Ask about this productRelated genes to: ZPLD1 antibody
- Gene:
- ZPLD1 NIH gene
- Name:
- zona pellucida like domain containing 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-06
- Date modifiied:
- 2016-07-05
Related products to: ZPLD1 antibody
Related articles to: ZPLD1 antibody
- Bladder cancer (BLCA) remains a leading urological malignancy with rising incidence and a dismal prognosis; therefore, reliable prognostic markers and actionable therapeutic targets are urgently needed. The extracellular-matrix-related gene Zona-Pellucida-like Domain-containing Protein 1 (ZPLD1) has not been investigated in BLCA. We therefore aimed to delineate the expression landscape, prognostic value, immune contexture, and druggability of ZPLD1 in BLCA. - Source: PubMed
Publication date: 2026/01/15
Chen YiwenZhu HanliangLao MeitingDing GuodongYue YouweiLi DongbingDeng Wangdong - Hypoxia, caused by reduced dissolved oxygen (DO) levels in water, is a critical challenge in aquaculture and often results in stress, anorexia, and mass mortality in fish. The olive flounder (Paralichthys olivaceus) is a key species in South Korea's global aquaculture exports. However, aquaculture production of P. olivaceus experiences significant economic losses caused by hypoxia-induced fish mortality, highlighting the critical need for developing genetically improved hypoxia-tolerant strains. In this study, a genome-wide association study (GWAS) was performed to unveil single-nucleotide polymorphisms (SNPs) associated with acute hypoxia tolerance and elucidate underlying regulatory mechanisms. A total of 382 P. olivaceus fish were measured for blood serum cortisol level using enzyme-linked immunosorbent assay (ELISA) upon acute hypoxia stress. Blood plasma cortisol levels were used as a proxy phenotype of hypoxia tolerance, with the hypothesis that elevated concentrations indicate low tolerance, and minimized concentrations indicate high tolerance to acute hypoxia stress. Then, fish were genotyped using the Affymetrix® Axiom® myDesign™ genotype array, and 57,651 SNPs were retained after quality control filtering. A significant SNP was identified on chromosome 15 of the P. olivaceus genome, above the suggestive threshold (p < 1 × 10) for the stress cortisol level trait. A strongly associated SNP with accession number AX-419149718 was located in the zona pellucida-like domain-containing protein 1 (Zpld1) gene. Gene ontology (GO) analysis suggests that Zpld1 is involved in signaling pathways, including the integrin-mediated signaling pathway, thereby contributing to the mitigation of hypoxia stress effects. Collectively, this study provides insights into the genetic basis of acute hypoxia tolerance in P. olivaceus and may serve as a foundation for establishing genomic selection of olive flounders with acute hypoxia stress tolerance in aquaculture breeding programs. - Source: PubMed
Publication date: 2025/12/11
Dilshan M A HKim GaeunOmeka W K MLiyanage D SUdayantha H M VRodrigo D C GGanepola G A N PHanchapola H A C RKodagoda Y KGong PoLee JihunLee SukkyoungKim JeongeunLee Jehee - In the fields of both vestibular and auditory research, reliable vestibular function tests are essential. However, unlike the auditory function tests, which use standard Auditory Brainstem Response (ABR) equipment, there is no equivalent widely adopted apparatus for vestibular tests. Vestibulo-ocular reflexes (VORs) are the compensatory ocular reflexes that ensure stable vision during head motion. VORs are widely used in clinics to diagnose vestibular deficits. In the research, VORs have been used by various groups to evaluate the mouse vestibular function. However, the effectiveness of VOR tests has not been systematically evaluated with appropriate mouse models, and the lack of commercial equipment hampers its accessibility, confining vestibular testing to a select few labs. - Source: PubMed
Publication date: 2025/08/29
Zhao TongXiao ShijieLiu WendaZhong JinhaoSun BinxianChen Fangyi - Vestibular research is essential for understanding and treating disorders such as vertigo and Meniere's disease. The vestibulo-ocular reflex (VOR) is a key method for assessing vestibular function and an essential tool for diagnosing vertigo. Traditionally, the VOR comprises angular VOR (aVOR) and translational VOR (tVOR), which originate from the vestibular semicircular canals (SCCs) and otolith organs, respectively. VOR consists of both fast-phase and slow-phase eye movements, which functionally interact to contribute to gaze control. However, to calculate the gain and phase parameters of the VOR, it is common practice to exclude fast-phase information superimposed on slow-phase eye movements. As a result, the information contained in the fast phase has not been fully utilized. OVAR is primarily used to evaluate otolith function, as there is no SCC input during its steady state. It is widely accepted that fast-phase nystagmus (FPN) during OVAR is generated by periodic otolith inputs via the central vestibular velocity storage mechanism. Surprisingly, we discovered in this study that SCC input can modify the generation of FPN in mouse OVAR test, as demonstrated by testing (Zona pellucida-like domain containing 1 protein) mutant mice with SCC deficits. This finding was further confirmed using both unilateral and bilateral semicircular canals dehiscence surgical models. In addition to revealing the dependence of FPN on SCC input, we demonstrated that FPN can be used to evaluate vestibular function, particularly in conditions that are difficult to assess using slow-phase eye movements, such as unilateral vestibular lesions and central modulation via baclofen treatment. - Source: PubMed
Publication date: 2025/03/07
Xiao ShijieZhao TongLiu WendaPeng ZihaoChen Fangyi - Pancreatic neuroendocrine tumors (PNETs) exhibit a wide range of behavior from localized disease to aggressive metastasis. A comprehensive transcriptomic profile capable of differentiating between these phenotypes remains elusive. - Source: PubMed
Greenberg Jacques AShah YajasIvanov Nikolay AMarshall TeaganKulm ScottWilliams JelaniTran CatherineScognamiglio TheresaHeymann Jonas JLee-Saxton Yeon JEgan CaitlinMajumdar SonaliMin Irene MZarnegar RasaHowe JamesKeutgen Xavier MFahey Thomas JElemento OlivierFinnerty Brendan M