Ask about this productRelated genes to: POLR2G antibody
- Gene:
- POLR2G NIH gene
- Name:
- RNA polymerase II subunit G
- Previous symbol:
- -
- Synonyms:
- hRPB19, hsRPB7, RPB7
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-07
- Date modifiied:
- 2016-10-05
Related products to: POLR2G antibody
Related articles to: POLR2G antibody
- Gestational diabetes mellitus (GDM), one of the prevalent pregnancy-related metabolic disorders, have shown immediate or long-term adverse health outcomes for maternal and fetal health. Therefore, it is crucial to understand the ongoing cellular and molecular changes in GDM patients for characterizing novel biomarkers for diagnosis and therapeutic purposes. In the current study, we analyzed 3 transcriptomic datasets, characterized 449 unique upregulated and 785 downregulated DEGs, and performed several analyses. Gene ontology shows enrichment of migration, development, and immune-related processes in GDM patients. KEGG pathway shows enrichment of pathways like "type 1 diabetes mellitus" and "graft versus host disease". Disease ontology shows enrichment of "female reproductive system disease," "anemia," etc. Integration of methylation and transcriptomic data identified 11 genes (RASSF2, WSCD1, TNFAIP3, TPST1, UBASH3B, ZFP36, CRISPLD2, IGFBP7, TNS3, TPM2, and VTRNA1-2), as potential novel diagnostic biomarkers and therapeutic targets. Furthermore, immune cell-type infiltration analysis shows higher memory B-cells and lower M1 macrophages and CD8 T-cells. Protein-protein interaction analysis followed by ROC analysis in an independent dataset identified 7 hub genes (POLR2G, VWF, COL5A1, COL6A1, CD44, COL3A1, and COL1A1) with high diagnostic potential. Overall, we obtained 18 genes that could serve as novel diagnostic biomarkers and therapeutic targets in GDM patients. - Source: PubMed
Publication date: 2025/09/25
Mitra TridipYadav Dinesh VenkatesanKumari R SajeethaAgrawal PiyushJanardhanan Rajiv - Sepsis, like neutropenic sepsis, is a medical condition in which our body overreacts to infectious agents. It is associated with damage to normal tissues and organs by the immune system, which leads to the spread of inflammation throughout our body. Of note, microRNAs (miRNAs) have been found to have a critical role in the sepsis progression. Such miRNAs are registered in the miRNA databases, such as Gene Expression Omnibus (GEO), with a specific identifier and unique characteristics. There is also computational software, such as TargetScan, that are broadly employed for the analysis of miRNAs, including their identification, target prediction, and functional analysis. - Source: PubMed
Musavi MaryamHaftcheshmeh Saeed MohammadianFazel HadiMomtazi-Borojeni Amir Abbas - Climate change poses a growing threat to the livestock industry, impacting animal productivity, animal welfare, and farm management practices. Thus, enhancing livestock climatic resilience (CR) is becoming a key priority in various breeding programs. CR can be defined as the ability of an animal to be minimally affected or rapidly return to euthermia under thermally stressful conditions. The primary study objectives were to perform genome-wide association studies for 12 CR indicators derived from variability in longitudinal vaginal temperature in lactating sows under heat stress conditions. A total of 31 single nucleotide polymorphisms (SNPs) located on nine chromosomes were considered as significantly associated with nine CR indicators based on different thresholds. Among them, only two SNPs were simultaneously identified for different CR indicators, SSC6:16,449,770 bp and SSC7:39,254,889 bp. These results highlighted the polygenic nature of CR indicators with small effects distributed across different chromosomes. Furthermore, we identified 434 positional genes associated with CR. Key candidate genes include , , , and , which were previously related to heat stress responses, protein folding, and cholesterol metabolism. Furthermore, the enriched KEGG pathways and Gene Ontology (GO) terms associated with these candidate genes are linked to stress responses, immune and inflammatory responses, neural system, and DNA damage and repair. The most enriched quantitative trait loci are related to "Meat and Carcass", followed by "Production", "Reproduction", "Health", and "Exterior (conformation and appearance)" traits. Multiple genomic regions were identified associated with different CR indicators, which reveals that CR is a highly polygenic trait with small effect sizes distributed across the genome. Many heat tolerance or HS related genes in our study, such as , , and , have been identified. The complexity of CR encompasses a range of adaptive responses, from behavioral to cellular. These results highlight the possibility of selecting more heat-tolerant individuals based on the identified SNP for CR indicators. - Source: PubMed
Publication date: 2024/11/07
Wen HuiJohnson Jay SMulim Henrique AAraujo Andre CDe Carvalho Felipe ERocha Artur OHuang YijianTiezzi FrancescoMaltecca ChristianSchinckel Allan PBrito Luiz F - The aim of this study was to construct a prognostic model based on the TP53 mutation to calculate prognostic risk scores of patients with HPSCC. - Source: PubMed
Publication date: 2024/09/02
Zhang YingCui YueHao CongfanLi YingjieHe XinyangLi WenhuiYu Hongyang - miRNA is a noncoding RNA found in recent years and more than one third of human genes are the target of miRNAs. miR-624, located on human chromosome 14, is associated with tumorigenesis. However, the role of miR-624 in human hepatocarcinogenesis is still unclear. Herein, our results indicate that miR-624 accelerates the growth of liver cancer cells Moreover, the modification distribution of H3K9me1 on chromosomes is different between rLV group and rLV-miR-624 group. miR-624 affects epigenetic regulation of several genes in human liver cancer cells, such as RAB21, SMARCD3, MAPK6,PRRX1, ZFHX3, EMC3 (TMEM111). Furthermore, miR-624 affects transcriptome of some genes in liver cancer, including RAB21， UBE2N， PPP1CC，KPNA3， RAB7A，CPEB2,KLF4， MARK2， JUN， ARF6， TMEM39A. On the other hand, miR-624 affects proteome of several genes in liver cancer, such as, RBM5,PTK2, KDM2A,POLR2H, POLR2G,CDK6,KIF15,CUL2,FKBP2,ErbB-3,JUN, PKM2, CyclinE,PLK1, mTOR, PPAR, Rab7A,ARAF, UPF3B ，PTEN, SUZ12, GADD45, H3.3, CUL5, ARF6,EMC3,ATG4B,ATG14,CALR. Interestingly, miR-624 affects the RAB7A interaction network in liver cancer cells, involving in CLTC，ITGB1，HNRNPU， DARS1， RPS16， CTPS1，H3-3B，JUN,MYH10， CUL5， CPSF7. Strikingly, excessive MEC3 abrogates the carcinogenic functions of miR-624. Importantly, our findings indicate that miR-624 affects some signaling pathway in liver cancer, including Wnt signaling pathway，Hippo signaling pathway，mTOR signaling pathway, Ras signaling pathway，MAPK signaling pathway，PI3K-Akt signaling pathway, erbB signaling pathway. These results provide a basis for the treatment of human liver cancer. - Source: PubMed
Publication date: 2023/09/24
Jiang XiaoxueLu YiXie SijieChen YingjiLiu XinleiLi ShujieSong ShutingWang LiyanLu Dongdong