Ask about this productRelated genes to: TMEM187 antibody
- Gene:
- TMEM187 NIH gene
- Name:
- transmembrane protein 187
- Previous symbol:
- CXorf12
- Synonyms:
- ITBA1, DXS9878E
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-07
- Date modifiied:
- 2014-11-19
Related products to: TMEM187 antibody
Related articles to: TMEM187 antibody
- Erythropoiesis, the process of red blood cell production, is highly dependent on iron uptake via transferrin and its receptor, transferrin receptor 1 (TfR1), but the mechanisms governing the proper recycling of TfR1 in relation to cellular iron demands remain elusive. Here, we identify human TMEM187, a Golgi transmembrane protein of unknown function, as a novel negative regulator of erythropoiesis. Lack of TMEM187 in a cell model initiates erythropoiesis without the normal induction protocol and accelerates iron uptake. Following the induction protocol, TMEM187 ablation leads to premature erythroid maturation, resulting in early phosphatidylserine ectopia and cell membrane fragility, hallmarks of cellular senescence that renders the cells susceptible to macrophage recognition and phagocytosis. In zebrafish embryos, tmem187 deletion leads to enhanced early erythropoiesis, although the phenotype is later compensated, whereas hematopoietic stem-cell expression of human TMEM187 in mice, which lack endogenously a homologous gene, resulted in compromised erythropoiesis and moderate anemia. Mechanistically, we demonstrate that TMEM187 interacts with RAB11 to restrain endosomal recycling, interfering with RAB11-GRAB association that activates RAB11. Consequently, TMEM187 modulates TfR1 recycling to the cell membrane to fine-tune iron uptake efficiency for erythropoiesis. Our findings reveal a novel modulatory pathway in which TMEM187 plays a crucial role in regulating erythroid differentiation, maturation, and senescence, providing a previously unexplored perspective of TMEM187's physiological function. - Source: PubMed
Publication date: 2026/03/13
Liu YutongZhang WenxinCai JingZhou DiZhao HongtingDong WeichenZhao BiaoLu YaoHao ShuangyingDing YibingJiang NizhenQiao TongLi Kuanyu - Osteoporosis (OP), the "silent epidemic" of our century, poses a significant challenge to public health, predominantly affecting postmenopausal women and the elderly. It evolves from mild symptoms to pronounced severity, stabilizing eventually. Unique among OP's characteristics is the altered metabolic profile of affected cells, particularly in pyrimidine metabolism (PyM), a crucial pathway for nucleotide turnover and pyrimidine decomposition. While metabolic adaptation is acknowledged as a therapeutic target in various diseases, the specific role of PyM genes (PyMGs) in OP's molecular response remains to be clarified. - Source: PubMed
Publication date: 2024/05/22
Feng ZichenWu ZixuanZhang Yongchen - X chromosome has been considered as a risk factor for SLE, which is a prototype of autoimmune diseases with a significant sex difference (female:male ratio is around 9:1). Our study aimed at exploring the association of genetic variants in X chromosome and investigating the influence of trisomy X in the development of SLE. - Source: PubMed
Publication date: 2024/03/08
Tangtanatakul PattarinLei YaoJaiwan KrisanaYang WanlingBoonbangyang ManonKunhapan PunnaSodsai PimpayaoMahasirimongkol SurakamethPisitkun PrapapornYang YiEu-Ahsunthornwattana JakrisAekplakorn WichaiJinawath NatiniNeelapaichit NareemarnHirankarn NattiyaWang Yong-Fei - Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk alleles explain 40% of the genetic component of CeD, so there have been continuing efforts to uncover non-HLA loci that can explain the remaining heritability. As in most autoimmune disorders, the prevalence of CeD is significantly higher in women. Here, we investigated the possible involvement of the X chromosome on the sex bias of CeD. - Source: PubMed
Publication date: 2023/12/11
Hernangomez-Laderas AlbaCilleros-Portet AriadnaMartínez Velasco SilviaMarí SergiLegarda MaríaGonzález-García Bárbara PaolaTutau CarlosGarcía-Santisteban IraiaIrastorza IñakiFernandez-Jimenez NoraBilbao Jose Ramon - Osteoporosis (OP), often referred to as the "silent disease of the twenty-first century," poses a significant public health concern due to its severity, chronic nature, and progressive course, predominantly affecting postmenopausal women and elderly individuals. The pathogenesis and progression of this disease have been associated with dysregulation in tumor metabolic pathways. Notably, the metabolic utilization of glutamine has emerged as a critical player in cancer biology. While metabolic reprogramming has been extensively studied in various malignancies and linked to clinical outcomes, its comprehensive investigation within the context of OP remains lacking. - Source: PubMed
Publication date: 2023/09/14
Wang LeiDeng ChaoshengWu ZixuanZhu KaidongYang Zhenguo