Ask about this productRelated genes to: E2F1 antibody
- Gene:
- E2F1 NIH gene
- Name:
- E2F transcription factor 1
- Previous symbol:
- RBBP3
- Synonyms:
- RBP3
- Chromosome:
- 20q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-29
- Date modifiied:
- 2016-10-05
Related products to: E2F1 antibody
Related articles to: E2F1 antibody
- The metabolic enzyme lactate dehydrogenase C4 (LDHC4) is aberrantly expressed in cancers and linked to poor prognosis. However, its role in lung adenocarcinoma (LUAD) and the molecular mechanisms beyond glycolysis remain unclear. This study investigates whether LDHC4 promotes LUAD by modulating protein lactylation, a lactate-derived post-translational modification, focusing on the tumor suppressor retinoblastoma protein (RB1). - Source: PubMed
Publication date: 2026/05/02
Peng WeiLin ZhiSun ChengLin LingjingCui ZhaoleiLin Donghong - This study aimed to examine the clinical characteristics of patients with fixed airflow obstruction (FAO) during acute asthma exacerbations, with a focus on quantifying E2F1 expression in peripheral blood and induced sputum. Our objective was to assess its potential role as a biomarker for airway remodeling in asthma. - Source: PubMed
Publication date: 2026/04/30
Liu AnqiDai JunjieLiu YaqinZhan JiankangBai ChengwenWu YingHe JiaWu MinnaShi Fei - The high toxicity of current therapies and frequent relapse in mature B-cell non-Hodgkin lymphomas (B-NHLs) reveal a substantial unmet clinical need for more effective targeted treatment strategies. To address this gap, Gene Set Enrichment Analysis (GSEA) of B-NHL datasets was conducted, uncovering marked enrichment of E2F transcription factors and their target genes. Despite the central role of E2F signaling in cell cycle control and oncogenesis, its contribution to pediatric B-NHLs has not been systematically characterized. Accordingly, we performed a comprehensive analysis of E2F signaling and its downstream targets to identify potential therapeutic and prognostic biomarkers in pediatric B-NHLs. - Source: PubMed
Publication date: 2026/04/27
Liu Si-YingZhang De-DongWang Ya-QinYu WenWang LiZhang Jia-SiLiu Ai-Guo - Triptolide (TPL), the core active component of the traditional Chinese medicinal herb Hook F (TwHF), possesses a wide spectrum of pharmacological activities, including anti-inflammatory, neuroprotective, immunosuppressive, and anti-tumor activities. However, its clinical application is severely limited by significant reproductive toxicity, the mechanism of which remains poorly understood. Using an integrated analysis of MeRIP-seq and mRNA-seq data, coupled with experimental validation in HTR-8/SVneo cells, we systematically elucidated the molecular mechanism by which TPL induces trophoblast cell injury. Our findings revealed that TPL significantly altered intracellular N-methyladenosine (mA) modification and gene expression profiles, with 1774 genes displaying hypomethylation concurrent with mRNA upregulation. According to the functional enrichment analysis, these genes showed significant enrichment in several key pathways associated with reproduction, including autophagy, DNA damage response, mitochondrial outer membrane, and positive regulation of apoptotic process. Molecular docking further demonstrated direct and stable binding of TPL to key mA regulators, leading to specific demethylation of targets including and . This study uncovers a novel post-transcriptional mechanism where TPL disrupts mA modification, thereby perturbing essential trophoblast functions and driving reproductive toxicity. - Source: PubMed
Publication date: 2026/04/16
Liu XinruWu YunliTian JinWen JiaxinShi YuanWang LiliZhu AnWu Zekai - Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by impaired differentiation and accumulation of immature myeloid cells. Aurora kinases and their regulatory genes play key roles in mitotic progression and may contribute to leukemogenesis. This study aimed to evaluate the expression and promoter methylation status of , , and and their regulatory genes, , , and in AML. Peripheral blood samples from 83 AML patients and 28 age- and sex-matched healthy controls were analyzed using MIQE-compliant RT-qPCR for gene expression and MSRE-qPCR for promoter methylation. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Expression levels of , , , and were significantly increased in AML patients ( < 0.001), whereas expression was significantly reduced ( = 0.001), and showed no significant difference. Promoter methylation analysis revealed significantly increased methylation in AML ( < 0.001), decreased methylation ( = 0.023), and no significant change in . ROC analysis demonstrated strong diagnostic performance, with showing the highest accuracy (AUC = 0.95), while a combined biomarker panel achieved an AUC of 0.96. Aurora kinase-related genes are dysregulated in AML and may serve as preliminary peripheral biomarker candidates. However, further validation in independent cohorts and more refined cellular models is required before clinical application. - Source: PubMed
Publication date: 2026/04/05
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