Ask about this productRelated genes to: ST3GAL1 antibody
- Gene:
- ST3GAL1 NIH gene
- Name:
- ST3 beta-galactoside alpha-2,3-sialyltransferase 1
- Previous symbol:
- SIAT4A
- Synonyms:
- ST3O, SIATFL, ST3GalA.1
- Chromosome:
- 8q24.22
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-12
- Date modifiied:
- 2014-11-19
Related products to: ST3GAL1 antibody
Related articles to: ST3GAL1 antibody
- Electronegative low-density lipoprotein (L5-LDL) drives vascular injury in metabolic syndrome (MetS), yet its hepatic origin remains undefined. Here, we identify a lysophosphatidylcholine (LPC)-hypoxia-inducible factor-1α (HIF-1α) axis that governs apolipoprotein E (apoE) glycosylation and lipoprotein electronegativity. LPC activates HIF-1α in hepatocytes, inducing polypeptide -acetylgalactosaminyltransferase (GALNT2) and ST3 β-galactodise α-2,3-sialyltransferase 1 (ST3GAL1) to promote apoE -glycosylation and sialylation. This remodeling redirects lipoprotein uptake from the LDL receptor (LDLR) to lectin-like oxidized LDL receptor-1 (LOX-1), facilitating the formation of electronegative very low-density lipoprotein (V5-VLDL) and L5-LDL. Consistently, V5-VLDL from MetS subjects exhibits hyperglycosylated apoE mirroring L5-LDL. Disruption of this pathway attenuates apoE modification and LOX-1 engagement. These findings establish a mechanistic link between hepatic lipid remodeling and vascular inflammation and suggest a therapeutic strategy for targeting residual cardiovascular risk. - Source: PubMed
Publication date: 2026/06/05
Chan Hua-ChenChan Hsiu-ChuanWang Liu-FangChan Mei-LinHuang Wen-ChienBender DanielKo Yu-MinYu Ming-LungKe Guan-MingChou Mei-ChuanLiu Ching-KuanKe Liang-Yin - Glycan sialylation is vital for proper cellular function and signaling. The six-membered ST3GAL family of sialyltransferases catalyzes the transfer of sialic acid in an α2,3-linkage to galactose residues on the outermost glycan epitopes. Dysregulation of sialyltransferase activity has been linked to diverse pathological processes. To expand our understanding of the substrate specificity and cooperative function of the ST3GAL family enzymes in protein and lipid glycosylation, we systematically analyzed the function of individual ST3GAL enzymes in glycan biosynthesis using a panel of CRISPR/Cas9-engineered human keratinocyte (N/TERT-1) cell lines with single or combined ST3GAL gene knockouts (KO). For protein glycosylation, KO of ST3GAL1 reduced sialylation of type 3 epitopes (Galβ1,3-GalNAc-) on both core 1 and 2 O-glycans, while complete ablation of sialylation was observed for the combined ST3GAL1 and ST3GAL2 KO. ST3GAL2 KO alone had limited effect, but reduced sialylation of specifically core 1 O-glycans. KO of ST3GAL4 and the combined KO of ST3GAL4 and ST3GAL6 reduced sialylation of type 1 and 2 epitopes (Galβ1,3/4-GlcNAc-) on both N- and O-glycans, while no effect was observed for the single KO of ST3GAL6. In GSL glycan biosynthesis, ST3GAL5 regulated lactosylceramide sialylation, as anticipated. ST3GAL2 and ST3GAL6 mediate sialylation of type 3 motifs, whereas ST3GAL3 and ST3GAL6 target type 2 epitopes, with ST3GAL3 exhibiting no discernible preference between type 1 and type 2 substrates. Our findings reveal that glycosyltransferase specificities are shaped by substrate availability, epitope distribution across glycan classes, and enzyme competition, which can only be captured by investigating this within the cellular context. - Source: PubMed
Publication date: 2026/06/11
Hipgrave Ederveen Agnes LSong MingZhang TaoAngeren JordyBagdonaite IevaDabelsteen SallyWandall Hans Hde Haan Noortje - Indonesian sheep, shaped by survival, reproduction and productivity in humid tropical climates, may carry genomic regions associated with local adaptation and economically important traits that remain largely unexplored. This study performed genetic diversity analysis on 17,534 SNPs derived from the OvineSNP50 BeadChip genotyping array, involving 120 individuals among five local Indonesian sheep breeds: Batur, Garut, Sakub, Sumatra and Thin-tail. Analysis of genetic structure, incorporating PCA, maximum-likelihood phylogenetics analysis and Admixture analyses, demonstrated that each population displayed a uniquely homogeneous and distinctive ancestry profile, with the exception of Sakub and Thin-tail. Additionally, a close genetic relationship among Sakub, Garut and Thin-tail sheep was identified. We employed four complementary approaches of within and cross population selection signature analyses to identify putative selection signatures within 13 genomic regions. Several genes identified within the selection signature regions are potentially associated with the immune system (e.g., , and ), wool traits and pigmentation (e.g., and ), reproductive traits (e.g., and ), milk traits (e.g., and ), meat traits (e.g., and ), and adaptive traits (e.g., and ). Understanding the candidate genomic areas under selective pressure in sheep breeds may aid in identifying the associated genes and improve our comprehension of their involvement in local adaptation. Consequently, this research provides a preliminary genomic resource for the conservation and utilization of these sheep genetic resources in Indonesia. - Source: PubMed
Publication date: 2026/06/01
Astuti Putri KusumaMizeranschi Alexandru EugeniuHerdis HerdisSitaresmi Pradita IustitiaIbrahim AlekPrastowo SigitWidyas NuzulNugroho TristiantoKusza Szilvia - To investigate the role of ST3 β-galactoside α-2,3-sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF-R2) in endometrioid-type epithelial ovarian cancer (E-OC) because aberrant α2,3-sialylation mediated by ST3Gal1 and VEGF-R2-related angiogenesis is linked with tumor progression. - Source: PubMed
Publication date: 2026/05/04
Chao Wei-TingLiu Chia-HaoYang Szu-TingLin Chen-HaoWang Liang-WeiWang Peng-Hui - Bone tuberculosis is characterized by severe bone destruction driven by aberrant osteoclast overactivation. However, the direct mechanism by which Mycobacterium tuberculosis (Mtb) mediates this pathological process remains unclear. Understanding the molecular basis of pathogen-driven osteoclast dysregulation is essential for developing effective host-directed therapeutic strategies. - Source: PubMed
Publication date: 2026/04/02
Jiang ZhiweiZhang ZiyangZhang DongyangYu QixiuDeng JiezhongQu YingYang YushengZhang ZehuaGuo ShuquanZhang JieDou CeLuo Fei