Ask about this productRelated genes to: DNAJC1 antibody
- Gene:
- DNAJC1 NIH gene
- Name:
- DnaJ heat shock protein family (Hsp40) member C1
- Previous symbol:
- -
- Synonyms:
- DNAJL1, ERdj1, MTJ1
- Chromosome:
- 10p12.31
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-17
- Date modifiied:
- 2016-10-05
Related products to: DNAJC1 antibody
Related articles to: DNAJC1 antibody
- The Karan Fries (KF), a newly developed dairy cattle (Holstein Friesian × Tharparkar), after nine generations of inter se mating (mating among crossbreds) by maintaining a stable, composite breed structure, is expected to preserve some heterosis or hybrid vigour through the retention of heterozygosity and selective pressure for performance traits. Although a decline in productivity is generally seen from F1 to later inter se generations, the rate of loss of heterosis slows down, allowing the population to reach a new equilibrium. This seems to be an interesting proposition. Therefore, to assess the retained heterosis and to evaluate the current status of the KF population, the present study was conducted, which included a sizeable phenotyped and genotyped animals (n = 355). The analysis identified a stabilized genomic architecture with a mean exotic inheritance of 64.34 ± 0.74% (predominantly Holstein Friesian) and an indigenous contribution of 35.66 ± 0.95% (primarily Tharparkar). Genomic indicators of heterosis revealed a mean Genomic Retained Heterosis (RH) of 59% which accounts for 15.82% of the total observed KF average yield (4153.14 ± 167.32 kg). Genomic Retained Heterozygosity (RHET) of 0.44%. Notably, a near-perfect correlation (r = 0.98) was observed between these two metrics, indicating that RHET can be used interchangeably with RH to assess heterosis and its effects in instances where parental genotypic records were absent. Linear regression analysis demonstrated that RH was a primary driver of productivity, with Total Milk Yield (TMY) increasing by 1113.81 ± 301.91 kg per unit increase in RH (p < 0.001). The impact on TMY was significantly larger than on 305-day milk yield (339.08 ± 282.92 kg), suggesting that genomic heterosis specifically enhances lactation persistence and environmental robustness. A joint-model GWAS identified 182 SNPs with significant additive effects and 117 SNPs with significant dominance effects for TMY. Functional annotation revels candidate genes for milk synthesis (SLC25A1, PIP4K2A, LATS2), heat stress resilience (DNAJB5, DNAJC1), and immunological defence (ARHGAP15, LPAR3). Protein network analysis identified the Mitochondrial Ribosomal Protein (MRP) family, specifically hub gene MRPL22, as the central driving gene for both additive and dominance components. These findings confirm that KF cattle effectively leverage retained heterosis to integrate high production potential with robust tropical climatic adaptability. - Source: PubMed
Publication date: 2026/07/20
Kumar IshmeetVyas JayeshKhan AsadRamola GargiIlayaraja IMuansangi LalChitra AnilPal PritamSingh Ritik KumarKamboj M LRaja T VMukherjee AnupamaMukherjee Sabyasachi - Recent studies suggested that genetic mutations in the DNAJC family might elevate the risk of Parkinson's disease (PD). Nevertheless, the role of some DNAJC genes in PD remains controversial, and previous studies lacked downstream research. In this study, we aim to explore the relationship between DNAJC family genes and PD in a European cohort through a comprehensive method. - Source: PubMed
Publication date: 2026/04/09
Yang DehaoXu JingxuanZhu YushengLu YangguangYao RuotongYe ZihanYu BohuaiChen JiaxuanZhang TingxuanLiu BowenHuang SuwenChen Guangyong - Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia and other symptoms, which pose significant challenges to individual health, life expectancy, and public healthcare systems. The escalating global prevalence of diabetes underscores the need for innovative therapeutic interventions. In this article, we critically comment on the study by Wang , published in the , which elucidates the therapeutic potential of Plantamajoside (PMS) in type 2 DM (T2DM) management. The authors provide evidence for the mechanism of action of PMS in T2DM models, demonstrating prevention of endoplasmic reticulum stress and apoptosis of pancreatic β-cells activation of DNAJC1. This manuscript provides a brief review of the pathogenesis of T2DM, explores the various roles of PMS in disease therapy in addition to the DNAJC-related apoptotic and autophagic functions, critically evaluates the experimental approaches employed by Wang , and provides recommendations for advancing future research. - Source: PubMed
Al-Bari Md Abdul AlimDavamani FabianBhatnagar PayalEid Nabil - Plantamajoside (PMS) has shown potential in mitigating cell damage caused by high glucose (HG) levels. Despite this, the precise therapeutic effects of PMS on type 2 diabetes mellitus (T2DM) and the underlying regulatory mechanisms require further exploration. - Source: PubMed
Wang DuoWang Yuan-SongZhao Hong-MinLu PengLi MengLi WeiCui Huan-TianZhang Zhong-YongLv Shu-Quan - Exploring the genetic landscape of native cattle is an exciting avenue for elucidating nuanced patterns of genetic variation and adaptive dynamics. Xiangnan cattle, a native Chinese cattle breed mainly produced in Hunan Province, are well adapted to the high temperature and humidity of the local environment and exhibit strong disease resistance. Herein, we employed whole-genome sequences of 16 Xiangnan cattle complemented by published genome data from 81 cattle. Our findings revealed that Xiangnan cattle are pure East Asian indicine cattle with high genetic diversity and low inbreeding. By annotating the selection signals obtained by the CLR, π, , and XP-EHH methods, genes associated with immunity (, , , and ) and heat tolerance (, , , , and ) were identified. In addition, the considerable introgression from banteng and gaur also contributed to the rapid adaptation of Xiangnan cattle to the environment of Southern China. These results will provide a basis for the further conservation and exploitation of Xiangnan cattle genetic resources. - Source: PubMed
Publication date: 2024/12/01
Yan HuixuanLi JianboZhang KunyuDuan HongfengSun AoZhang BaizhongLi FuqiangChen NingboLei ChuzhaoYi Kangle