Ask about this productRelated genes to: TNFRSF21 antibody
- Gene:
- TNFRSF21 NIH gene
- Name:
- TNF receptor superfamily member 21
- Previous symbol:
- -
- Synonyms:
- DR6, CD358
- Chromosome:
- 6p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-27
- Date modifiied:
- 2016-10-05
Related products to: TNFRSF21 antibody
Related articles to: TNFRSF21 antibody
- Death receptor 6 (DR6), an orphan member of the tumor necrosis factor receptor superfamily, has been implicated in inflammation, autoimmunity, neurodegeneration, and cancer. Similar to other family members, its intracellular region, including caspase recruitment domain (CARD) and death domain (DD), mediates complex signaling networks by recruiting adaptor and downstream effectors. While studies have demonstrated that amyloid precursor protein (APP) binds to the extracellular domain of DR6, the conformational changes in its intracellular domains that initiate signaling remain unclear. In this study, we report the nearly complete backbone and sidechain resonance assignments of DR6-CARD, providing a foundation for studying the structural basis of DR6-mediated signaling pathways. - Source: PubMed
Publication date: 2026/07/11
Xia BiaoDuan YajingNing YuzheYuan WensuLin ZhiLi Zhen - Non-functioning pituitary adenoma (NFPA) is the most common pituitary tumor. Due to the lack of hormone hypersecretion, it is often diagnosed when the tumor enlarges and gives compression symptoms. Surgical resection is the primary treatment modality; however, complete remission rates remain suboptimal. In this study, we aimed to investigate differentially expressed genes (DEGs) that may be involved in NFPA pathogenesis. - Source: PubMed
Uzkul Nisa DevrimAkkoyunlu Deniz SunnetciCabuk BurakIsik Elif BusraIskenderoglu Elmas TunaKeskin Seda ErenCine NaciSavli Hakan - Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy with rising global incidence and mortality. Despite advances in immunotherapy and targeted therapies, treatment resistance remains a challenge, necessitating novel prognostic biomarkers and therapeutic strategies. Cuproptosis, a copper-dependent form of regulated cell death, and immune-related pathways have emerged as critical players in tumor progression. However, their combined prognostic potential in SKCM remains unexplored. Here, we constructed a cuproptosis-immune-related gene signature to predict SKCM prognosis and guide therapy. Using the TCGA database, we identified 474 cuproptosis-related immune genes through Pearson correlation analysis. By integrating the GTEx database, differential expression analysis revealed that 194 of these genes were significantly dysregulated in SKCM. Univariate Cox and LASSO regression analyses established a 12-gene prognostic model (C3AR1, CCL8, CCR1, CTLA4, HLA-DRB1, IFIH1, IL2RA, IRF9, KIR2DL4, TLR1, TNFRSF21, XCL2), stratifying patients into high- and low-risk groups. The model demonstrated robust predictive accuracy in training and validation cohorts. High-risk patients exhibited poorer survival, reduced immune infiltration, suppressed checkpoint expression, and lower tumor mutational burden (TMB), suggesting an immunosuppressive microenvironment. Conversely, low-risk patients showed enhanced immune infiltration, higher TMB, and increased checkpoint-related gene expression, suggesting an immune-inflamed but functionally restrained phenotype with potential relevance to immune checkpoint blockade. Drug sensitivity analysis revealed high-risk patients may benefit more from targeted therapies. A nomogram integrating risk scores and clinical factors further improved prognostic prediction, with calibration curves demonstrating strong concordance between predicted and observed survival probabilities. Single-cell RNA sequencing illustrated the cellular distribution of model genes, and functional experiments demonstrated that XCL2 suppresses melanoma cell proliferation, migration, and invasion. This study develops and validates a cuproptosis-immune integrated prognostic signature for SKCM, providing a framework to link cuproptosis-associated biology with immune microenvironmental features, risk stratification, and potential therapeutic decision-making. - Source: PubMed
Publication date: 2026/06/09
Zhao MeiruXiao MengZhang XinmeiZhang JunyanLiu TongWang Huiping - To develop a diagnostic model for osteosarcoma metastasis and elucidate the spatiotemporal role of necroptosis genes. - Source: PubMed
Publication date: 2026/05/30
Jiahao SunXu CuiRui GongWenpeng XieYongkui Zhang - Depression is a complex mental disorder that demands multi-target therapeutic strategies. The Radix Bupleuri-Radix Paeoniae Alba (CB) herb pair, a classic Traditional Chinese Medicine (TCM) formulation for "soothing the liver and relieving depression," shows clinical promise, yet its system-level mechanisms remain unclear. This study employed an integrated multi-omics approach, combining hippocampal metabolomics (UPLC/Q-TOF-MS), proteomics (TMT), and transcriptomics (RNA-seq), to elucidate the antidepressant mechanisms of CB in a chronic unpredictable mild stress (CUMS) rat model. Metabolomic analysis identified 10 differential hippocampal metabolites in depressed rats, among which CB significantly normalized five core biomarkers-creatine, xanthine, docosahexaenoic acid, arachidonic acid, and 3-O-sulfogalactosylceramide-implicating the restoration of arachidonic acid, purine, and glutathione metabolism. Integrated proteomic and transcriptomic analyses revealed that the core mechanisms involve the synergistic regulation of neuroinflammation and synaptic plasticity. CB downregulated pro-inflammatory mediators (e.g., NPTX2, TNFRSF21) while upregulating key modulators of neurotransmission (e.g., SLC6A2). Joint pathway analysis demonstrated concurrent suppression of neuroinflammatory signaling (e.g., NF-κB) and enhancement of synaptic remodeling pathways (e.g., PI3K/Akt/BDNF axis), alongside restoration of redox homeostasis (elevated GSH). This multi-omics study provides a systems-level understanding of the CB herb pair, demonstrating its coordinated action in suppressing neuroinflammation, enhancing synaptic plasticity, and rebalancing neuroendocrine and oxidative stress pathways. The findings bridge TCM theory with modern neurobiology, positioning CB as a synergistic, multi-target therapeutic candidate for depression. - Source: PubMed
Publication date: 2026/05/08
Zhang HongcaiLi XuanKuang HaixueWang QiuhongWang WenranZhang Shuxiang