Ask about this productRelated genes to: DHRS7B antibody
- Gene:
- DHRS7B NIH gene
- Name:
- dehydrogenase/reductase 7B
- Previous symbol:
- -
- Synonyms:
- DKFZp566O084, MGC8916, CGI-93, SDR32C1
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-15
- Date modifiied:
- 2016-10-05
Related products to: DHRS7B antibody
Related articles to: DHRS7B antibody
- The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states along with Ab diversification. However, there is little information about lymphoid-cell-intrinsic functions of enzymes that mediate ether lipid biosynthesis. Imaging mass spectrometry (IMS) results had indicated that concentrations of a number of these phospholipids were substantially enhanced in GC compared to the background average in spleens, but it was unclear if biosynthesis in B cells was a basis for this finding, or whether cell-intrinsic biosynthesis contributes to B cell physiology or Ab responses. Ether lipid biosynthesis can involve the enzyme PexRAP, encoded by the gene. Using IMS and immunization experiments in mouse models with inducible loss of function, we now show that B-lineage-intrinsic expression of PexRAP promotes the magnitude and affinity maturation of a serological response. Moreover, the data revealed a -dependent increase in ether phospholipids in primary follicles with a more prominent increase in GC. Mechanistically, PexRAP impacted B cell proliferation via enhanced survival associated with controlling levels of ROS and membrane peroxidation. These findings reveal a vital role of this peroxisomal enzyme in B cell homeostasis and the physiology of humoral immunity. - Source: PubMed
Publication date: 2026/04/27
Cho Sung HoonJones Marissa AMeyer KaylorAnderson David MChetyrkin SergiyCalcutt M WadeCaprioli Richard MSemenkovich Clay FBoothby Mark R - Plasmalogens are ether lipids that constitute mammalian membranes. In their biosynthetic pathway, DHRS7B functions as an alkylglycerone phosphate reductase. Here, we have investigated whether DHRS7, which shares high sequence similarity with DHRS7B, also contributes to plasmalogen production. We generated DHRS7 and DHRS7B knockout (KO) cells, as well as double-KO cells, and quantified ethanolamine plasmalogens (PE[P]s). DHRS7 and DHRS7B were involved in the production of distinct fatty acid species: in the de novo synthesis pathway, DHRS7 contributed most strongly to the synthesis of C18:1 species, followed by C16:0 and C22:4 species, whereas DHRS7B contributed to the synthesis of all species examined. These differences in contribution in the de novo pathway resulted in further differences in the steady-state composition of PE[P]s. DHRS7 and DHRS7B also showed different intracellular localization: endoplasmic reticulum for DHRS7 and peroxisomes for DHRS7B. In vitro, DHRS7 exhibited both alkyl- and acyl-glycerone phosphate reductase activities, similar to DHRS7B. Collectively, our findings indicate that DHRS7 is a previously unreported acyl- and alkyl-glycerone (acyl/alkyl-glycerone) phosphate reductase that differs from DHRS7B in both subcellular localization and the profile of plasmalogen species produced. - Source: PubMed
Publication date: 2026/05/05
Takahashi TengaOtsuka KentoSassa TakayukiKihara Akio - The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states as well as Ab diversification. However, there is little information about lymphoid cell-intrinsic functions of enzymes that mediate ether lipid biosynthesis, including a major class of membrane phospholipids. Imaging mass spectrometry (IMS) results had indicated that concentrations of a number of these phospholipids were substantially enhanced in GC compared to the background average in spleens. However, it was not clear if biosynthesis in B cells was a basis for this finding, or whether such cell-intrinsic biosynthesis contributes to B cell physiology or Ab responses. Ether lipid biosynthesis can involve the enzyme PexRAP, the product of the gene. Using combinations of IMS and immunization experiments in mouse models with inducible loss-of-function, we now show that B lineage-intrinsic expression of PexRAP promotes the magnitude and affinity maturation of a serological response. Moreover, the data revealed a -dependent increase in ether phospholipids in primary follicles with a more prominent increase in GC. Mechanistically, PexRAP impacted B cell proliferation via enhanced survival associated with controlling levels of ROS and membrane peroxidation. These findings reveal a vital role of this peroxisomal enzyme in B cell homeostasis and the physiology of humoral immunity. - Source: PubMed
Publication date: 2025/11/06
Cho Sung HoonJones Marissa AMeyer KaylorAnderson David MChetyrkin SergeiCalcutt M WadeCaprioli Richard MSemenkovich Clay FBoothby Mark R - Recent advances in "omics" technologies have enabled the identification of new beef quality biomarkers and have also allowed for the early detection of quality defects such as dark-cutting beef, also known as DFD (dark, firm, and dry) beef. However, most of the studies conducted were carried out on a small number of animals and mostly applied gel-based proteomics. The present study proposes for the first time a Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) proteomics approach to characterize and comprehensively quantify the post-mortem muscle proteome of DFD (pH ≥ 6.2) and CONTROL (5.4 ≤ pH ≤ 5.6) beef samples within the largest database of DFD/CONTROL beef samples to date (26 pairs of the Longissimus thoracis muscle samples of young bulls from Asturiana de los Valles breed, n = 52). The pairwise comparison yielded 35 proteins that significantly differed in their abundances between the DFD and CONTROL samples. Chemometrics methods using both PLS-DA and OPLS-DA revealed 31 and 36 proteins with VIP > 2.0, respectively. The combination of different statistical methods these being Volcano plot, PLS-DA and OPLS-DA allowed us to propose 16 proteins as good candidate biomarkers of DFD beef. These proteins are associated with interconnected biochemical pathways related to energy metabolism (DHRS7B and CYB5R3), binding and signaling (RABGGTA, MIA3, BPIFA2B, CAP2, APOBEC2, UBE2V1, KIR2DL1), muscle contraction, structure and associated proteins (DMD, PFN2), proteolysis, hydrolases, and activity regulation (AGT, C4A, GLB1, CAND2), and calcium homeostasis (ANXA6). These results evidenced the potential of SWATH-MS and chemometrics to accurately identify novel biomarkers for meat quality defects, providing a deeper understanding of the molecular mechanisms underlying dark-cutting beef condition. - Source: PubMed
Publication date: 2024/07/31
González-Blanco LauraOliván MamenDiñeiro YolandaBravo Susana BSierra VerónicaGagaoua Mohammed - Periodontitis is considered to be the leading cause of tooth loss in adults, and it interacts with some serious systemic diseases. Periodontal basic therapy is the cornerstone of periodontal disease treatment and long-term maintenance and has a positive impact on the treatment of systemic diseases. - Source: PubMed
Publication date: 2022/09/29
Jin YingWang YeLin Xiaoping