Ask about this productRelated genes to: PAX8 antibody
- Gene:
- PAX8 NIH gene
- Name:
- paired box 8
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-16
- Date modifiied:
- 2017-07-07
Related products to: PAX8 antibody
Related articles to: PAX8 antibody
- High-grade squamous intraepithelial lesion (HSIL) is a precancerous condition of the cervix. Identifying risk factors associated with HSIL and understanding their potential mechanisms may inform prevention strategies. This study aimed to investigate the associations of genetically predicted gene expression and circulating metabolites with HSIL risk using Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/09/01
Cui BozhouDing YanLi FeixiaHu TuoyangZhu JiaojiaoChang XiaoyingWang YucunYang JieCui Jing - Renal cell carcinoma (RCC), comprising approximately 5% of adult malignancies, exhibits diverse morphologic and immunophenotypic features at primary and metastatic sites. Approximately one-third of patients present with metastatic disease at the time of diagnosis, and another 40% go on to develop metastases after nephrectomy. Accurate cytologic diagnosis of metastatic RCC is critical for prognosis, especially when tissue samples are limited. Few studies have evaluated concordance between primary RCC resections and matched metastatic cytology specimens. We evaluated morphologic and immunophenotypic concordances between primary RCCs and matched cytology specimens. - Source: PubMed
Publication date: 2026/07/24
Marshall MasonLajara SigfredQuiroga-Garza GabrielaKop MichaelaKorentzelos DimitriosKhader Samer - Primary extrarenal nephroblastoma, or extrarenal Wilms tumor, is an exceptionally rare embryonal tumor outside the kidney. Spinal/lumbosacral involvement is particularly uncommon and may mimic congenital dysraphic lesions. We report a 10-month-old female infant followed since birth for presumed sacral lipoma and operated on for suspected meningomyelocele/lipomeningocele. Imaging demonstrated a solid S1 to S3 lesion adjacent to a thin lipomatous lesion near the conus medullaris. Histopathology unexpectedly showed a blastemal-predominant triphasic nephroblastoma with epithelial differentiation and limited stromal component. Tumor cells were diffusely positive for nuclear WT1 and PAX8. Normal bilateral kidneys, absence of teratomatous component, and negative metastatic work-up supported primary localized extrarenal disease. Complete excision was followed by vincristine/actinomycin-D-based chemotherapy; 6-month imaging showed no residual or recurrent lesion. - Source: PubMed
Publication date: 2026/09/04
Yetişgin EfeEmrahoğlu Muhammed ErkanYılmaz ŞükriyeYeşil ŞuleÖnder Evrim - Pseudomyxoma peritonei (PMP), which involves both the ovaries and appendix, is usually attributed to an appendiceal primary tumor with secondary involvement. However, rare cases may present with synchronous, independent mucinous primaries. Distinguishing between these entities is important because staging, treatment, prognosis, and follow-up may differ according to the primary site. An 83-year-old woman presented with abdominal distension and ascites incidentally discovered during an evaluation for traumatic intracranial hemorrhage. Computed tomography revealed large-volume ascites, a large multilocular cystic mass arising from the left ovary, and a dilated appendix. Diagnostic laparoscopy confirmed the presence of gelatinous ascites, which was consistent with PMP. Histopathological examination revealed ovarian mucinous carcinoma and appendiceal mucinous neoplasms. Immunohistochemistry showed discordant profiles for ovarian (cytokeratin [CK]-7+/paired box 8 [PAX8]+/CK-20-/caudal-type homeobox 2 [CDX-2]-) and appendiceal (CK-20+/CDX-2+/CK-7-/PAX8-) lesions. Peritoneal tumor cells expressed CK-7 but lacked PAX8, CK-20, and CDX-2 expression, supporting an ovarian-type immunophenotype of the peritoneal disease. The patient underwent diagnostic laparoscopy with left salpingo-oophorectomy and removal of the gelatinous ascites. Two cycles of paclitaxel and carboplatin were administered before interval cytoreductive surgery because of advanced disease, arrhythmia, and poor tolerance to prolonged surgery. Complete cytoreduction was achieved through total hysterectomy, right salpingo-oophorectomy, appendectomy, total parietal peritonectomy, omentectomy, cholecystectomy, splenectomy, and the removal of visible disease, followed by carboplatin monotherapy. Complete cytoreduction was achieved, and the patient completed adjuvant carboplatin therapy without grade 3 or higher adverse effects. The patient remained disease-free for 6 months after the completion of chemotherapy. - Source: PubMed
Publication date: 2026/09/04
Koo JiyeonNgo Long HoangKim Mi-KyungRyu Rae RimCho Sang HyunHan Gwan HeeLee Eun-Ju - Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injured PT cells, suggesting activation of the ubiquitin-proteasome system during tubular stress. Because Cullin 3 (CUL3), scaffold of ubiquitin ligases, regulates oxidative stress signaling through the KEAP1-NRF2 axis, we investigated its role in PT injury and stress adaptation. - Source: PubMed
Publication date: 2026/09/02
Saritas TurgayChen LuIjaz SadafZiegler SusanneDugourd AurélienShao XiaohangUlrich JonathanKoenig ClaireFranciosa GiuliaPiga IlariaOlsen Jesper VSchneider-Kramann RebekkaMcCormick James AHayat SikanderKramann Rafael