Ask about this productRelated genes to: TGOLN2 antibody
- Gene:
- TGOLN2 NIH gene
- Name:
- trans-golgi network protein 2
- Previous symbol:
- -
- Synonyms:
- TGN51, TGN46, TGN48, TGN38, TTGN2
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-07
- Date modifiied:
- 2014-11-19
Related products to: TGOLN2 antibody
Related articles to: TGOLN2 antibody
- The lysosome is not only a degradative organelle but also an essential platform for signal transduction, such as with MTOR signaling. The reciprocal regulation between the lysosome and MTOR is central to macroautophagy/autophagy and metabolism. MTOR-mediated suppression of lysosomal acidification is important for lysosomal activity, autophagic flux, and cell survival. VASN is a transmembrane glycoprotein whose function is not fully understood. In the present study, we report that VASN is a TGFB-inducible protein and plays a crucial role in positively regulating lysosomal acidification. As a potential mechanism, we demonstrated that VASN localizes to the lysosome, interacts with lysosomal MTOR and STK11IP, and disrupts the binding of STK11IP to MTOR and the V-ATPase, which was recently reported to suppress lysosomal acidification. We found that VASN's function in modulating lysosomal activity is essential for optimal mitophagy induced by TGFB and terminal erythroid differentiation and is critical for the progression of mutant KRAS-driven lung cancer. Overall, our study identified VASN as a novel TGFB-inducible regulator of lysosomal function.: ATG5, autophagy related 5; BNIP3, BCL2 interacting protein 3; BNIP3L, BCL2 interacting protein 3 like; CLEM, correlative-light electron microscopy; DSP, dithiobis(succinimidyl propionate); EGFP, enhanced green fluorescent protein; EYFP, enhanced yellow fluorescent protein; FIB-SEM, focused ion beam-scanning electron microscopy; LAMP1, lysosomal-associated membrane protein 1; LysoIP, lysosomal immunoprecipitation; MAP1LC3B, microtubule-associated protein 1 light chain 3 beta; MTOR, mechanistic target of rapamycin kinase; RBCs, red blood cells; SMAD, SMAD family member; STK11IP, serine/threonine kinase 11 interacting protein; TEM, transmission electron microscopy; TGFB, transforming growth factor beta; TGOLN2/TGN38, trans-golgi network protein 2; TMEM192, transmembrane protein 192; V-ATPase, vacuolar-type H-translocating ATPase. - Source: PubMed
Publication date: 2026/02/15
Yan JiongZhang YanChoksi SwatiMikolaj Melissa RHarned AdamNarayan KedarLiu Zheng-Gang - The interaction between HIV-1 and host immune cells, particularly macrophages, is crucial in understanding viral persistence and pathogenesis. This study aims to explore the impact of HIV-1 infection on macrophage microRNA (miRNA) expression profiles using a systems biology approach to uncover the potential role of miRNAs in modulating macrophage functionality and identify key miRNA targets that may serve as therapeutic avenues. - Source: PubMed
Publication date: 2025/05/01
Harshithkumar RKaul MollinaChandane-Tak MadhuriSiddiqi Nikhat JMalik AbdulKhan Abdul ArifMukherjee Anupam - Intramuscular fat (IMF) not only directly affects the tenderness, juiciness, and overall flavour of meat but also plays a significant role in influencing consumer preferences for pork. Therefore, exploring key biomarkers that influence IMF deposition is highly important for breeding high-quality pork. IMF is a typical quantitative trait that is regulated by the interaction of multiple coding and noncoding RNAs. Traditional differential analysis methods typically focus on individual genes, making it difficult to identify key genes and their underlying mechanisms accurately. Weighted gene coexpression network analysis (WGCNA) is an efficient and accurate method for identifying and characterizing key pathways and genes associated with complex traits. Therefore, the aim of this study was to construct an mRNA‒lncRNA coexpression network related to IMF using WGCNA to explore and identify potential candidate genes that influence IMF in pigs. - Source: PubMed
Publication date: 2025/03/11
Li WenqiangYang SuozhouLiu HuixinCao ZhiXu FeiNing ChaoZhang QinWang DanTang Hui - Conventional approaches to predict protein involvement in cancer often rely on defining either aberrant mutations at the single-gene level or correlating/anti-correlating transcript levels with patient survival. These approaches are typically conducted independently and focus on one protein at a time, overlooking nucleotide substitutions outside of coding regions or mutational co-occurrences in genes within the same interaction network. Here, we present CancerHubs, a method that integrates unbiased mutational data, clinical outcome predictions and interactomics to define novel cancer-related protein hubs. Through this approach, we identified TGOLN2 as a putative novel broad cancer tumour suppressor and EFTUD2 as a putative novel multiple myeloma oncogene. - Source: PubMed
Ferrari IvanDe Grossi FedericaLai GiancarloOliveto StefaniaDeroma GiorgiaBiffo StefanoManfrini Nicola - Early prediction and prevention of recurring illness is critical for improving the survival rates of patients with non-small cell lung cancer (NSCLC). Previously, we demonstrated that the presence of premalignant epithelial changes in the small bronchi distant to the primary tumor is associated with NSCLC progression: isolated basal cell hyperplasia (iBCH) indicates a high risk of distant metastasis, BCH combined with squamous metaplasia (BCH) - a high risk of locoregional recurrence. Here, we aimed to identify germline single nucleotide variants (SNVs) and insertions and deletions (InDels) associated with distant metastasis and locoregional recurrence in cases with iBCH and BCH using whole-exome sequencing of 172 NSCLC patients. The rs112065068 of the TGOLN2 gene was identified only in iBCH patients and was associated with a high risk of distant metastasis (P < .001) and worse metastasis-free survival (HR = 4.19 (95 %CI 1.97-8.93); P < .001). This variant was validated in a group of 109 NSCLC patients using real-time PCR and Sanger sequencing analyses. To our knowledge, this study is the first to identify a germline variant associated with NSCLC distant metastasis. - Source: PubMed
Publication date: 2024/04/24
Gerashchenko TatianaSkitchenko RostislavKorobeynikova AnastasiaKuanysheva KristinaKhozyainova AnnaVorobiev RostislavRodionov EvgenyMiller SergeyTopolnitsky EvgenyShefer NikolayAnisimenko MaximZhuikova LiliaVashisth MrinalPankova OlgaPerelmuter VladimirRezapova ValeriaArtomov MykytaDenisov Evgeny