Ask about this productRelated genes to: GALNT13 antibody
- Gene:
- GALNT13 NIH gene
- Name:
- polypeptide N-acetylgalactosaminyltransferase 13
- Previous symbol:
- -
- Synonyms:
- KIAA1918, GalNAc-T13
- Chromosome:
- 2q23.3-q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-02
- Date modifiied:
- 2018-02-13
Related products to: GALNT13 antibody
Related articles to: GALNT13 antibody
- Genetic risk factors for Parkinson's disease (PD) remain under-characterized in East Asian populations. We assembled a Taiwanese case-control cohort (2245 PD; 2147 controls), genotyped participants using the Illumina NeuroBooster Array, and imputed 7.6 million variants with the Taiwan Biobank reference panel. Logistic-regression GWAS identified genome-wide significant associations at SNCA and MCCC1, with the lead SNCA signal located in intron 4; conditional and joint analyses suggested an additional 5' SNCA component. We observed suggestive associations at GCH1, PPARGC1A, and GALNT13. Locus-focused haplotype analyses refined the SNCA signal, delineating an East Asian-enriched risk haplotype, and confirmed risk effects of LRRK2 p.G2385R and p.R1628P, including evidence consistent with a gene-dosage effect. A European-derived PRS showed modest discrimination in our cohort (AUC 0.59), while incorporating East Asian and Taiwan-relevant variants improved performance (AUC 0.62). Together, these results define the genetic architecture of PD in Taiwan, highlight shared and population-enriched risk components, and support ancestry-aware PRS construction for improved risk stratification. - Source: PubMed
Publication date: 2026/05/22
Chu Yung-TsaiSu Yu-AnLin Chin-HsienTai Chun-HweiWu Yih-RuHong Chien-TaiChen Yu-WeiTsai Mong-HsunHardy JohnMok Kin-YingWu Ruey-Meei - Glycosylation, a key and prevalent modification in brain proteins and lipids, is essential for brain development and function. O-GalNAc glycosylation, initiated by the family of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts, s), is the most abundant type of O-glycosylation in the brain. Despite growing evidence linking variations to neuropsychiatric disorders, the molecular roles and underlying mechanisms by which O-GalNAc glycosylation contributes to brain functions remain poorly characterized. Here, we focus on GalNAc-T13, a member of the GalNAc-T family that is highly expressed in the brain. We established a brain-specific conditional knockout mouse model and found that these mice exhibited reduced neurite length, simplified dendritic branching, and decreased dendritic spine density in the cerebral cortex across embryonic and adult stages. Behavioral analyses further revealed impaired spatial memory consolidation following knockout. Mechanistically, we identified seizure protein 6 (SEZ6), a neurodevelopment-related protein, as a key substrate of GalNAc-T13 using a lectin-based mass spectrometry glycoproteomic approach. Our results demonstrated that GalNAc-T13 regulates the O-GalNAc glycosylation levels of SEZ6 with high catalytic efficiency in vitro and in vivo, improving protein stability and its interaction with PRSS12 at the cell surface to promote neurite outgrowth. Collectively, these findings suggest a critical role for GalNAc-T13 in maintaining cortical neurite architecture and memory retention, providing a mechanistic example for understanding the function of O-GalNAc glycosylation in the brain. - Source: PubMed
Publication date: 2026/03/06
Deng YaoZou XiaZhang HanLu XiaoyanZhao XingmingJia WenjuanXu YingjiaoYang FangNarimatsu HisashiZhang Yan - A complete telomere-to-telomere (T2T) genome is essential for advancing pig genomic research. Here we assembled a pig T2T gap-free genome T2T-pig1.0 (2.63 Gb) for a boar in Wuzhishan, China, covering all 20 chromosomes. T2T-pig1.0 with an accuracy of >99.999% uncovers 194.42 Mb of previously unresolved regions (PURs), and 1,189 new genes are added to the current reference genome Sscrofa11.1. We annotated 111 protein-coding genes with 11 male-specific conserved orthologous genes on chromosome Y (43.25 Mb). Pig-specific centromeric satellite repeat units are revealed. Centromeric regions of all telocentric chromosomes harbor a unique structure, 'telomere-SAT1B-(mSAT)ₙ-SAT3-q_arm', and a few young long terminal repeats. With the addition of 339,092 single-nucleotide polymorphisms in PURs, the population structure is updated with cross-continental introgression, and a selective sweep analysis reveals 280 new regions and 133 new genes potentially associated with body stature. GALNT13, with strong selection signals, has a role in inhibiting porcine chondrocyte proliferation while promoting chondrocyte differentiation. - Source: PubMed
