Ask about this productRelated genes to: IZUMO1 antibody
- Gene:
- IZUMO1 NIH gene
- Name:
- izumo sperm-egg fusion 1
- Previous symbol:
- -
- Synonyms:
- IZUMO, MGC34799, OBF
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-01
- Date modifiied:
- 2014-07-23
Related products to: IZUMO1 antibody
Related articles to: IZUMO1 antibody
- Can human fertilization-competent spermatozoa be captured through their ability to bind the oocyte receptor JUNO? - Source: PubMed
Publication date: 2026/02/13
Cots-Rodríguez PaulaWang XinyinSanchez-Tudela MirianSiu Karen KYip PatrickGómez EmilioLee Jeffrey EHamze Julieta GJiménez-Movilla Maria - Temephos is a larvicide used in health campaigns against disease vectors, classified as slightly toxic. However, it has adverse effects on sperm function, the mechanisms of which are unknown. During fertilization, sperm are capacitated and proteins undergo tyrosine phosphorylation (p-Tyr), followed by actin cytoskeleton remodeling, which is important for the acrosome reaction (AR). Finally, IZUMO1 relocation during the AR is essential for gamete fusion. This study aimed to investigate the mechanism by which temephos decreases fertilization in male rats exposed to 10 or 100 mg/kg/day/5 days (WHO-NOAEL and LOAEL, respectively) and sacrificed 1-day after treatment. Sperm cells were collected from the cauda epididymis-vas deferens. No effects were observed with 10 mg/kg/day/5 days. However, at 100 mg/kg/day/5 days, the fertilization rate decreased (22%) and the chlortetracycline assay showed a decrease in Ca ionophore-induced AR (49%), suggesting that functional AR was impaired. This was confirmed by the decrease in p-Tyr and actin polymerization, which reduced IZUMO1 relocation. Furthermore, significant increases in protein serine and threonine phosphorylation (p-Ser and p-Thr) were observed, which may contribute to these effects. These results suggest that temephos exposure reduced the fertilization rate by decreasing sperm capacitation and actin polymerization, thereby affecting AR and IZUMO1 migration. - Source: PubMed
Publication date: 2026/03/04
Curbelo-Valiente AilemysRoa-Espitia Ana LilianMoreno-Bustamante Gabriela Mishellde Jesús Solís-Heredia MaríaTafoya-Domínguez DennisHernández-González Enrique OthónQuintanilla-Vega Betzabet - Sex differences in alcohol use behaviors are well-established: males typically engage in heavier and more frequent drinking and exhibit more externalizing behaviors (e.g., other substance use), while females often transition to dependence more rapidly and present more internalizing psychopathology (e.g., depression). The biological mechanisms underpinning these differences are relatively unknown. In this study, we investigated the sex-differentiated genetic architecture of 11 alcohol use phenotypes pertaining to frequency, quantity and problematic use by leveraging sex-stratified genome-wide association studies (Ns 40,335 to 613,148). Specifically, we compared SNP-based heritability ( ) estimates, individual genetic locus effects, genetic correlations ( ) across sexes, alcohol phenotypes and with comorbid traits from independent GWAS, and polygenic score () associations with medical outcomes from clinical populations. was broadly similar between sexes, except for higher estimates in males for and (). We identified four sex-differentiated top loci ( < 5 × 10), including a female-specific association in for and , and three male-specific associations in , and for and/or . Between-sex genetic correlations ranged from 0.68±0.07 to 0.89±0.04, these estimates were lowest for quantity measures and varied by beverage type, indicating partially distinct polygenic architecture. In males, we identified stronger positive genetic correlations with several externalizing traits (e.g., general addiction) compared to females. In females, we identified a specific positive genetic correlation with a single internalizing trait, self-harm. PGS analyses revealed sex-specific medical associations (e.g., bone/musculoskeletal conditions in females; hepatic/respiratory/infectious sequelae in males) that were obscured in sex-combined analyses; however, sex-specific PGS did not outperform combined-sex PGS for predicting alcohol use disorder diagnosis. Sex-aware analyses of alcohol use behaviors can improve our understanding of the genetic etiology of alcohol use and related health outcomes, and future studies should consider cultural variation (e.g., drinking attitudes, social norms) in the relationship between behavior and genetics. - Source: PubMed
