Ask about this productRelated genes to: UGT2A3 antibody
- Gene:
- UGT2A3 NIH gene
- Name:
- UDP glucuronosyltransferase family 2 member A3
- Previous symbol:
- -
- Synonyms:
- FLJ21934
- Chromosome:
- 4q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-20
- Date modifiied:
- 2016-03-01
Related products to: UGT2A3 antibody
Related articles to: UGT2A3 antibody
- Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a genome-wide association study (GWAS) to investigate genetic predictors of risperidone response in pediatric patients (n = 161) who received inpatient care at a pediatric hospital in a rural setting. Clinical, demographic, and treatment outcomes data, collected retrospectively, were incorporated into predictive models. While 41.0% of patients discontinued risperidone, patients remained on risperidone longer than other antipsychotics, with the exception of quetiapine. Female patients discontinued more quickly, as did patients in the acute program compared to residential. We identified nine genetic variants associated with risperidone outcomes: duration of risperidone treatment and frequency of risperidone discontinuation (rs10270303, intronic variant, PTPRN2), maximum risperidone dose (rs6014649, intergenic variant between CBLN4 and MC3R; rs56261530, synonymous variant, SHD), time to readmission (rs35722167, intergenic variant between UGT2A3 and UGT2B7; rs62382382, intronic variant, SGCD; rs62466698, intergenic variant between BET1 and GNG11; rs1152938, intronic variant, CPM), and duration of hospital stay (rs117426990, 3'-UTR variant, TMX3; rs5956073, intergenic variant between DOCK11 and LINC01285). Our study is the first GWAS of risperidone response in pediatric populations, which provides insights into the biological complexity of risperidone response, as well as moving toward precision antipsychotic treatment. Our study demonstrates the high value of conducting research in a community-based setting and highlights the need to expand research studies beyond academic medical centers. - Source: PubMed
Publication date: 2026/04/14
Staples Jack WKillam Shayna RBrown Karen EDalton RachelSather ElizabethChen QiangLoveland JoshuaSchwanke CorbinElias Abdallah FBigos Kristin LWoodahl Erica L - Colorectal cancer (CRC) is the primary driver of cancer-related death and illness across the world. Despite the full-scale shift of the treatment approach for some colorectal cancer patients due to the use of immune checkpoint inhibitors (ICIs), primary resistance still poses a huge challenge to clinicians. Bile acid metabolism is involved in the pathogenesis of CRC. However, its particular function in shaping the tumor immune microenvironment (TIME) and its effect on prognosis and immune treatment response remain unclear. - Source: PubMed
Publication date: 2026/01/12
Feng LiWang MinLi XinWu LongGu DeXinZhang BinZheng PengYang QifengWang KeMao Gang - To investigate the changes in hepatic phase II detoxification enzymes and their mechanism in metabolic associated steatohepatitis (MASH) induced by a methionine-choline-deficient (MCD) diet in mice. Ten C57BL/6J mice were randomly divided into two groups, with five mice in each group, and fed with a control diet (NCD group) and a methionine-choline-deficient diet (MCD group) for four consecutive weeks to establish the MASH model in mice. Mice body weight was recorded weekly. Mice peripheral blood and liver tissue samples were collected after four weeks. The liver histopathological changes were observed by hematoxylin-eosin staining and Sirius red staining in liver tissue. The levels of plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglycerides were measured by an automatic biochemical analyzer. Triglyceride and total cholesterol were used to evaluate the lipid accumulation condition in the liver of mice with Oil red O staining. Real-time fluorescence quantitative PCR was used to detect the expression of liver inflammatory factors interleukin (IL)-1β and monocyte chemoattractant protein-1 (MCP-1) condition. Transcriptome sequencing and bioinformatics were used to analyze the changes in gene expression profiles in the liver of mice and screen differentially expressed genes. The expression conditions of phase Ⅱ detoxification enzymes glutathione S-transferase mu 4 (GSTM4), dihydronicotinamide riboside:quinone oxidoreductases (NQO-2), sulfotransferase 1β1 (SULT1β1), and uridine diphosphate glucuronosyltransferase 2 family, polypeptide A3(UGT2A3) were verified by real-time fluorescent quantitative PCR. Plasma malondialdehyde content, total antioxidant capacity (T-AOC), plasma and liver glutathione content were determined using commercial kits. The expression of nuclear factor E2-related factor 2 (Nrf2), GSTM4, and UGT1A6 was examined by Western blotting. The independent sample -test