Ask about this productRelated genes to: DKKL1 antibody
- Gene:
- DKKL1 NIH gene
- Name:
- dickkopf like acrosomal protein 1
- Previous symbol:
- -
- Synonyms:
- SGY-1, CT34
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-09
- Date modifiied:
- 2016-10-05
Related products to: DKKL1 antibody
Related articles to: DKKL1 antibody
- Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large-scale proteogenomic integration and to evaluate their prediagnostic predictive value and effects on severity. - Source: PubMed
Publication date: 2026/05/22
Ding YuanHamitouche DylanThebault SimonKearns PatrickAbdelhak AhmedHarroud Adil - BACKGROUND: The testis exhibits the highest tissue-specific gene expression of all organs, including both coding and non-coding genes. Our previous study reported that Teshl, a testis-specific long noncoding RNA, associates with heat shock factor 2 (HSF2), a transcription factor, to regulate Y chromosome gene expression and sperm fertility. RESULTS: We conducted an in-depth analysis of the function and molecular mechanisms of Teshl using Teshl-knockout (KO) mice. Remarkably, the absence of Teshl caused abnormal acrosome biogenesis during spermiogenesis, resulting in malformed and disorganized acrosomes and abnormal sperm head morphology. Teshl-KO sperm also exhibited altered acrosome reaction and reduced motility. A thorough examination of all available relevant datasets identified three Teshl-related proteins associated with acrosome structure and function: actin related protein T1 (ACTRT1), acrosin binding protein (ACRBP) and dickkopf-like acrosomal protein 1 (DKKL1). Our findings suggest that these proteins are directly or indirectly regulated by Teshl-HSF2 through transcriptional or protein-interaction mechanisms. CONCLUSIONS: The present findings significantly expand our understanding of the important roles of Teshl, a pioneering testis-specific lncRNA, by elucidating its acrosomal function and mechanism in male reproduction. - Source: PubMed
Publication date: 2026/03/30
Hong Seung PyoHong Seong HyeonHan GwidongLee Seung JaeOh YoungsooCho Chunghee - Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignant neoplasm with an increasing need for precision therapeutics. Cancer-testis antigens (CTAs) represent promising targets given their aberrant tumor expression and otherwise localized expression to immune-privileged tissues with no (testis-restricted) or minimal (testis-selective) expression in other human body sites. Despite their potential, limited studies rigorously evaluate CTAs as therapeutic targets in HNSCC. - Source: PubMed
Memon Abdullah AAwan Musaddiq JEspinosa Oscar VillarrealKuehn RachelFrei AnneFoeckler JamieBruening JenniferAkakpo KennethMassey BeckyStadler MichaelWong StuartHimburg Heather AZenga Joseph - This study aimed to identify cytotoxic T lymphocyte (CTL)-specific epitopes from three tumor-associated antigens (TAAs)-Dickkopf-like 1 (DKKL1), F-box protein 39 (FBXO39), and Opa-interacting protein 5 (OIP5)-which are overexpressed in colorectal cancer (CRC), as potential candidates for CTL-mediated immunotherapy. - Source: PubMed
Publication date: 2025/06/17
Sun PeiweiWang LuolinLiu ZhongXu Zhenglei - The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic targets. - Source: PubMed
Publication date: 2025/06/04
Pan Zhen-KunWu Meng-HuaShi HuaNi Yong-JianGeng Quan-LiYe Jin-Sheng