Publication date: 2025/12/02
Vilar-Ribó LauraJennings Mariela VSallah AishaJinwala ZealThorpe Hayley HaBianchi Sevim BMeredith JohnFeuer KyraRader LydiaCourchesne-Krak NatasiaNiarchou MariaBalbona Jared Elson Sarah LFontanillas PierreJohnson Emma CDavis Lea KHatoum Alexander SMallard Travis TGustavson Daniel EZhou HangPalmer Abraham ASavage Jeanne EKember Rachel LSanchez-Roige Sandra - The binding of the sperm protein IZUMO1 to the oocyte receptor JUNO is an essential step in fertilization. Genetic deletion of IZUMO1 results in sterility, making this sperm protein a potential target for the development of an immunocontraceptive vaccine for the control of wildlife populations. However, contradictory results of the effect of immunization with IZUMO1 or IZUMO1-derived peptides have been reported. In this study, the effect of immunization with a recombinant mouse IZUMO1 peptide comprised of the extracellular Izumo, hairpin and Ig-like domains of IZUMO1 with different adjuvants was investigated in mice. The adjuvants were AddaS03, the nanoparticle adjuvant NanoST, composed of α-D-glucan nanoparticles and the STING agonist ADU-S100, or a combination of these two adjuvants. Immunization of outbred female mice induced a robust anti-IZUMO1 IgG response with significantly higher serum IgG2a titers in mice immunized with NanoST compared with AddaS03. Vaccines with NanoST alone or in combination with AddaS03 reduced the pregnancy rate and number of pups by more than 50 %, whereas vaccines formulated with AddaS03 alone had a limited effect. Infertility correlated with IgG directed against epitopes in the hairpin region of IZUMO1. These results support the further development of IZUMO1-based immunocontraceptive vaccines for wildlife population control. - Source: PubMed
Publication date: 2025/12/06
Hernandez-Franco Juan FAbdelkhalek AhmedZhang LijiaIbrahium Omnia MPerez Daniela CastilloFlora DelilahUpatising VarisraOstafe RalucaHogenEsch Harm - Genome-wide association studies (GWAS) have identified numerous genetic loci associated with COVID-19 susceptibility and severity. However, it remains unclear which variants specifically contribute to the progression from hospitalization to critical illness. To address this, we identified 394 symptom-differentiating SNPs (sdSNPs) by directly comparing GWAS summary statistics between critical and hospitalized COVID-19 cases. Among these, 13 were missense variants that may trigger phenotype conversion. To investigate their functional consequences, we performed structural modeling to evaluate the impact of these variants on protein stability. Eight proteins were predicted to be affected, including FUT2, ICAM5, IFNA10, PLSCR1, IZUMO1, ICAM1, RASIP1, and MICB, suggesting potential disruptions in immune signaling and host response pathways. Furthermore, Mendelian randomization analyses provided direct causal evidence: SMR analysis based on lung eQTL data demonstrated that higher FUT2 expression was significantly associated with increased risk of critical COVID-19 (β = 0.227, p = 2.69 × 10), compared to a weaker effect in hospitalized COVID-19 (β = 0.096, p = 3.97 × 10). In contrast, MR analysis using cis-pQTLs revealed that higher plasma levels of soluble ICAM5 (sICAM5) exerted protective effects, with stronger estimates in critical COVID-19 (β = -0.186, p = 5.54 × 10) than in hospitalized COVID-19 (β = -0.095, p = 1.69 × 10). These findings identify a distinct set of severity-specific genetic variants and offer mechanistic insights into how missense mutations may influence disease progression through structural and regulatory pathways. - Source: PubMed
Chen HongweiLi ZanHan XueZhang ShumiaoZhang HaoyangChen YongkunShu Yuelong