Ask about this productRelated genes to: ARNTL antibody
- Gene:
- ARNTL NIH gene
- Name:
- aryl hydrocarbon receptor nuclear translocator like
- Previous symbol:
- -
- Synonyms:
- MOP3, JAP3, BMAL1, PASD3, bHLHe5
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-06
- Date modifiied:
- 2017-08-18
Related products to: ARNTL antibody
Related articles to: ARNTL antibody
- Growing evidence indicates that dysregulation of circadian clock genes and cell cycle regulators plays a role in the pathogenesis of malignancies. BMAL1, a core circadian clock gene, and WEE1, a key regulator of the G2/M cell cycle checkpoint, are involved in controlling cell proliferation and maintaining genomic stability. The present study aimed to evaluate the expression pattern of these two genes in children with acute myeloid leukemia. - Source: PubMed
Publication date: 2026/09/25
Oraei Sajjadi KimiaAyatollahi HosseinSheikhi MaryamAhmadi Mohammad Hossein - Brain and muscle ARNT‑like 1 (BMAL1) is a core transcription factor of the molecular circadian clock and links daily timing with cardiovascular electrophysiology, metabolism, vascular function and inflammation. Altered BMAL1 expression or rhythmicity has been reported in arrhythmias, atherosclerosis, myocardial ischemia/reperfusion injury and heart failure. However, its specific role has remained elusive, as local effects in cardiovascular cells are often mixed with the broader effects of whole‑body circadian disruption. The present review addressed this gap by separating evidence from central and peripheral clocks, cell‑specific and systemic models, and experimental and human studies. Cardiomyocyte‑specific models provide relatively direct evidence that the local clock supports electrical stability, substrate use, mitochondrial homeostasis and contractile function. However, in endothelial cells, vascular smooth muscle cells and immune cells, the effects of BMAL1 are more variable and depend on cell type, metabolic conditions, disease stage and circadian phase. Human evidence remains mainly associative, whereas most mechanistic findings come from cell and animal studies. The present review also assessed small‑molecule clock modulators, chronotherapy and non‑pharmacological interventions, as well as time‑resolved multi‑omics and machine‑learning approaches. Current evidence does not support viewing BMAL1 as simply protective or harmful. A selective BMAL1‑binding small molecule has recently been identified, but its cardiovascular efficacy and safety have not been established. In addition, the clinical benefits of chronotherapy vary across treatments and patients. Further translation will require tissue‑specific human models, repeated sampling across biological time and prospective studies of treatment guided by individual circadian phases. - Source: PubMed
Publication date: 2026/09/25
Liang YuChen TingjinWen XuemeiLiu DanZhang ZhongjianLi WeiqingZhang Hengdi - This study investigated the genetic basis of growth, carcass, and meat quality traits in Yanying chickens, an indigenous breed adapted to high-altitude environments. A total of 19 growth traits and 29 carcass and meat quality traits were measured, and genome-wide association study (GWAS) was performed to identify loci associated with these economically important traits. In total, 455 significant single nucleotide polymorphisms (SNPs) were identified, and 176 candidate genes were obtained. Among these, 1 had been directly associated with the corresponding trait in previous chicken studies, while approximately 5 others had been implicated in related traits. Further regional association and linkage disequilibrium (LD) analyses highlighted RYR2 and ARNTL as positional candidate genes associated with spleen weight and breast muscle pH, respectively. In addition, expression-based analysis provided additional evidence consistent with ARNTL being a positional candidate gene for breast muscle pH. Functional enrichment analysis identified significant Gene Ontology (GO) terms related to cell adhesion and calcium ion binding, whereas Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested nominal enrichment of ECM-receptor interaction and MAPK signaling pathways. Overall, these findings provide new insight into the genetic architecture of growth, carcass, and meat quality traits in this indigenous breed and offer useful information for future functional validation and genetic improvement of local poultry populations. - Source: PubMed
Publication date: 2026/09/12
He YuhangWang QiangLi JingheYang MingZou JunChen YuqiZhao JianianJiang JianxingLiu RuxueWei XinyuYuan XiaochanZheng ZhaoyouTan XiyuXiang QiaoHuang JianfengTong RenboLiu HeheHuang Anqi - Severe burns cause systemic inflammation and a hypermetabolic response, yet their impact on biorhythms remains unclear. Clock gene-regulated circadian rhythms maintain physiologic homeostasis and are altered in disease. We posit that severe burn disrupts tissue-specific clock gene expression in peripheral blood mononuclear cells and is associated with molecular alterations in skeletal muscle. - Source: PubMed
Publication date: 2026/09/22
Kleinhapl JuliaValdez RitoWolf StevenSong Juquan - Chronic kidney disease (CKD) is driven by inflammation, fibrosis, and metabolic dysfunction. While circadian rhythm dysregulation is well documented in chronic disorders, its specific impact on CKD pathogenesis remains elusive. - Source: PubMed
Publication date: 2026/09/06
Li Xiao-QianCheng LeiChen Tian-FenMa Yi-NuoLi Xiao-HuiFu Ting-YuXiao JingZhao Zhan-Zheng