Ask about this productRelated genes to: SLC9A7 antibody
- Gene:
- SLC9A7 NIH gene
- Name:
- solute carrier family 9 member A7
- Previous symbol:
- -
- Synonyms:
- NHE7
- Chromosome:
- Xp11.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-02
- Date modifiied:
- 2016-02-25
Related products to: SLC9A7 antibody
Related articles to: SLC9A7 antibody
- Solute carrier (SLC) family genes govern transmembrane transport and cellular metabolism, yet their systematic roles from Helicobacter pylori infection to gastric cancer (GC) remain undefined. By integrating multiple GEO datasets with weighted gene co-expression network analysis, differential expression, and machine learning algorithms, we identified seven core SLC genes (SLC9A9, SLC43A2, SLC16A6, SLC7A14, SLC28A3, SLC4A11, SLC5A2) for H. pylori infection and nine (SLC1A3, SLC2A3, SLC15A3, SLC19A3, SLC2A12, SLC16A4, SLC25A4, SLC9A7, SLC28A3) for GC. Logistic regression models achieved high diagnostic accuracy (AUC = 0.976 and 0.874, respectively). Immune infiltration analysis revealed distinct correlation patterns: SLC4A11 and SLC5A2 associated with activated mast cells, neutrophils, and M2 macrophages in infection, while SLC1A3 and SLC2A3 correlated broadly with M1/M2 macrophages and activated CD4 T cells in GC. Enrichment analyses confirmed involvement in transmembrane transport, immune-related pathways, and cancer signaling. Transcription factor prediction identified CEBPB, RELB, and STAT5A as key upstream regulators. Molecular docking demonstrated strong binding affinities between SLC proteins and repurposable compounds (3'-azido-3'-deoxythymidine, CHEMBL1182312, quinine). This study provides the first systematic characterization of SLC family expression across the H. pylori-GC continuum, identifying potential diagnostic biomarkers and therapeutic targets that warrant further experimental validation. - Source: PubMed
Publication date: 2026/07/25
Lv NuonanHe XueCai TingXu YingtingXie JieZhao XuelinYang BinfangLiu XuemeiZhang Minglin - Endometrial Cancer (EC) is one of the most prevalent malignancies in the female reproductive system. Hypoxia is a hallmark of the tumor microenvironment that drives metabolic reprogramming, endoplasmic reticulum (ER) stress, and aggressive behavior in cancer cells. However, the underlying mechanisms remain incompletely understood. This study aimed to investigate hypoxia-mediated regulation of EC progression, focusing on the role of SLC9A7 (Solute Carrier Family 9 Member A7, NHE7). - Source: PubMed
Publication date: 2026/01/23
Yang ShizhouWu TingtingCao ZhuChen ZhengyunMa YuejiangWang TingQian LinhuaHuang Xiufeng - To evaluate the clinical significance of a hemizygous c.1042-10G>C variant of the SLC9A7 gene NM_001257291.2) previously identified in individuals with neurodevelopmental disorders, and to provide an evidence-based guidance for prenatal genetic counseling. - Source: PubMed
Wang JingyuanHuang JiaZhu HongjieZhou LingxiaoYang HengYang WenjieChen ShuaiLiu Hongyan - Cadmium (Cd), classified as an International Agency for Research on Cancer (IARC) Group 1 human carcinogen, is present in cigarette smoke. Recent studies have illustrated the potential role of genetics in influencing Cd biomarker levels. - Source: PubMed
Sullivan Shannon MMurphy Sharon EStram Daniel OWilkens Lynne RHaiman Christopher ALe Marchand LoïcStepanov IrinaPark S Lani - The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD. - Source: PubMed
Belloy Michael ELe Guen YannStewart IlariaWilliams KennedyHerz JoachimSherva RichardZhang RuiMerritt VictoriaPanizzon Matthew SHauger Richard LGaziano J MichaelLogue MarkNapolioni ValerioGreicius Michael D