Ask about this productRelated genes to: CIB2 antibody
- Gene:
- CIB2 NIH gene
- Name:
- calcium and integrin binding family member 2
- Previous symbol:
- DFNB48, USH1J
- Synonyms:
- KIP2
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2016-10-05
Related products to: CIB2 antibody
Related articles to: CIB2 antibody
- Recent decades have seen noticeable warming, causing in mid and high latitudes longer growing season, more summer droughts, and decreased spring vernalization, prompting plant breeders to focus on improving plant adaptation to these new conditions. One of the key traits is responsiveness to vernalization, a typical characteristic of temperate grain legumes, including yellow lupin ( L.), a potential European alternative to soybeans for sandy soils. Although beneficial for autumn sowing in warmer areas, vernalization responsiveness can be unfavorable for spring sowing due to delayed flowering. To facilitate studies on genetics of vernalization responsiveness in yellow lupin, a recombinant inbred line (RIL) population was developed from a cross between a thermoneutral, rapid flowering breeding line PRH444/14 and a vernalization-responsive, moderately late flowering cultivar, Parys. The RILs were phenotyped in a greenhouse under ambient long-day photoperiod across three spring seasons (2022-2024) and short-day photoperiod during the winter season (2023/4). The difference in flowering time between early and late RILs reached ~39 days in long days and ~68 days in short days. Following DArT-seq genotyping, a linkage map comprising 1,448 loci and anchoring all yellow lupin pseudochromosomes was constructed. Despite moderate fragmentation of the map (63 linkage groups versus 26 chromosomes), there was a high level of collinearity. Composite interval mapping of flowering-related traits identified a major quantitative trait locus (QTL), significant throughout all years and in both photoperiods, located on chromosome YL-16 and explaining up to 34% of the phenotypic variance. This QTL co-localized with a gene, one of the four () homologues from the yellow lupin genome. The marker developed for the 2,227 bp indel from the promoter exhibited the highest correlation with plant phenology among all markers on this linkage map. Additionally, several minor QTLs were identified on other chromosomes, including one on chromosome YL-04, significant under long-day photoperiod and explaining up to 5% of phenotypic variance, and another on chromosome YL-14, specific to the short-day photoperiod, accounting for up to 9%. Candidate genes for these QTLs include known flowering time regulators, such as and genes for YL-04, and for YL-14. - Source: PubMed
Publication date: 2026/04/23
Dogra IshaniEldho-Paul AllenSurma AnnaRychel-Bielska SandraBielski WojciechKozak BartoszKsiążkiewicz Michał - Sexual maturation in boars impacts reproductive efficiency in swine production, yet the molecular mechanisms underlying this developmental transition remain poorly understood. This study aimed to investigate the transcriptomic changes in sperm from Duroc boars during sexual maturation, conducting a longitudinal analysis. The total RNA and miRNA profiles from the same individuals (n = 6) at puberty (7.24 ± 0.39 months) and sexual maturity (10 ± 0.40 months) were compared, identifying molecular signatures associated with reproductive development. Total RNA sequencing (Illumina NovaSeq-6000) and miRNA sequencing (Illumina NextSeq-500) were performed on all 12 paired samples (6 boars at 2 time points), followed by differential expression analysis using a paired statistical model in DESeq2 to account for repeated measures. - Source: PubMed
Publication date: 2026/01/21
Shrestha Asmitavan Son MarenHashim AdnanRouzbehani SoudabehGilfillan Gregor DBerge UrszulaKommisrud ElisabethAlm-Kristiansen Anne Hege - Nile tilapia (Oreochromis niloticus) is a widely farmed freshwater fish. Feeding with faba bean (Vicia faba L.) for 90-120 days can improve the muscle quality of tilapia. However, the underlying mechanism remain unclear. In the present study, tilapia were fed a faba bean-based diet for 120 days to induce muscle crisped, and ordinary tilapia fed a conventional diet were used as controls. Muscle histological characteristics were evaluated using hematoxylin and eosin staining, and transcriptome sequencing was conducted to explore molecular changes associated with