Ask about this productRelated genes to: LHX2 antibody
- Gene:
- LHX2 NIH gene
- Name:
- LIM homeobox 2
- Previous symbol:
- -
- Synonyms:
- LH-2, hLhx2
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-15
- Date modifiied:
- 2014-11-19
Related products to: LHX2 antibody
Related articles to: LHX2 antibody
- Spinal commissural neurons play a fundamental role in motor control and sensory perception. Robo3, a receptor expressed on pre-crossing commissural axons, is required for midline crossing. Its downregulation in post-crossing axons is essential for forming synapses with contralateral CNS targets. We demonstrate that, at the transcriptional level, the dynamic expression of in pre-crossing neurons is controlled by incoherent feedforward loops (iFFLs) and negative feedback loops (NFLs) that precisely regulate its transience and thereby determine midline crossing. Lhx2 and Lhx9 activate while also inducing its repressor, Barhl2. Additionally, NFLs fine-tune the transience of expression by adjusting the relative strength of the activation and repression modules. Our genomic analysis reveals that this regulatory circuitry converges on an enhancer element of the gene. These findings imply that diverse iFFLs, together with NFLs, are essential for regulating the extent of midline crossing across different spinal commissural subtypes. - Source: PubMed
Publication date: 2026/04/28
Sudakevitz-Merzbach ReutMajumder MadhuriElberg GerardBakhtan MarahRekler DinaKhazanov SophieWheaton Benjamin JoelBen-Arie NissimFriedlander GilgiKalcheim ChayaWilson Sara IvyJaworski AlexanderAdler MiriKlar Avihu - Breast cancer progression reflects heterogeneous malignant states shaped by clonal evolution and microenvironmental selection, yet how genomic instability quantitatively couples to transcriptional state transitions and spatial niche organization remains unclear. - Source: PubMed
Publication date: 2026/05/21
Ge ZhangwenWu LiuxianWang ShuLi XukuiWang Tao - LIM-homeobox gene 2 (LHX2) participates in the progression of various tumors. However, its expression pattern, clinical significance, relationship with tumor microenvironment (TME), and biological function in clear cell renal cell carcinoma (ccRCC) remain unclear. - Source: PubMed
Publication date: 2026/03/21
Wang TengdaPeng QiangLi ShuaijieYang Liming - Cashmere goats produce high-value fine fibers derived from secondary hair follicles; however, the molecular mechanisms underlying this trait remain incompletely understood. In this study, comparative transcriptome sequencing was performed on skin tissues from Inner Mongolian cashmere goats and normal goats to characterize gene expression differences associated with cashmere fiber production. High-quality RNA-seq data with strong mapping efficiency and reproducibility were obtained across all samples. Differential expression analysis identified 1543 significantly differentially expressed genes (DEGs) between cashmere and normal goats, including genes involved in hair follicle morphogenesis, epidermal differentiation, cell proliferation, and extracellular matrix organization. Multivariate analyses showed a clear transcriptomic separation between fleece types, indicating that fleece phenotype is the primary driver of variation in global gene expression. Functional enrichment revealed significant involvement of the Wnt, MAPK, and PI3K-Akt signaling pathways, and several biologically relevant regulators of hair follicle development and hair cycle control, including , , , and , were differentially expressed. Gene fusion events were rare and showed no group specific patterns, whereas alternative splicing was widespread, with exon skipping as the predominant splicing event in goat skin. Overall, these results provide quantitative transcriptomic evidence linking signaling regulation, follicle development, and structural differentiation to secondary hair follicle activity and cashmere fiber formation, offering candidate genes and molecular pathways for functional validation and molecular breeding in cashmere goats. - Source: PubMed
Publication date: 2026/03/16
Riaz Hafiza AroobaKhan Muhammad IrfanZahra KiranAli RahmatJi Dejun - - Source: PubMed
Publication date: 2026/03/02
Skalski MarcinKowal-Wiśniewska EwelinaJaskiewicz-Rajewicz KatarzynaKiwerska KatarzynaBartochowska AnnaUstaszewski AdamGórecki TomaszMajchrzak-Celińska AleksandraWierzbicka MałgorzataJarmuż-Szymczak MałgorzataPaluszczak Jarosław