Ask about this productRelated genes to: SDF4 antibody
- Gene:
- SDF4 NIH gene
- Name:
- stromal cell derived factor 4
- Previous symbol:
- -
- Synonyms:
- Cab45
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-24
- Date modifiied:
- 2014-11-19
Related products to: SDF4 antibody
Related articles to: SDF4 antibody
- : Various pathophysiological mechanisms play a role in the development of cardiovascular diseases (CVDs). There is a need for new biomarkers that can complement existing clinical findings, particularly in the early diagnosis and prognostic assessment of coronary artery disease (CAD) and that can also contribute to more effective management of the diagnosis and treatment process. Therefore, both blood and pericardial fluid samples can provide important diagnostic information. This study aims to investigate Stromal Cell-Derived Factor 4 (SDF4) levels and thiol/disulfide homeostasis in the blood and pericardial fluid of patients with established CAD undergoing open-heart surgery with cardiopulmonary bypass (CPB), in order to better characterize oxidative stress-related and redox-mediated pathophysiological processes associated with the development and progression of coronary heart disease. Comparisons with a healthy control group were performed to elucidate disease-related biochemical alterations rather than to propose these markers as diagnostic tools for CAD. : In this study, intraoperatively collected venous blood and pericardial fluid samples from 45 patients undergoing on-pump coronary artery bypass grafting were analyzed. SDF4 levels were measured using enzyme-linked immunosorbent assay (ELISA), while thiol-disulfide homeostasis was assessed via spectrophotometric analysis. : The study revealed statistically significant differences in parameters such as SDF-4, native thiol, total thiol, disulfide, and disulfide/total thiol ratio among the control, patient serum, and pericardial fluid groups ( < 0.05). Notably, SDF-4 and disulfide levels were elevated, while thiol levels were reduced in the pericardial fluid group, suggesting increased oxidative stress and disrupted redox balance. Principal Component Analysis (PCA) and Variable Importance in Projection (VIP) analyses successfully demonstrated the discriminative power of these parameters among the groups. : The increased SDF-4 levels and disturbances in the thiol-disulfide balance observed in this study indicate elevated oxidative stress and impaired cellular redox homeostasis in CAD. These findings suggest that SDF-4 and thiol-disulfide parameters may serve as important biochemical markers in the pathophysiology of CVD and hold potential as diagnostic and prognostic biomarkers. - Source: PubMed
Publication date: 2025/12/18
Bağış Murat ZiyaErsöz EzharKoyuncu İsmailEği KadirAmaç Bişar - Cervical cancer is among the prevalent gynecological malignancies affecting women worldwide. The diverse cellular populations and their intricate communication patterns within the tumor environment significantly influence cancer development and metastasis. Our research focused on elucidating the cellular diversity, intercellular signaling networks, and underlying molecular processes in cervical cancer tissues via single-cell transcriptomic approaches. - Source: PubMed
Publication date: 2025/11/25
Zhuang ShaoliDeng XiaoxiaoFu FurongZhang Zhang - Scorpion envenomation presents with a wide spectrum of clinical manifestations, ranging from mild local symptoms to severe systemic complications. This study aimed to evaluate the diagnostic and prognostic utility of GPX4, IL-13, periostin, SDF-4, and thiol/disulfide homeostasis parameters in adult patients with confirmed scorpion envenomation. - Source: PubMed
Publication date: 2025/11/06
Buyukaslan HasanKoçakoğlu Şenay - This study explores the relationship between oxidative - antioxidative balance and stromal cell-derived factor-4 (SDF-4) levels in individuals with Generalized Anxiety Disorder (GAD), aiming to clarify their roles in the disorder's pathophysiology. By examining these biomarkers, the research investigates whether oxidative stress mechanisms contribute to GAD. A cross-sectional study was conducted with 43 GAD patients and 40 age- and sex-matched healthy controls. Participants were assessed using the Beck Anxiety Inventory (BAI) and the Structured Clinical Interview for DSM-5. Serum levels of SDF-4, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were measured. GAD patients showed significantly higher levels of SDF-4, TAS, TOS, and OSI compared to controls (< 0.001). No significant differences were found in other hematological parameters. In the GAD group, SDF-4 levels were not significantly correlated with anxiety severity or oxidative markers. ROC analysis indicated good diagnostic performance of SDF-4 for GAD (AUC = 0.870). The findings suggest that oxidative - antioxidative imbalance and elevated SDF-4 levels may play a role in GAD. SDF-4 might represent a compensatory response to oxidative stress. Elevated TAS levels may indicate enhanced antioxidant defense. Further studies are needed to clarify the mechanistic and therapeutic implications. - Source: PubMed
Publication date: 2025/10/06
Çetİn Sidika BazikiAtilan Fedai ÜlkerAkil ÖznurKoyuncu İsmailDoğan Koçbaba Merve - Oral squamous cell carcinoma (OSCC) is a major public health concern in India, ranking first in cancer-related mortality among men and fourth among women, causing about nine deaths per hour. Despite advances in clinical management, prognosis remains poor due to late-stage detection and a lack of reliable biomarkers for early diagnosis and disease monitoring. This study aimed to identify salivary biomarkers and enriched protein domain/motif families for early OSCC detection and progression assessment, including lymph node invasion, in the Indian population. Using diaPASEF-based comparative salivary proteomics, 45 saliva samples from healthy individuals, premalignant lesions (PM), and OSCC patients (with/without nodal invasion) were analyzed and validated through public data sets and targeted proteomics. A total of 1068 proteins were identified, with significant differential expression across disease stages. Enriched domain/motif families included ITIs, lipocalins, calcium-binding EF-hand motifs, SERine Proteinase Inhibitors (SERPINs), trypsin-like serine proteases, and annexin repeats. Functional enrichment revealed pathways related to endopeptidase regulation, wound healing, and calcium ion binding. Key multiclass biomarkers, NUCB2, ITIH4, ITIH2, RBP4, CALU, and SDF4, achieved area under the curve (AUC) > 0.7 in receiver operating characteristic (ROC) models across our data, The Cancer Genome Atlas (TCGA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC), and were validated using parallel reaction monitoring (PRM). These findings highlight novel non-invasive salivary biomarkers with potential for early OSCC detection and lymph node invasion prediction. - Source: PubMed
Publication date: 2025/09/18
Singh AvinashSharma PratibhaBalasubramani AditiShetty Sathwik PrakashRoy SudeshVasudeva Subhash BeloorPatil SeemaVaish RichaNair SudhirSrivastava Sanjeeva