the crisped muscle phenotype. The results showed that, as compared to ordinary tilapia, the fiber diameter and area were significantly reduced in crisped tilapia (p < 0.05), while the muscle fiber density was significantly increased (p < 0.05). In total, 576 differentially expressed genes (DEGs) were identified (FDR < 0.05), of which 211 were significantly up-regulated and 365 significantly down-regulated. Further analysis showed that DEGs associated with myofibroblast proliferation were up-regulated in crisped tilapia, while the glycolytic pathway was inhibited. The expression levels of muscle-related genes (i.e., actc1, myo7a, cib2, abcf2, and pfkfb2) were significantly higher in crisped tilapia than ordinary tilapia (p < 0.05), whereas the expression levels of gapdh, pgam2, eno3, and g6pi were significantly decreased (p < 0.05). Several DEGs and signaling pathways were identified. These findings provide transcriptomic evidence linking dietary faba bean feeding to muscle fiber remodeling and metabolic modulation in tilapia, offering a molecular basis for improving fillet quality through nutritional strategies. - Source: PubMed
Publication date: 2026/01/08
Li QingqingHuang YaoXie XiLiang ShaowenLin Li - Mouse models are relevant to study functionality of genes involved in human hearing and vestibular disorders; however, other pre-clinical models including organoids could be more suitable depending on the gene and its homology across species. While some mouse models replicate human hearing phenotypes, models for vestibular disorders like Meniere Disease (MD) are lacking. We aimed to identify genes associated with auditory and vestibular phenotypes (AVP) in humans and mice to prioritize candidate genes for further MD research. A systematic review was conducted extracting data from PubMed, Scopus, the International Mouse Phenotyping Consortium (IMPC), and the Deafness Variation Database (DVD). We included studies reporting AVP linked to genetic variants in human, mice or both. A total of 31 interspecies auditory phenotype genes shared between the IMPC and DVD, of which 25 were expressed in both cochlear and vestibular tissues. Five were prioritized as AVP candidates—. IMPC screening also revealed 52 mouse hearing loss genes, several with strong cochlear and vestibular expression not previously described. Integrating phenotypic and expression data highlighted and as promising candidates for MD. Vestibular phenotyping is underrepresented in current KO mouse models, as vestibular function is not systematically tested in the IMPC pipeline, leading to incomplete annotation of vestibular phenotypes. Comprehensive vestibular assessments in IMPC pipelines and targeted vestibular phenotype evaluation of individuals with rare variants in DVD genes are essential to advance translational vestibular research. - Source: PubMed
Publication date: 2025/12/22
Ayoub CedraPaladugu SaihamsiniNikitenko NikitaLopez-Escamez Jose A - Usher syndrome is characterized by congenital sensorineural hearing loss, retinitis pigmentosa, and vestibular dysfunction. It is the most common cause of deafblindness worldwide. It is classified into three clinical types and twelve genetic subtypes. We report a case of a family affected by Usher syndrome due to a variant in the USH1G gene, coding for the SANS protein. The ocular and auditory tests were performed for clinical confirmation of the diagnosis. The molecular study consisted of a next-generation sequencing panel containing 14 genes associated with Usher syndrome: MYO7A, USHC1, CDH23, PCDH15, USHG1, CIB2, USH2A, ADGRV1, WHRN, CLRN1, HARS, PDZD7, CEP250, C2orf71. We present the case of a 13-year-old girl from a consanguineous Colombian family diagnosed with Usher syndrome type 1G. Clinical evaluations confirmed auditory, vestibular, and ocular alterations. Molecular analysis identified the homozygous p.Glu171Ter variant in the USH1G gene. We highlight the importance of an early diagnosis of Usher syndrome. Although the variant frequency in the USH1G gene is low, it should not be underestimated; the exact etiology must be identified in these families. We recommend establishing a panel with Colombianspecific variants to perform more accurate Usher syndrome diagnoses, and in the future, to guide the development of gene therapies. - Source: PubMed
Publication date: 2025/09/22
Gélvez NancyLópez GreizyTamayo Marta L