Ask about this productRelated genes to: B4GALNT1 antibody
- Gene:
- B4GALNT1 NIH gene
- Name:
- beta-1,4-N-acetyl-galactosaminyltransferase 1
- Previous symbol:
- GALGT, SPG26
- Synonyms:
- beta1-4GalNAc-T
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-29
- Date modifiied:
- 2016-02-22
Related products to: B4GALNT1 antibody
Related articles to: B4GALNT1 antibody
- Measurement of enzyme activity of glycosyltransferases enables the direct observation of the reaction of substrate specificity, enzyme kinetics, and interaction with other molecules. Cell-membrane fractionations containing glycosyltransferases are collected by nitrogen cavitation, and are utilized for enzyme reaction in cell-free glass tubes. Thin-layer chromatography is used to separate reaction products, and the products are visualized by an imaging analyzer. Here, we describe the whole method in detail and step by step. - Source: PubMed
Bhuiyan Robiul HasanYesmin FarhanaFurukawa KeikoOhmi YuhsukeFurukawa Koichi - Pediatric brain tumors, particularly pontine diffuse midline glioma (pDMG), remains lethal with limited therapeutic options. Improved stereotactic biopsy techniques and advances in bioinformatics are progressively enabling deeper exploration of immunological vulnerabilities empowering novel strategies, including adoptive cell and gene therapies (ACGTs). We aimed to integrate genomic, transcriptomic, and immunological analyses to identify actionable pathways, surface antigens, and neoantigens that could inform next-generation immunotherapies, including Chimetic Antigen Receptor (CAR)-T cells and T cell Receptor (TCR)-T cell strategies. - Source: PubMed
Publication date: 2026/07/27
Rovesti GiuliaWoodbridge Alejandro FernandezYao HaidongPancaldi AlessiaChiavelli ChiaraGatto FrancescaSandvick UlrikaSällberg MattiFuxe JonasDominici MassimoGrönlund HansNilsson Ola BNascimento Silva DanielaPasetto Anna - Glycosphingolipids (GSLs) are glycoconjugates in which a short and heterogeneous saccharide chain is attached to a lipid moiety called ceramide. Based on their sugar backbone, mammalian GSLs are primarily grouped into the ganglio-, lacto-/neolacto-, and globo-series. Sialic acid-containing GSLs are known as gangliosides. Complex ganglio-series gangliosides are particularly abundant in the brain, whereas simple ganglio-series gangliosides, as well as those belonging to other series or neutral GSLs, are less abundant and typical of non-neural tissues. Congenital disorders in the biosynthesis of the lipid moiety of sphingolipids (SLs) result from defects in enzymes and proteins involved in ceramide biosynthesis and transport. Congenital disorders in the biosynthesis of the sugar chain of GSLs specifically affect ganglio-series ganglioside biosynthesis and are caused by pathogenic variants in GM3 synthase (ST3GAL5) or GM2/GD2/asialo-GM2 synthase (B4GALNT1). Defective variants of the sialyltransferase ST3GAL3 and the galactosyltransferase B4GALT5 have been reported and proposed to impair GSL biosynthesis. The occurrence of these syndromes has provided new insights into the physiological and pathological roles of GSLs. Most of these disorders are associated with completely inactive enzyme variants, leading to severe neurological syndromes. Only a few cases highlighted variants that retained partial activity, resulting in milder phenotypes, which included non-syndromic intellectual disability. It is therefore conceivable that many undiagnosed patients, with mild neurological symptoms, may carry variants retaining residual enzyme activity, insufficient to ensure normal levels of brain GSLs. The purpose of this article is to encourage clinicians to look for additional GLS hereditary disorders associated with a milder phenotype. We also hope to boost future investigations by highlighting the most critical issues emerging from recent literature on SL and GSL biosynthesis and their related defects. - Source: PubMed
Publication date: 2026/07/03
Montavoci LindaDei Cas MichelePenati SaraTrinchera Marco - Hereditary spastic paraplegia (HSP) comprises a heterogeneous group of inherited neurodegenerative disorders characterized by progressive spasticity and weakness primarily of the lower extremities. Data describing pediatric HSP from the Levant region remain limited. - Source: PubMed
Publication date: 2026/07/14
Habanjar DimaKreidly SihamTrad SamahBoustany Rose-Mary - Osteosarcoma (OS) is a malignant primary bone tumor developing from primitive mesenchymal cells. Glycosylation is important in the adhesion, metastasis and transformation of cancer cells. Nevertheless, the investigation of glycosylation-related genes (GRGs) in OS has been infrequently described. - Source: PubMed
Publication date: 2026/03/12
Ding NingLi JinlongShi SongboWang JizuDing YinliangYang Qingshan