Ask about this productRelated genes to: ELF3 antibody
- Gene:
- ELF3 NIH gene
- Name:
- E74 like ETS transcription factor 3
- Previous symbol:
- ESX
- Synonyms:
- EPR-1, ESE-1, ERT
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-12
- Date modifiied:
- 2016-10-05
Related products to: ELF3 antibody
Related articles to: ELF3 antibody
- Thyroid cancer is the most prevalent endocrine malignancy, and papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Although the prognosis is generally favorable, a better understanding of the molecular mechanisms involved in this pathology could lead to new treatment opportunities. Dysregulation of miRNA expression has been correlated with tumor development, and miR-1179 has been previously identified as one of the most downregulated miRNAs in PTC. This study aimed to explore the role of miR-1179 in thyroid tumorigenesis. miR-1179 was overexpressed in the TPC-1, B-CPAP, and HTori-3 thyroid cell lines to characterize its function and identify mRNA targets. The relevance of our data for human PTC was then addressed by analyzing TCGA and independent PTC. We showed that miR-1179 triggered apoptosis and inhibited cell migration. We identified ELF3 as a direct target of miR-1179 and other effectors, including NOTCH3 and CX3CL1. Finally, we revealed the existence of an inverse correlation between decreased expression of miR-1179 and increased expression of , , and mRNA in human PTC. Our findings suggest that miR-1179 is a tumor suppressor gene and that its loss may contribute to thyroid tumor progression by promoting the expression of ELF3, NOTCH3, and CX3CL1. - Source: PubMed
Publication date: 2026/04/29
Henry NicolasBahassou NisrineLibert FrédérickDom GenevièveMaenhaut Carine - Pyroptosis promotes the progression of osteoarthritis (OA). This study aims to explore the functions and regulating mechanisms of E74-like factor 3 (ELF3) in chondrocyte pyroptosis. A mouse model of OA and lipopolysaccharide (LPS)-induced chondrocytes were employed. Adenovirus sh-ELF3, miR-9-5p inhibitor or oe-Nuclear Factor kappa B subunit 1 (NFKB1) were administered to OA mice via intra-articular injection. LPS-induced chondrocytes were transfected with sh-ELF3, oe-NFKB1, miR-9-5p mimic/inhibitor or negative controls. Articular cartilage tissues were assessed using H&E staining, Safranin O/fast green staining, and Osteoarthritis Research Society International (OARSI) grading system. Pyroptosis was assessed by flow cytometry combined with Western blot analysis of key markers, while apoptosis was detected by TUNEL staining. Levels of interleukin-1 beta (IL-1β) and Interleukin-18 (IL-18) were measured by enzyme linked immunosorbent assay (ELISA). Interactions among ELF3, miR-9-5p, and NFKB1 were validated using chromatin immunoprecipitation (ChIP) and luciferase reporter assays. We found that pyroptosis was enhanced and ELF3 expression was elevated in both the OA mouse model and LPS-induced chondrocytes. Depletion of ELF3 inhibited pyroptosis, apoptosis, extracellular matrix (ECM) degeneration, and inflammation in LPS-injured chondrocytes. Mechanistically, ELF3 suppressed miR-9-5p transcription, which targeted NFKB1, and NFKB1 interacted with ELF3 to form a regulatory loop. miR-9-5p inhibition or NFKB1 overexpression reversed the protective effects of ELF3 knockdown on pyroptosis and ECM degradation. In vivo study further confirmed that silencing ELF3 attenuated articular cartilage injury through miR-9-5p/NFKB1/ NLR Family Pyrin Domain Containing 3 (NLRP3) axis. Overall, the ELF3/miR-9-5p/NFKB1 axis accelerated OA progression by promoting NLRP3-mediated chondrocyte pyroptosis. - Source: PubMed
Publication date: 2026/05/01
Gong BinHe MengShen XiangWang SuiyuanTan Liming - Breast cancer is a molecularly heterogeneous disease composed of multiple intrinsic subtypes. Recent studies have highlighted the substantial intratumor heterogeneity of breast cancer, wherein malignant cells of distinct intrinsic subtypes co-exist within the same tumor. However, most existing subtyping methods are designed for bulk transcriptomic data and are therefore limited in their ability to resolve such intratumor heterogeneity at single-cell resolution. - Source: PubMed
Publication date: 2026/04/13
Li JingGao YuanZhang SiruiGuo ShouhuiHou QingzhenZhang ShisongYu WeixingLiu Ke - - Source: PubMed
Publication date: 2026/04/01
Wang MaomaoBo HaijiChen DapengMao JiangxinMiao ZongWang Laixing - Light and temperature are key environmental signals that regulate plant growth, development, and stress responses. To adapt to their fluctuating nature, plants employ epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs that reshape chromatin structure without altering DNA sequence. These processes convert transient environmental inputs into molecular memory, enabling rapid and reversible gene activation upon re-exposure. This review summarizes how photoreceptors (PHY, CRY, UVR8) and thermal sensors (H2A.Z, ELF3) coordinate with chromatin modifiers to regulate transcriptional states. Activating marks such as H3K4me3 and H3K27ac, along with poised RNA polymerase II, sustain transcriptional readiness, while demethylases and histone chaperones reset chromatin to restore stability after stress. Understanding this chromatin-based regulation provides a foundation for epigenetic crop improvement, offering new strategies to enhance plant resilience under increasing climatic variability. - Source: PubMed
Publication date: 2026/03/20
Alhammad Bushra AhmedZafar Muhammad MubasharAlasimi Shiah MSeleiman Mahmoud F