRelated genes to: NUP93 antibody
- Gene:
- NUP93 NIH gene
- Name:
- nucleoporin 93
- Previous symbol:
- -
- Synonyms:
- KIAA0095
- Chromosome:
- 16q13
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-19
- Date modifiied:
- 2018-10-09
Related products to: NUP93 antibody
Related articles to: NUP93 antibody
- Mature body size and weight of sheep are important traits that significantly influence mutton yield and economic benefits of sheep farming. The exploration for key genes underlying these traits will facilitate the advancement of molecular breeding in meat sheep. In this study, key candidate genes for five body size traits and the body weight were identified in mature Huameng meat sheep through GWAS and ROH analysis. After quality control, 451 individuals and 16 751 761 variants were analyzed using EMMAX software in a linear mixed model (LMM). A total of 3 genome-wide and 35 chromosome-wide significant SNPs were identified, respectively. Several key candidate genes have been uncovered, including ZFAT, ACSL3, and GRID2 for cannon bone circumference; UNC5C and BMPR1B for body weight and chest girth; PCDH15 and NUP93 for hip width; and PTPRD for body height. ROH analysis revealed a high-frequency ROH hotspot region on chrX. In addition, ROH analysis suggested that inbreeding may lead to a significant depression in body height of sheep. This study provides important clues for revealing the molecular mechanisms underlying sheep body morphological traits and identifies key candidate genes for molecular breeding in meat sheep. - Source: PubMed
Wang Y FGong Y MChen H SWang Y FChen Q JChen KSong Y ZMeng ZZhang G QLi HChu M XDi R - Strategies that specifically target the integrated stress response (ISR) as a therapeutic approach in sepsis remain largely unexplored. This study aimed to identify and validate ISR-related biomarkers in sepsis. - Source: PubMed
Publication date: 2026/03/19
Zhou YouWu YouZhu YuanJiang QinLiu YuZhu LishaZhu RuiCao Haiquan - Gemcitabine is a cornerstone chemotherapeutic for pancreatic ductal adenocarcinoma (PDAC); however, the frequent development of resistance compromises its efficacy and poses a significant challenge to patient prognosis. Here, we report that nuclear pore protein NUP93 is upregulated in PDAC and correlates with poor patient survival. Functional studies demonstrated that NUP93 promotes PDAC cell proliferation and confers gemcitabine resistance by enhancing DNA damage repair. Mechanistically, NUP93 interacts with the transcription factor SOX2 by recognizing its nuclear localization sequence and facilitates its nuclear import. Nuclear SOX2 transcriptionally activates the key stress granule component G3BP1 by directly binding to its promoter. Subsequently, G3BP1 stabilizes the mRNA of RAD51, a crucial homologous recombination repair factor, thereby promoting DNA damage repair and gemcitabine resistance. In vivo, disruption of the NUP93/SOX2/G3BP1 axis suppressed tumor growth and synergized with gemcitabine. Our findings unveil the novel NUP93-SOX2-G3BP1 signaling axis as a critical driver of gemcitabine resistance in PDAC, presenting a promising therapeutic target for overcoming chemoresistance. - Source: PubMed
Publication date: 2026/03/28
Sun HaoYang ChenxiaoDu JuntongXu ChaoChen YaoChen JinsuoYue NanxiGong RuiningYang Zhan - Nuclear export of messenger RNAs (mRNAs) through nuclear pore complexes (NPCs) is a critical step in gene expression. Although N-adenosine methylation (mA) has been implicated in this process, the underlying mechanism remains obscure. Here we demonstrate, using single-molecule imaging, that mA markedly accelerates the nuclear export of messenger ribonucleoproteins (mRNPs) by increasing export efficiency and shortening export time through NPCs. We further show that the mA methyltransferase METTL3 localizes at NPCs and functionally associates with the nucleoporin NUP93 to promote the efficient export of mA-modified mRNPs. The disruption of this functional association between METTL3 and NUP93 substantially impairs overall mRNP export efficiency. Notably, a steroid-resistant nephrotic syndrome (SRNS)-associated NUP93 variant (c.1162C>T, p.Arg388Trp) fails to associate with METTL3, resulting in the defective nuclear export of key methylated mRNAs required for kidney function. Together, our findings define an mA-METTL3-NUP93 regulatory axis for nuclear mRNA export with broad implications for human disease. - Source: PubMed
Publication date: 2026/03/05
Lee Ji HoonTingey MarkZhang ZhaoBuerger FlorianHong JuyeongZhang GuanshiYang MeiDu BaowenJeong Ji-HoonJohn Kayode ATamayo Ian MZhao Qingwei DHildebrandt FriedhelmĐurišić MarinaStajić NatašaSpasojević BrankicaYang WeidongXu Kexin - Enhancer RNAs (eRNAs) have emerged as important regulators of gene expression and may reshape the therapeutic landscape of prostate cancer. However, their global landscape and clinical relevance in prostate cancer remain unclear. - Source: PubMed
Publication date: 2026/02/10
Yu ChenglingWen YongLi YanguoSong BaiyangHu YiweiMeng ZixingYan ZejunDu WeiRong Hao