was used for comparison between the groups. The body weight of mice in the MCD group showed a gradual downward trend, while the body weight of mice in the NCD group did not change significantly following four weeks of different dietary feeding. The MCD group mice liver had yellow-white appearance with round edges. The liver/body mass index was significantly lower in the NCD group (=3.216, <0.01). Hematoxylin-eosin staining showed that hepatocytes in the MCD group had an occurrence of fatty degeneration accompanied by inflammatory cell infiltration, with a higher NAFLD activity score (NAS) compared to the NCD group (=7.155, <0.001). Sirius red staining showed that the the liver of the MCD group had mildly increased periportal fibers. Plasma biochemical tests indicated that plasma ALT, AST, and triglyceride levels were significantly higher in the MCD group than those in the NCD group (=8.920, <0.001; =6.696, <0.001; =3.904, <0.01). Oil red O staining showed that a large number of lipid droplets accumulated in the liver tissue of the MCD group and were more severe than those in the NCD group (=7.405, <0.001). The triglyceride content was significantly higher in the liver of the mice in the MCD group than that in the NCD group (=3.559, <0.01), and the expression of inflammatory factors IL-1β and MCP-1 was significantly increased (=2.562 and 2.391, respectively, <0.05). Transcriptome sequencing analysis showed that the expression profile of genes related to lipid metabolism was changed in the liver tissue of the mice in the MCD group. The expression of multiple phase Ⅱ detoxification enzymes was significantly downregulated. Real-time fluorescence quantitative PCR verification demonstrated that the expression of four phase Ⅱ detoxification enzymes GSTM4, NQO2, SUIL1β1, and UGT2A3 were significantly lower in the liver of the mice in the MCD group than those in the NCD group (=2.498, 3.570, 3.768, and 4.166, respectively, <0.05). The detection kit showed that compared with the NCD group, the malondialdehyde content in the liver of mice in the MCD group increased (=3.601, <0.01), while the plasma total glutathione (=11.93, <0.001) and reduced glutathione levels were significantly reduced (=3.635, <0.01). The total antioxidant capacity of the liver decreased (=2.872, <0.05), and the total glutathione and reduced glutathione levels in the liver were significantly increased (=3.175 and 3.064, <0.05). Western blotting showed that the expression of Nrf2, GSTM4, and UGT1A6 proteins was significantly lower in the MCD group than that in the NCD group (=3.385, 2.990, 2.168, <0.05). The expressions of multiple phase Ⅱ detoxification enzymes and antioxidant capacity are reduced in the liver of MASH mice induced by the MCD diet, and its mechanism is related to the down-regulation of the expression of the upstream regulatory factor Nrf2 protein. - Source: PubMed
Gao J QZuo BPi C QXiao MWang J XTao W JHe Y - This study determined novel metabolism-related diagnostic biomarkers for ulcer-ative colitis (UC) and assessed their correlation with immune cell infiltration levels. Transcriptome data of UC was downloaded from the Gene Expression Omnibus (GEO) database, metabolism-related genes were summarised from the Gene Set Enrichment Analysis (GSEA) database. A total of 537 metabolism-related differen-tially expressed genes (DEGs) in UC were applied to functional enrichment analy-sis. We processed least absolute shrinkage and selection operator (LASSO) regres-sion analysis and support vector machine-recursive feature elimination (SVM-RFE). We obtained 6 potential metabolism-related diagnostic biomarkers (CHST13, ETNK1, LPCAT1, PDE6A, PLA2G2A, and UGT2A3). Expression patterns and diagnostic ROC curves were depicted in both the training and testing co-horts to verify their diagnostic value. Immune infiltration analysis indicated that UC samples have more abundant infiltration levels of immune cells. Fur-thermore, the upregulated diagnostic biomarkers significantly positively cor-related with B cell memory, T cell CD4 memory activated, dendritic cells ac-tivated, etc., while the downregulated ones mainly significantly positively correlated with mast cells resting, NK cells activated, and macrophages M2. Our study primarily identified 6 metabolism regulators (CHST13, ETNK1, LP-CAT1, PDE6A, PLA2G2A, and UGT2A3) as potential diagnostic biomarkers for UC and determined their correlation with immune infiltration. - Source: PubMed
Duan QilongLiu PengChen HualeiDing YuanyuanXu Xiaoming - Inflammatory bowel disease (IBD) presents unpredictable therapeutic responses and complex immune dysregulation. Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance. - Source: PubMed
Publication date: 2025/07/31
Wang MingmingLiang LipingTang ZiboHan JiminWu LeleLiu LeChen Ye