Ask about this productRelated genes to: LRP8 antibody
- Gene:
- LRP8 NIH gene
- Name:
- LDL receptor related protein 8
- Previous symbol:
- -
- Synonyms:
- APOER2, MCI1, LRP-8, HSZ75190
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-13
- Date modifiied:
- 2015-11-13
Related products to: LRP8 antibody
Related articles to: LRP8 antibody
- Encephalitic alphaviruses, including Eastern equine encephalitis virus (EEEV), cause severe neurological disease with high mortality rates, and thus are a public health threat. Although members of the low-density lipoprotein receptor (LDLR) family, including VLDLR, LRP8 (ApoER2), and LDLR recently were identified as receptors for EEEV, residual infection in receptor-deficient cells suggests that additional entry factors exist. Using a CRISPR-based activation screen, we identified LDLR-related protein 4 (LRP4) as a candidate entry factor for EEEV and several related alphaviruses (Western equine encephalitis, Semliki Forest, and Sindbis viruses). LRP4 mediates viral attachment and internalization, and its ligand-binding domain binds directly to virions. Soluble LRP4 decoy proteins potently inhibit EEEV infection in primary mouse neuronal cells, male mice, and human brain organoids, suggesting possible therapeutic applications. Mammalian and avian LRP4 orthologs demonstrate conserved functions in promoting EEEV infection, supporting a possible role in its host range of infection and transmission. Our findings establish LRP4 as a shared entry receptor for multiple alphaviruses and expand our understanding of alphavirus tropism, pathogenesis, and countermeasure development. - Source: PubMed
Publication date: 2026/06/09
Tian SichengMa BingtingGuo HongyuanChong ZhenluGilliland Theron CHui SeanWang GuojieZhang YuyiZhou JiayueSariol AlanSun XinranHu YingxinHe ZhuohaoFremont Daved HKlimstra William BDiamond Michael SXiang YeZhang Rong - This study aimed to evaluate the contribution of hyperlipidemia-related genetic variants, including protein convertase subtilisin/kexin type 9 (; rs374603772, rs67608943, rs2182833, rs11206510), apolipoprotein E () epsilon alleles, and low-density lipoprotein receptor-related protein 8 (, also known as ; rs5174) to restenosis susceptibility in male patients with coronary artery disease (CAD) following stent implantation. - Source: PubMed
Publication date: 2026/03/27
Ozkara GulcinAslan Ezgi IrmakSer Ozgur SelimKilicarslan OnurKucukhuseyin OzlemBostan CemYildiz AhmetOzturk OguzYilmaz-Aydogan Hulya - Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limited. Here, we identify targeted degradation of the selenium uptake receptor LRP8 as an effective approach to decrease the abundance of the ferroptosis-protective enzyme glutathione peroxidase 4 (GPX4). Using bispecific cytokine receptor-targeting chimeras (KineTACs) that couple LRP8 to cytokine receptor internalization pathways, we selectively direct LRP8 to the lysosome for degradation. LRP8 degradation reduces the abundance of several selenoproteins, including GPX4, lowering the cellular threshold for lipid peroxidation and sensitizing cancer cells to ferroptosis. These findings establish receptor-mediated selenium uptake as a critical, targetable node in ferroptosis resistance and demonstrate that extracellular protein degradation can be leveraged to reprogram intracellular translational dependencies in cancer cells. More broadly, this work provides a framework for exploiting nutrient acquisition pathways to overcome therapy resistance. - Source: PubMed
Publication date: 2026/05/18
Zhao FangzhuInague AlexPeters-Clarke Trenton MChen YifeiGanjave Snehal DZhang YunMiao KunYao ZiWu YanSeto Madison K CLeung Kevin KOlzmann James AWells James A - To explore the function of the LncRNA SNHG4/miR-204-5p/LRP8 axis in the development of osteosarcoma (OS), especially in the process of epithelial-mesenchymal transition (EMT). - Source: PubMed
Publication date: 2026/05/18
Tian ZhennanQiu HuileiLang YaoguoZhou YangYu Xiangjing - Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interactions, while the pathophysiology is intricate and current treatments mainly focus on improving symptoms. Our study aims to explore potential drug targets for IBS using Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2026/04/23
Zhuo YudiZhao LuqingLi DanyanDing YangLiu NianWang YichongLiu JixiangShen ChenZhang Shengsheng