Ask about this productRelated genes to: PAX8 antibody
- Gene:
- PAX8 NIH gene
- Name:
- paired box 8
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-16
- Date modifiied:
- 2017-07-07
Related products to: PAX8 antibody
Related articles to: PAX8 antibody
- Clear cell renal cell carcinoma (ccRCC) is the most frequent kidney cancer, and its clinical course has been improved by the development of new anticancer immunotherapies. A rare variant of ccRCC is characterized by the presence of syncytial giant cells (SGCs), whose biological significance remains unclear. This study aimed to report a case of ccRCC with SGCs and to characterize its immune microenvironment. - Source: PubMed
Ozaki YojiroImafuji JunnosukeUekawa AyanoIbe YukiZhao ShukangYamada RinNakamura KeisukeMurakami YojiYatsuda JunjiBeppu ToruKomohara YoshihiroKamba Tomomi - The coexistence of benign mesonephric-like proliferation (MLP), mesonephric-like hyperplasia (MLH), and mesonephric-like adenocarcinoma (MLA) with ovarian mucinous cystadenoma or mucinous borderline tumor (MBT) has been previously reported; however, this phenomenon is exceedingly rare, and understanding of the pathology and biology remains limited. Here we report additional cases, with an emphasis on expanded observations and novel pathologic features. This series included 9 cases: (1) 2 cases of mixed MLA and endometrioid adenocarcinoma associated with cystic mucinous neoplasm of lower gastrointestinal (GI) type (case 1) or mucinous cystadenoma (case 2); (2) 1 case of MLA associated with MBT and mucinous adenocarcinoma (case 3); (3) 4 cases of MLA associated with MBT (cases 4 and 5) or mucinous cystadenoma (cases 6 and 7); and (4) 2 cases of MLP/MLH associated with MBT (cases 8 and 9). All mesonephric-like lesions were diffusely positive for PAX8 and either diffusely (7 cases) or focally (2 cases) positive for GATA3. Focal TTF-1 expression was observed in 4 cases (4/9, 44.4%). All mucinous tumors, except for case 1, showed either focal (4 cases) or diffuse (4 cases) PAX8 positivity. Molecular analysis in case 1 revealed a common KRAS p.G12A driver mutation in all 3 tumor components (MLA, endometrioid adenocarcinoma, and mucinous tumor), indicating clonal relatedness. In contrast, pathogenic somatic mutations in ARID1A, DNMT3A, PIK3CA, and TET2 were detected only in the MLA and endometrioid adenocarcinoma, but not in the mucinous tumor component, suggesting lineage-specific differentiation. Notably, case 1 represents the first reported example of a mesonephric-like lesion associated with a mucinous tumor exhibiting lower GI morphology and immunophenotype. Case 3 represents the first case with mucinous adenocarcinoma in this scenario. Case 9 represents the first reported instance in which both ovaries were independently involved by MLP/MLH and MBT. The presence of benign MLP/MLH alongside MLA suggests that the former may represent noncancerous precursor lesions with the potential to develop into MLA; they may represent benign (MLP) or borderline (MLH) mesonephric-like lesions. Whether mesonephric-like lesions serve as precursors of ovarian mucinous tumors remains debated, but their coexistence in the ovary, as documented in 20 cases to date (including previously published cases and the current series), may represent a unique biological process and provide an ideal model for investigating mechanisms of transdifferentiation and tumorigenesis. - Source: PubMed
Publication date: 2026/05/27
Smith ColtonDudley JonathanSavage JohannaVan de Vijver KoenHong LiuSong WeihuaKir GözdeKearns KaterinaShakiba DelaramAdamson Kathi HSmith Saron AWang YunLiu MeiLiu AijunVang RussellMcCluggage W GlennXing Deyin - Non-intestinal type sinonasal adenocarcinomas (non-ITACs) are rare entities with a wide range of histologic appearances. In this study we characterize the clinico-pathologic, immunohistochemical and molecular features of six cases of sinonasal adenocarcinoma with clear cell morphology, identified retrospectively in our files and occurring in 2 females and 4 males, with mean age of 62.6 years. Immunohistochemical and molecular studies including RNA sequencing, were performed. All cases showed a proliferation of epithelioid clear cells with slight to moderate atypia, arranged in variable patterns. Two cases had the typical histologic appearance and immunohistochemical profile of sinonasal renal cell-like adenocarcinoma, being formed of follicular structures and solid nests containing eosinophilic colloid-like material, with diffuse positivity for SOX10, carbonic anhydrase IX (CAIX), S100, and cytokeratin 7. One further case had a similar histologic appearance but lacked positivity for CAIX and S100. A previously unreported ETV6::YEATS4 rearrangement was