Ask about this productRelated genes to: SLC24A1 antibody
- Gene:
- SLC24A1 NIH gene
- Name:
- solute carrier family 24 member 1
- Previous symbol:
- -
- Synonyms:
- NCKX1, NCKX, RODX, KIAA0702, HsT17412, CSNB1D
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-18
- Date modifiied:
- 2016-02-17
Related products to: SLC24A1 antibody
Related articles to: SLC24A1 antibody
- To investigate the mutational characteristics of cervical cancer in Xinjiang and their relationships with tumor driver genes and affected signaling pathways. - Source: PubMed
Publication date: 2026/04/17
Chen ChaoyangZhao WenboGuo MinWang WenlingMa JieNiyazi MayinuerZhu Kaichun - Congenital stationary night blindness (CSNB) is a group of genetically and clinically heterogeneous non-progressive retinal disorders and can be classified based on fundus abnormalities as found in Oguchi disease or fundus albipunctatus (FA) or based on the absence of severe fundus abnormalities but altered electroretinography (ERG) findings. Here, we report the clinical and genetic findings of 46 CSNB families, with 18 families showing fundus abnormalities and 28 families without fundus abnormalities but having an altered ERG, showing complete CSNB (cCSNB) and Riggs type CSNB. - Source: PubMed
Publication date: 2025/06/23
Sundaramurthy SrilekhaMalaichamy SivasankarSen ParveenSachidanandam RamyaAudo IsabelleZeitz ChristinaSarangapani SripriyaSoumittra Nagasamy - Phototransduction, the process by which captured photons elicit electrical changes in retinal rod and cone cells, represents the first neuronal step in vision and involves interactions between several highly specialised proteins. Pathogenic variants in genes encoding many of these proteins can give rise to significant vision impairment, accounting for a substantial portion of inherited retinal disease. Such genes include RHO, OPN1LW, OPN1MW, GNAT1, GNAT2, GNB3, PDE6A, PDE6B, PDE6G, PDE6C, PDE6H, CNGA1, CNGB1, CNGA3, CNGB3, GRK1, SAG, ARR3, RGS9, RGS9BP, GUCY2D, GUCA1A and SLC24A1. Many of these conditions have distinct mechanisms and clinical features. They follow several modes of inheritance (including in one case digenic, or tri-allelic, inheritance). Some conditions also entail myopia. Rod and cone phototransduction will be outlined, followed by the discussion of diseases associated with these genes. Some phenotypic features will be highlighted as well as their prevalence in a large genotyped inherited retinal disease cohort. - Source: PubMed
Publication date: 2025/02/27
Wong Wendy MMahroo Omar A - Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy. Levetiracetam (LEV) is an antiepileptic drug whose mechanism of action at the genetic level has not been fully described. Therefore, the aim of the present work was to evaluate the relevant gene expression changes in the dentate gyrus (DG) of LEV-treated rats with pilocarpine-induced TLE. Whole-transcriptome microarrays were used to obtain the differential genetic profiles of control (CTRL), epileptic (EPI), and EPI rats treated for one week with LEV (EPI + LEV). Quantitative RT-qPCR was used to evaluate the RNA levels of the genes of interest. According to the results of the EPI vs. CTRL analysis, 685 genes were differentially expressed, 355 of which were underexpressed and 330 of which were overexpressed. According to the analysis of the EPI + LEV vs. EPI groups, 675 genes were differentially expressed, 477 of which were downregulated and 198 of which were upregulated. A total of 94 genes whose expression was altered by epilepsy and modified by LEV were identified. The RT-qPCR confirmed that LEV treatment reversed the increased expression of mRNA and decreased the expression of the , , , and genes in the DG. These results indicate that LEV could be involved in nonclassical mechanisms involved in Ca homeostasis and the regulation of the mTOR pathway through , , , , and , contributing to reduced hyperexcitability in TLE patients. - Source: PubMed
Publication date: 2024/01/30
Diaz-Villegas VeronicaPichardo-Macías Luz AdrianaJuárez-Méndez SergioIgnacio-Mejía IvánCárdenas-Rodríguez NoemíVargas-Hernández Marco AntonioMendoza-Torreblanca Julieta GriseldaZamudio Sergio R - In modern advanced genetics and breeding programs, the study of genes related to pigmentation in ducks is gaining much attention and popularity. Genes and DNA mutation cause variations in the plumage color traits of ducks. Therefore, discovering related genes responsible for different color traits and pigment patterns on each side of the single feathers in Chinese ducks is important for genetic studies. In this study, we collected feather images from 340 ducks and transported them into Image Pro Plus (IPP) 6.0 software to quantify the melanin content in the feathers. Thereafter, a genome-wide association study was conducted to reveal the genes responsible for variations in the feather color trait. The results from this study revealed that the pigmented region was larger in the male ducks as compared to the female ducks. In addition, the pigmented region was larger on the right side of the feather vane than on the left side in both dorsal and ventral feathers, and a positive correlation was observed among the feather color traits. Further, among the annotated genes, , , , and were identified to play important roles in the variation in pigmented regions of the various feathers. This study also revealed that five candidate genes, including , , , , and , were associated with the color pigment on the dorsal feathers of the ducks. Genes such as , , , and reportedly play important roles in ventral feather color traits. This study revealed that genes such as , DOCK1, , and were associated with different pigmentation patterns, thereby providing new insights into the genetic mechanisms of single-feather pigmentation patterns in ducks. - Source: PubMed
Publication date: 2023/12/26
Twumasi GraceWang HuazhenXi YangQi JingjingLi LiangBai LiliLiu Hehe