Ask about this productRelated genes to: DKKL1 antibody
- Gene:
- DKKL1 NIH gene
- Name:
- dickkopf like acrosomal protein 1
- Previous symbol:
- -
- Synonyms:
- SGY-1, CT34
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-09
- Date modifiied:
- 2016-10-05
Related products to: DKKL1 antibody
Related articles to: DKKL1 antibody
- Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignant neoplasm with an increasing need for precision therapeutics. Cancer-testis antigens (CTAs) represent promising targets given their aberrant tumor expression and otherwise localized expression to immune-privileged tissues with no (testis-restricted) or minimal (testis-selective) expression in other human body sites. Despite their potential, limited studies rigorously evaluate CTAs as therapeutic targets in HNSCC. - Source: PubMed
Memon Abdullah AAwan Musaddiq JEspinosa Oscar VillarrealKuehn RachelFrei AnneFoeckler JamieBruening JenniferAkakpo KennethMassey BeckyStadler MichaelWong StuartHimburg Heather AZenga Joseph - This study aimed to identify cytotoxic T lymphocyte (CTL)-specific epitopes from three tumor-associated antigens (TAAs)-Dickkopf-like 1 (DKKL1), F-box protein 39 (FBXO39), and Opa-interacting protein 5 (OIP5)-which are overexpressed in colorectal cancer (CRC), as potential candidates for CTL-mediated immunotherapy. - Source: PubMed
Publication date: 2025/06/17
Sun PeiweiWang LuolinLiu ZhongXu Zhenglei - The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic targets. - Source: PubMed
Publication date: 2025/06/04
Pan Zhen-KunWu Meng-HuaShi HuaNi Yong-JianGeng Quan-LiYe Jin-Sheng - The DKK family is a canonical small family of WNT antagonists. Though recent studies have suggested that the DKK gene family may be involved in sex differentiation in , there are still a lot of things about the DKK gene family that we do not know. In this study, we used bioinformatics methods to identify members of the DKK gene family in and analyzed their phylogeny, covariance, gene structure, structural domains, promoter conserved sites, signal peptides, gonadal transcription factors, transcriptional profiles, and tissue expression profiles. Additionally, qRT-PCR results were utilized for the validation and preliminary investigation of the function of the DKK gene family in . The results showed that the DKK gene family is divided into six subfamilies, distributed on six different chromosomal scaffolds containing different gene structures and conserved motifs with the same structural domains, and all of the members were secreted proteins. Our transcriptional profiling and embryonic expression analysis showed that and were significantly expressed in the testes, whereas and were significantly upregulated in the ovaries. This suggests a potential function in sex differentiation in . Our results may provide a basic theoretical basis for the sex differentiation process in . - Source: PubMed
Publication date: 2024/03/18
Wang YongchangZhu JunxianChen ChenJi LiqinHong XiaoyouLiu XiaoliChen HaigangWei ChengqingZhang JunjieZhu XinpingLi Wei - Endometrial polyps (EPs) are benign overgrowths of the endometrial tissue lining the uterus, often causing abnormal bleeding or infertility. This study analyzed gene expression differences between EPs and adjacent endometrial tissue to elucidate intrinsic abnormalities promoting pathological overgrowth. RNA sequencing of 12 pairs of EPs and the surrounding endometrial tissue from infertile women revealed 322 differentially expressed genes. Protein-protein interaction network analysis revealed significant alterations in specific signaling pathways, notably Wnt signaling and vascular smooth muscle regulation, suggesting these pathways play critical roles in the pathophysiology of EPs. Wnt-related genes and were upregulated, while , , , , and were downregulated. Relevant genes for vascular smooth muscle contraction were nearly all downregulated in EPs, including , , , , , , and . Overall, the results indicate fundamental gene expression changes promote EP formation through unrestrained growth signaling and vascular defects. The intrinsic signaling abnormalities likely contribute to clinical symptoms of abnormal uterine bleeding and infertility common in EP patients. This analysis provides molecular insights into abnormal endometrial overgrowth to guide improved diagnostic and therapeutic approaches for this troublesome women's health condition. Confirmation of expanded cohorts and further investigations into implicated regulatory relationships are warranted. - Source: PubMed
Publication date: 2024/02/22
Chiu Christine Shan-ChiYeh Ling-YuPan Szu-HuaLi Sheng-Hsiang