Ask about this productRelated genes to: LRRTM4 antibody
- Gene:
- LRRTM4 NIH gene
- Name:
- leucine rich repeat transmembrane neuronal 4
- Previous symbol:
- -
- Synonyms:
- FLJ12568
- Chromosome:
- 2p12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-22
- Date modifiied:
- 2014-11-18
Related products to: LRRTM4 antibody
Related articles to: LRRTM4 antibody
- Sarcopenia lacks causal mechanisms and translatable targets. We integrated virtual gene knockout with multi-omics (n = 238 biopsies, 5 GEO cohorts) and single-cell RNA-seq (n = 10, 12,847 cells) to identify fibroblast-specific drivers. After ComBat batch correction, WGCNA identified a red module (690 genes, r = 0.74, P < 0.001) intersecting with 304 differentially expressed genes (|logFC|>0.585, FDR<0.05), yielding 163 candidates. scTenifoldKnk virtual gene knockout ranked PXDNL as the top fibroblast-specific driver (perturbation score = 2.34, CV<15%), perturbing 327 ECM genes (e.g., FBN1 ΔE = +0.82, LRRTM4 ΔE = -0.71). A 12-gene panel (including PXDNL) was derived from 113 ML algorithm benchmark (plsRglm optimal: training AUROC = 0.938, external validation AUROC = 0.804, 95%CI:0.636-0.938). Drug repurposing (DSigDB, Z > 2.0) identified GABA as the top candidate. Molecular docking revealed strong PXDNL-GABA binding (ΔG = -5.6 kcal/mol) at the peroxidase domain, which was further validated by enzymatic activity assays. In dexamethasone-induced and TNF-α induced atrophy models of CC or HMCs, 50 μM GABA restored cell viability (P < 0.001), downregulated Atrogin-1 (FBXO32)/MuRF-1 (TRIM63) (P < 0.01), and reversed PXDNL overexpression effects. This study establishes the fibroblast-PXDNL-ECM axis as a causal mechanism in sarcopenia and validates GABA as a repurposable therapeutic, providing a complete in silico-to-in vitro framework for age-related muscle disease. - Source: PubMed
Publication date: 2026/04/16
Cui Wei - - Source: PubMed
Publication date: 2026/02/19
Zhang JingjieMeng XianmeiZhou YiJiang ZhengyuChen HongsuoMeng ZhiyiZhang QiChen Weichang - In humans, disruptions in social behaviour are characteristic of many neuropsychiatric disorders, where both genetic risk factors and synaptic dysfunctions can contribute to the phenotype. Among the genes implicated in synaptic regulation, the synaptic adhesion protein leucine-rich repeat transmembrane protein 4 (LRRTM4) has been identified as a key player in maintaining synaptic function and neuronal circuit integrity. However, the potential involvement of LRRTM4 in modulating social behaviour and its contribution to social deficits has yet to be explored. - Source: PubMed
Publication date: 2025/12/26
Hillman CourtneyPetracco GiuliaFontana Barbara DScaia María FlorenciaDalla-Vecchia ElisaWetton Jon HNorton William H JParker Matthew OReichmann Florian - Methotrexate (MTX) is a widely used chemotherapy drug, but its neurotoxicity can lead to cognitive impairments, particularly through effects on hippocampal function. Nevertheless, the underlying molecular mechanisms are not fully understood. Deciphering MTX-induced cognitive impairment-linked molecular mechanisms in cells of the hippocampus could uncover novel therapeutic targets. - Source: PubMed
Publication date: 2025/09/23
Ye JishiDing YuWu RuolanDing HuangRen JuanXia ZhongyuanChen JingliXie ShuangJia Yifan - Recent multiomics advancements have improved our understanding of immune dysregulation in dilated cardiomyopathy (DCM). However, specific immune cell subsets and their regulatory genes are still ambiguous. This study aimed to explore immune cell imbalances and regulatory genes in DCM, discover diagnostic biomarkers, and identify potential therapeutic targets. Immune cell infiltration in DCM patients was quantified via deconvolution algorithms and single-cell RNA sequencing. Flow cytometry validation in 40 DCM patients and 40 healthy controls confirmed a notable increase in CD4 effector memory T cells (CD4 TEM cells) in DCM patients. Differential expression analysis of the GSE101585 dataset revealed 1783 genes. Weighted gene coexpression network analysis (WGCNA) identified a core immune-regulatory gene set, and protein-protein interaction (PPI) analysis highlighted 36 hub genes. Machine learning cross-validation identified four diagnostic biomarkers (, , , and ) whose transcriptional changes had been validated by qPCR. Among these genes, was strongly correlated with CD4 TEM cell abundance. Additionally, DSigDB analysis predicted 87 potential therapeutic drugs, with being the target of the most drugs. This study reveals a CD4 T cell subset-centered immunoregulatory network in DCM, identifying novel diagnostic biomarkers and druggable targets to guide precision immunomodulatory strategies for DCM management. - Source: PubMed
Publication date: 2025/08/13
Zhang XinyuZhou JuntengKang YuChen XiaojingYang ZixuanXie YingjingLiu TingLiu XiaojingZhang Qing