detected by RNA sequencing in this case. Two adenocarcinomas showed mixed tubulo-papillary and acinar architecture with clear cell foci, including areas reminiscent of renal cell-like adenocarcinoma. Finally, one case had a tubulo-cystic appearance with clear cells and a surface component presenting ciliated, papillary and squamoid areas. This adenocarcinoma presented a MAP2K1 p.Gln56Pro; c.167 A > C mutation. Immunohistochemically, all cases were strongly positive for pancytokeratin and cytokeratin 7, SOX10 was positive in all cases tested (5/5), whereas S100 was positive in 4/6 cases and DOG1 in 1/3 cases. Notably, basal/myoepithelial markers and renal cell carcinoma markers, including CD10, PAX8 and RCC, were negative in all cases. Sinonasal adenocarcinomas with clear cell features are a heterogenous group of neoplasms in the spectrum of low-grade non-ITAC that must be differentiated from primary salivary-type sinonasal adenocarcinomas and from metastatic carcinomas. The differential diagnosis requires the support of an immunohistochemical panel, as well as molecular testing in selected cases. - Source: PubMed
Publication date: 2026/05/27
Franchi AlessandroDin Nasir Udvan den Hout MariArcovito GiorgiaDallan IacopoScarpitta RosaStoehr RobertAgaimy Abbas - Gallbladder metastasis from renal cell carcinoma is rare, and synchronous para-aortic lymph node metastasis has been scarcely reported. An 83-year-old man who had undergone laparoscopic right nephrectomy previously was found to have a polypoid gallbladder lesion and an enlarged para-aortic lymph node. Endoscopic ultrasound-guided fine-needle aspiration of the lymph node revealed atypical clear cells positive for AE1/3, renal cell carcinoma marker, and PAX8. Laparoscopic full-thickness cholecystectomy and targeted excision of the para-aortic lymph node were performed. Histopathology confirmed metastatic clear cell renal cell carcinoma in both lesions. Recovery was uneventful, without chyle leak. He remains recurrence-free at 6 months. This case demonstrates the technical feasibility and short-term safety of a totally laparoscopic approach. - Source: PubMed
Kuno YasutakaMatsumura MasaruSekimoto MasahiroOkada TakumaOkubo SatoshiKuge GakuIkemura MasakoShindoh JunichiHashimoto Masaji - Cardiac masses identified on echocardiography can pose significant diagnostic challenges, particularly when differentiating between thrombi and vegetations, which require markedly different management approaches. We present the case of a 57-year-old postmenopausal woman with a history of thymic cancer and recent pulmonary embolism (PE), who presented with abdominal pain, weight loss, and laboratory findings consistent with disseminated intravascular coagulation (DIC). Abdominal ultrasound and magnetic resonance imaging (MRI) revealed a large fibroid uterus with multiple masses concerning for leiomyosarcoma or leiomyoma, and transthoracic echocardiography (TTE) showed a large echo density on the tricuspid valve and a bicuspid aortic valve with mild-to-moderate stenosis. Further evaluation with transesophageal echocardiography (TEE) confirmed a large mass on the tricuspid valve and also revealed multiple echo densities on the mitral and aortic valves. Cardiac MRI (CMR) demonstrated thickened, mobile tricuspid valve leaflets with moderate regurgitation; mild-to-moderate mitral regurgitation was also seen, along with thickening of the mitral valve leaflets. However, the nature of the masses remained unclear. Despite negative blood cultures, the clinical and imaging findings raised suspicion for non-bacterial thrombotic endocarditis (NBTE), though thrombi remained a differential consideration. Given the patient's hypercoagulable state, a multidisciplinary team initiated anticoagulation and arranged close outpatient follow-up. A cervical lymph node biopsy subsequently confirmed metastatic, poorly differentiated carcinoma with immunohistochemistry positive for CKAE1/AE3, HMWCK, and PAX8, suggesting either recurrent thymic malignancy or a primary uterine origin. A few months later, repeat TTE showed reduced severity of mitral and tricuspid regurgitation, and the valvular masses were less apparent. The patient is currently undergoing palliative chemotherapy with carboplatin, paclitaxel, and dostarlimab, continues on lifelong anticoagulation, and receives comprehensive pain management. This case underscores the diagnostic complexity of cardiac masses, particularly in patients with malignancy. It highlights the critical role that multimodality imaging plays in resolving complex diagnostic dilemmas and emphasizes the importance of a collaborative approach in managing such patients. - Source: PubMed
Publication date: 2026/04/18
Kazi AhmedSaleem AniqAkram Abeera