Ask about this productRelated genes to: CLOCK antibody
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: CLOCK antibody
Related articles to: CLOCK antibody
- - Source: PubMed
Publication date: 2026/04/22
Harbeck NModi SPusztai LBoileau J-F - The razor clam Sinonovacula constricta is an economically important cultivated bivalve. Unlike other bivalve species, S. constricta spawns exclusively at night, suggesting potential endogenous circadian regulation of spawning. To investigate this, we identified circadian clock (period circadian, per) and inflammation-related genes, such as the nuclear factor-κB (nf-κb), inhibitor of NF-κB kinase (iκk), tumor necrosis factor receptor 3 (traf3), B-cell lymphoma-2 (bcl2), and caspase 6 (casp6), which were screened from transcriptome data across four diurnal time points (00:00/ZT16, 06:00/ZT22, 12:00/ZT28, 18:00/ZT34) in S. constricta. Both per and these inflammation-related genes were highly expressed during the light cycle. Furthermore, both their expression levels and corresponding proinflammatory mediator content were significantly higher in the spawning group than the control group. Additionally, interference with the per gene upregulated the expression levels of several inflammation-related genes with predicted E-box motifs in their promoter regions. These findings suggest that the circadian clock may modulate inflammatory responses and proinflammatory factors by rhythmically expressing, thereby influencing spawning behavior in razor clams. This study establishes a foundation for understanding circadian regulatory mechanisms and provides valuable insights into the role of inflammatory responses in molluscan reproduction. - Source: PubMed
Publication date: 2026/05/14
Gu ZefengLu JinzhaoBian QihaoYao HanhanZhang WeiweiDong Yinghui - A review of mutation mechanisms across a range of organisms (including viruses, bacteria, insects, animals, and humans) has been performed. Considering the complexity of their genomes and population sizes, it is concluded that mutations leading to the emergence of beneficial adaptations are not random but are instead regulated processes. While some mutations occur randomly and can be used to reconstruct phylogenetic trees, this does not imply that they generate new species. New species arise as a result of non-random genomic changes that have a high degree of protection against chance. Random mutations tend to occur in regions of the genome that are less protected from such changes. Thus, evolution is not a random process but is governed by the principles that regulate biologically important molecules and organisms as a whole. In the frame of the systems approach mathematical model has been proposed, that incorporates both random and regulated processes. - Source: PubMed
Publication date: 2026/05/14
Melkikh A V - Ageing is an inevitable, yet highly heterogeneous process shaped by genetic, epigenetic, and environmental influences. While most individuals experience progressive functional decline, a minority exhibits accelerated degeneration due to rare pathogenic mutations, whereas others achieve exceptional healthy longevity. This continuum-from progeroid syndromes to centenarians-provides a unique framework to examine how deleterious and protective genetic variants differentially modulate conserved biological pathways. Genetic models of accelerated ageing reveal mechanisms driving premature functional deterioration, whereas studies of exceptionally long-lived individuals highlight variants associated with resilience, stress adaptation, and preserved homeostasis. Together, these extremes define a genetic dichotomy that informs, but does not deterministically predict, ageing trajectories. This review critically highlights current evidence on genetic factors and molecular mechanisms that regulate human ageing across this spectrum. Beyond established hallmarks such as cellular senescence and chronic inflammation, we discuss emerging pathways implicated in successful ageing, including hypoxic adaptation, transcriptional and chromatin regulation, autophagy, and metabolic reprogramming. We further evaluate epigenetic clocks as quantitative tools for assessing biological ageing, emphasising their strengths, limitations, and context dependence. Throughout, we distinguish between genetic associations, mechanistic findings, and preclinical evidence, explicitly addressing gaps, biases, and translational uncertainty. This synthesis was conducted using a qualitative narrative review approach integrating human genetic data, mechanistic studies, and translational evidence across models of accelerated and successful ageing. - Source: PubMed
Publication date: 2026/05/14
Cattaneo MonicaCarnevali SaraMadeddu PaoloPuca Annibale A - Atypical atrioventricular nodal reentrant tachycardia (AVNRT) is characterized by heterogeneous reentrant circuits, and substrate-oriented ablation targets remain incompletely defined because retrograde slow pathway atrial exits are spatially variable. - Source: PubMed
Publication date: 2026/05/14
Takahashi MasaoMizunuma YoshiakiSasaki TakafumiYamaoka KoichiroKujiraoka HirofumiArai TomoyukiHojo RintaroFukamizu Seiji