Publication date: 2025/12/12
Luo Ya-BiaoHuang NingZha Cheng-WanYang Li-XianXue Peng-XiangXu QiaoYang Xiao-YangZhang Long-MiaoWang Yu-BeiChao ZheSun Rui-PingWang FengJia Shan-GangFang Mei-Ying - Pleomorphic adenoma (PA), the most common benign salivary gland tumor, harbors unpredictable risks of recurrence and malignant transformation into carcinoma ex pleomorphic adenoma (CXPA), posing significant clinical challenges. To better delineate the tumor transformation trajectory, we performed single-cell RNA sequencing of normal salivary gland, primary PA, recurrent PA (rPA), and CXPA. Cell trajectory reconstruction, differential expression gene identification, and key gene network analysis were integrated to characterize molecular transitions and intercellular crosstalk driving PA recurrence and malignant transformation. Immunohistochemistry was used to validate key findings. GALNT13 + myoepithelial cells were identified as CXPA-specific malignant progenitors, delineating early malignant conversion. Concurrently, MIF + myoepithelial cells exhibited enhanced tissue-destructive capabilities. Fibroblasts enforced fibrotic restraint in primary PA and drove extracellular matrix degradation in CXPA. The tumor microenvironment exhibited stage-specific adaptations, with CXPA favoring pro-inflammatory MIF-CD74/CD44 signaling and rPA adopting immunosuppressive traits. Stromal reprogramming and immune-editing dynamics collectively orchestrated microenvironmental adaptation, linking cellular heterogeneity to clinical aggressiveness. This study provides the first comprehensive molecular atlas of PA-to-CXPA transformation, revealing malignant specialization of the myoepithelial subpopulation, fibroblast-mediated stromal reprogramming, and immune-editing driven microenvironmental adaptation. These findings provide a framework for precision stratification of the malignant potential of PA, while positioning microenvironmental intervention as a cornerstone of future clinical strategies. - Source: PubMed
Publication date: 2025/10/14
Li YikeLi ZhixuanZhao GuileHan QiDing ZhangfanWang ChengLi Chunjie - : Previous multi-ethnic genome-wide association studies (GWAS) have identified the GALNT13 rs10196189 polymorphism as a potential genetic marker linked to sprint-power performance. However, its relevance in East Asian populations, particularly the Han Chinese, remains untested. This study aimed to replicate the association of rs10196189 with elite sprint-power athlete status in Han Chinese males and examine its potential influence on physical performance traits and tissue-specific gene regulation. : A total of 188 healthy Han Chinese males (49 elite sprint-power athletes and 139 non-athletic controls) were genotyped using the TaqMan assay. Assessments included strength, sprint, jump, anaerobic power, DXA-derived body composition, and muscle ultrasound. Logistic regression and ROC analyses evaluated the predictive value of rs10196189. Linear regression models adjusted for age and BMI tested genotype-phenotype associations. Tissue expression and functional networks were analyzed using GTEx and HumanBase databases. : The G allele frequency was significantly higher in athletes (12.2%) than in controls (5.4%, = 0.042). Dominant and additive models effectively predicted athlete status (OR = 2.53-2.58, < 0.05). Although most traits showed no significant associations post-correction, medial gastrocnemius thickness showed a nominal association (β = 0.371, = 0.011). Functional analyses revealed high GALNT13 expression in brain tissue and co-expression networks enriched in synaptic signaling and glycosylation pathways. : This is the first study to validate the association of GALNT13 rs10196189 with elite athletic status in Han Chinese males. Findings provide novel population-specific evidence and propose tissue-specific glycosylation and neural mechanisms as pathways linking this variant to sprint-power phenotypes. - Source: PubMed
Publication date: 2025/08/20
Chen LunWang MingruiLiu LongtianjiaoJiang XiaoyuCao ZihangAzhati SamuhaerChen HangyuShe KaixinZhu JinyaoChen MingLi JindaKong JunhaoZhang JiahaoYan YuangDong YiMieryazi ApudumalikeLiu SongyuZhang YanyanMa YixuanShi Lijun