Ask about this productRelated genes to: POLR2G antibody
- Gene:
- POLR2G NIH gene
- Name:
- RNA polymerase II subunit G
- Previous symbol:
- -
- Synonyms:
- hRPB19, hsRPB7, RPB7
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-07
- Date modifiied:
- 2016-10-05
Related products to: POLR2G antibody
Related articles to: POLR2G antibody
- Despite its clinical importance, the metabolic landscape of MYCN nonamplified neuroblastoma (MYCN-NA NB) remains poorly defined. In this study, we performed integrated metabolic characterization of 22 NB samples by combining single-cell RNA sequencing (scRNA-seq) with proteomics and metabolomics. This was followed by multi-omics integration, two-way orthogonal partial least squares analysis, and biomarker selection using a random forest classifier. The scRNA-seq analysis of NB tumors revealed that, compared to the MYCN-amplified (MYCN-A) group, the MYCN-NA group exhibited higher proportions of T cells, monocytes, and neurons, while lipid metabolism pathways were specifically enriched. Proteomics identified 821 differentially expressed proteins [27 upregulated and 794 downregulated in the high-risk (HR) NB group], and functional analysis indicated that these proteins were primarily involved in biological processes such as the tricarboxylic acid cycle (TCA) and lipid metabolism. Metabolomics further detected 15 significantly altered metabolites associated with pathways such as linoleic acid metabolism. Integrated multiomics analysis identified key molecules, including RPL9 and POLR2G, with potentially critical roles in HR NB. Multi-omics correlation and network analyses revealed significant interactions between key proteins (RPL9 and POLR2G) and metabolites (D-ribose and 9-oxoODE). The biomarker combination determined by random forest and bidirectional orthogonal partial least squares modeling underscored the central role of oxidative lipid metabolism remodeling in high-risk disease progression. This study systematically elucidated the crucial role of lipid metabolic reprogramming in the pathogenesis of HR MYCN-NA NB. These findings provide critical insight for uncovering the mechanisms underlying NB progression and for identifying potential therapeutic targets. - Source: PubMed
Publication date: 2026/06/18
Li LizhiLin YaobinLiu ShanWang Zhihong - Gestational diabetes mellitus (GDM), one of the prevalent pregnancy-related metabolic disorders, have shown immediate or long-term adverse health outcomes for maternal and fetal health. Therefore, it is crucial to understand the ongoing cellular and molecular changes in GDM patients for characterizing novel biomarkers for diagnosis and therapeutic purposes. In the current study, we analyzed 3 transcriptomic datasets, characterized 449 unique upregulated and 785 downregulated DEGs, and performed several analyses. Gene ontology shows enrichment of migration, development, and immune-related processes in GDM patients. KEGG pathway shows enrichment of pathways like "type 1 diabetes mellitus" and "graft versus host disease". Disease ontology shows enrichment of "female reproductive system disease," "anemia," etc. Integration of methylation and transcriptomic data identified 11 genes (RASSF2, WSCD1, TNFAIP3, TPST1, UBASH3B, ZFP36, CRISPLD2, IGFBP7, TNS3, TPM2, and VTRNA1-2), as potential novel diagnostic biomarkers and therapeutic targets. Furthermore, immune cell-type infiltration analysis shows higher memory B-cells and lower M1 macrophages and CD8 T-cells. Protein-protein interaction analysis followed by ROC analysis in an independent dataset identified 7 hub genes (POLR2G, VWF, COL5A1, COL6A1, CD44, COL3A1, and COL1A1) with high diagnostic potential. Overall, we obtained 18 genes that could serve as novel diagnostic biomarkers and therapeutic targets in GDM patients. - Source: PubMed
Publication date: 2025/09/25
Mitra TridipYadav Dinesh VenkatesanKumari R SajeethaAgrawal PiyushJanardhanan Rajiv - Sepsis, like neutropenic sepsis, is a medical condition in which our body overreacts to infectious agents. It is associated with damage to normal tissues and organs by the immune system, which leads to the spread of inflammation throughout our body. Of note, microRNAs (miRNAs) have been found to have a critical role in the sepsis progression. Such miRNAs are registered in the miRNA databases, such as Gene Expression Omnibus (GEO), with a specific identifier and unique characteristics. There is also computational software, such as TargetScan, that are broadly employed for the analysis of miRNAs, including their identification, target prediction, and functional analysis. - Source: PubMed
Musavi MaryamHaftcheshmeh Saeed MohammadianFazel HadiMomtazi-Borojeni Amir Abbas - Climate change poses a growing threat to the livestock industry, impacting animal productivity, animal welfare, and farm management practices. Thus, enhancing livestock climatic resilience (CR) is becoming a key priority in various breeding programs. CR can be defined as the ability of an animal to be minimally affected or rapidly return to euthermia under thermally stressful conditions. The primary study objectives were to perform genome-wide association studies for 12 CR indicators derived from variability in longitudinal vaginal temperature in lactating sows under heat stress conditions. A total of 31 single nucleotide polymorphisms (SNPs) located on nine chromosomes were considered as significantly associated with nine CR indicators based on different thresholds. Among them, only two SNPs were simultaneously identified for different CR indicators, SSC6:16,449,770 bp and SSC7:39,254,889 bp. These results highlighted the polygenic nature of CR indicators with small effects distributed across different chromosomes. Furthermore, we identified 434 positional genes associated with CR. Key candidate genes include , , , and , which were previously related to heat stress responses, protein folding, and cholesterol metabolism. Furthermore, the enriched KEGG pathways and Gene Ontology (GO) terms associated with these candidate genes are linked to stress responses, immune and inflammatory responses, neural system, and DNA damage and repair. The most enriched quantitative trait loci are related to "Meat and Carcass", followed by "Production", "Reproduction", "Health", and "Exterior (conformation and appearance)" traits. Multiple genomic regions were identified associated with different CR indicators, which reveals that CR is a highly polygenic trait with small effect sizes distributed across the genome. Many heat tolerance or HS related genes in our study, such as , , and , have been identified. The complexity of CR encompasses a range of adaptive responses, from behavioral to cellular. These results highlight the possibility of selecting more heat-tolerant individuals based on the identified SNP for CR indicators. - Source: PubMed
Publication date: 2024/11/07
Wen HuiJohnson Jay SMulim Henrique AAraujo Andre CDe Carvalho Felipe ERocha Artur OHuang YijianTiezzi FrancescoMaltecca ChristianSchinckel Allan PBrito Luiz F - The aim of this study was to construct a prognostic model based on the TP53 mutation to calculate prognostic risk scores of patients with HPSCC. - Source: PubMed
Publication date: 2024/09/02
Zhang YingCui YueHao CongfanLi YingjieHe XinyangLi WenhuiYu Hongyang