Ask about this productRelated genes to: PTPRA antibody
- Gene:
- PTPRA NIH gene
- Name:
- protein tyrosine phosphatase receptor type A
- Previous symbol:
- PTPRL2, PTPA
- Synonyms:
- LRP, HLPR, HPTPA, RPTPA
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1990-10-02
- Date modifiied:
- 2019-02-14
Related products to: PTPRA antibody
Related articles to: PTPRA antibody
- This article provides a comprehensive review of the molecular and neurodevelopmental mechanisms underlying schizophrenia, with a particular focus on the roles of protein tyrosine phosphatases (PTPs). Schizophrenia is a neurodevelopmental disorder with a complex etiology involving genetic and environmental factors and characterized by diverse clinical symptoms. The review synthesizes recent advances in understanding how dysregulation of specific PTPs, including PTP1B, PTP receptor gamma (PTPRG), PTPN5 (encoding striatal-enriched PTP [STEP]), and PTP receptor type A (PTPRA), contributes to disrupted synaptic signaling, neurotransmitter dysfunction, and neurodevelopmental abnormalities observed in schizophrenia. Key findings include evidence that altered phosphorylation states, impaired myelination, and aberrant modulation of N-methyl-D-aspartate (NMDA) and dopamine receptor function are central to disease pathophysiology. The review also examines the therapeutic potential of targeting PTP1B and other phosphatases, highlighting promising animal model data while emphasizing the need for additional clinical research. Collectively, the article underscores the importance of phosphatase signaling pathways in the pathogenesis and potential treatment of schizophrenia. - Source: PubMed
Publication date: 2026/01/27
Murugesan KarthikaRebellow DelvyKasagga AlousiousMon Aye MAnwar Summayya - [This retracts the article DOI: 10.3892/etm.2021.10711.]. - Source: PubMed
Publication date: 2025/12/01
Jin YanlinZhang YiLuo Xiaoming - The Xinjiang Uygur Autonomous Region of China is characterized by unique genetic and environmental factors, influenced by its geography, culture, and interethnic interactions. Understanding lipid metabolism in this population may help identify novel genetic regulators relevant to cardiovascular risk. An extreme phenotype sequencing strategy was applied to Han Chinese university students from Xinjiang. Individuals with extremely low triglyceride (TG) levels and those with normal TG levels were selected. Whole-exome sequencing was conducted, followed by bioinformatics filtering and variant prioritization based on frequency, predicted function, and phenotypic relevance. A total of 10 candidate genes (ACTN2, DHTKD1, NLRP9, PTPRA, INPP4B, PHGDH, PYROXD2, RIN1, MYRIP, and PRSS57) were identified as potentially involved in lipid metabolism regulation. Several of these genes are implicated in metabolic signaling pathways or cellular lipid processing. This study provides new insights into the genetic architecture of lipid metabolism among Han Chinese youth in Xinjiang. The identified genes warrant further validation through functional studies to elucidate their roles and potential as therapeutic targets for dyslipidemia. - Source: PubMed
Yu JiaqingMa Yitong - - Source: PubMed
Luo XuetingZhou Xiaoli - The species Ganoderma calidophilum represents a distinct variety within the genus Ganoderma and used by the indigenous Li ethnic group as a medicinal agent for the prevention and treatment of cancer. However, the precise biological activity and role of G. calidophilum in antitumor treatment remain largely unresolved. Several lanostane triterpenoids have been isolated from G. calidophilum. The enzyme activity analysis revealed that four lanostane triterpenoids exhibited PTP1B inhibition activity, with minimal inhibition towards SHP2, SHP1, PTPN5, PTPRA, STEP and TCPTP. Molecular docking analysis demonstrated that these compounds primarily bind to the substrate recognition and entry regions of PTP1B. Further analysis indicated that among them, ganoderic aldehyde A (GAA) is a selective and non-competitive PTP1B inhibitor. GAA inhibited the proliferation, colony formation and migration of C33A and MDA-MB-231 cells in a dose-dependent manner. GAA has the capacity to induce apoptosis in a cell-type-specific manner, both in a caspase-dependent and -independent manner. PTP1B siRNA significantly reduced the cytotoxic effect of GAA, while overexpression of PTP1B significantly increased cell growth after GAA treatment. These findings confirm that PTP1B is a functional target of GAA. Research into the mechanisms of action of GAA has revealed that it could inhibit the activation of AKT by inhibiting PTP1B, while simultaneously activating p38, which promotes cell death. It is possible to develop specific PTP1B inhibitors based on the lanosterol triterpene skeleton. G. calidophilum has the potential to be developed into functional foods or drugs with the aim of preventing and treating cancer. - Source: PubMed
Publication date: 2024/09/26
Chen ChuanXu RuixuanGuo ChenxiaoLi XiangkeZhao YouxingLuo Duqiang