Ask about this productRelated genes to: PIGO antibody
- Gene:
- PIGO NIH gene
- Name:
- phosphatidylinositol glycan anchor biosynthesis class O
- Previous symbol:
- -
- Synonyms:
- DKFZp434M222, FLJ00135
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-14
- Date modifiied:
- 2016-10-05
Related products to: PIGO antibody
Related articles to: PIGO antibody
- There is no consensus regarding optimal selection of self-expandable stents (SEMS) for biliary drainage with endoscopic retrograde cholangiopancreatography (ERCP). This study compared stent dysfunction, patient survival, and adverse events in patients with unresectable malignant distal biliary strictures (DBS) treated with ERCP, randomized to partially covered (PC-SEMS) or uncovered (U-SEMS) stents. - Source: PubMed
Publication date: 2026/02/17
Cocca SilviaPigò FlaviaBertani HelgaRea RobertaPontillo GiuseppinaCampigotto MicheleGrande GiuseppeRusso SalvatoreMarocchi MargheritaLupo MarinellaPrati Gian MariaAragona GiovanniManta RaffaeleBarbera CarmeloMonica FabioDi Matteo FrancescoConigliaro RitaMangiafico Santi - : Although the incidence of infection is decreasing globally, it is not completely negligible. Because infection is associated with various pathologies, ranging from peptic ulcer disease to neoplastic lesions, research into and treatment of infections remain important. : We aimed to assess the diagnostic performance of gastric juice analysis (Endofaster) for the detection of in patients undergoing esophagogastroduodenoscopy (EGDS), using conventional histology as the reference standard. Our secondary objectives were to identify the optimal ammonium concentration thresholds for defining positive and negative results and to propose a clinical flowchart to support patient management. : The diagnostic accuracy of Endofaster was first analyzed using an unmatched training cohort comprising an equal number of -positive patients (n = 30) and negative controls (n = 30) who underwent EGDS. The derived thresholds were subsequently evaluated in an independent validation cohort of patients who underwent EGDS with Endofaster. Histological examination is the gold standard for diagnosis. : In the training cohort, an ammonium concentration cut-off of 62 ppm/mL yielded a sensitivity of 90% (95% CI: 74-97%) for ruling out infection. For confirming infection, the optimal cut-off was 100 ppm/mL, corresponding to a specificity of 95% (95% CI: 83-99%). Ammonium values > 62 and <100 ppm/mL were considered indeterminate, suggesting gastric biopsy was required for confirmation. The validation cohort included 196 patients (mean age: 59.9 ± 12.7 years), with a histology-based prevalence of 19%. In this cohort, Endofaster demonstrated a sensitivity of 70% (95% CI: 51-85%) and a specificity of 93% (95% CI: 88-97%). Indeterminate results were observed for 29 patients (15%). : Endofaster provides a largely reliable diagnosis of infection during EGDS when a decision-making approach is applied, allowing gastric biopsies to be reserved for indeterminate cases only. - Source: PubMed
Publication date: 2026/02/09
Pigò FlaviaFernicola Gian CarmineLupo MarinellaCeraso CarloEsposito LiberaBertani HelgaGrande GiuseppeCocca SilviaRusso SalvatoreMarocchi MargheritaMarsico MariaBoarino ValentinaCasciola RiccardoConigliaro Rita - Hyperphosphatasia with mental retardation syndrome (HPMRS) is a rare genetic disorder characterized by developmental delay/intellectual disability, seizures, dysmorphic features, and diverse congenital anomalies with elevated alkaline phosphatase. It is an autosomal recessive disease caused by homozygous or compound heterozygous mutations in the PIGV, PIGY, PIGO, PGAP2, PIGW, and PGAP3 genes, which are involved in glycosylphosphatidylinositol biosynthesis. Mutations in the PGAP3 gene cause HPMRS type 4. - Source: PubMed
Publication date: 2026/01/31
Beşen ŞeydaÖzkale YaseminSangün ÖzlemErol İlknur - Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy remains a challenging field in therapeutic endoscopy due to the complex anatomical reconstructions that limit access to the biliary tree. Over the past two decades, device-assisted enteroscopy (DAE), including single-balloon, double-balloon, and motorized spiral enteroscopy, has expanded the feasibility of ERCP in this population, with overall technical success rates generally reported between 70% and 90%. Nevertheless, these techniques are technically demanding, time-consuming, and frequently affected by limited reach and unstable positioning. More recently, interventional endoscopic ultrasound (EUS)-guided procedures have emerged as highly effective alternatives, significantly improving clinical outcomes in selected patients, particularly in those with long-limb Roux-en-Y reconstructions where conventional methods are less effective. Percutaneous transhepatic biliary drainage continues to represent a valuable salvage option when endoscopic approaches fail, though it is associated with a greater burden of reinterventions and adverse events. This minireview provides a comprehensive overview of the main endoscopic strategies for biliary drainage in altered anatomy, focusing on technical considerations, efficacy, and safety profiles of DAE-assisted ERCP, EUS-guided interventions, and motorized systems. The evolving landscape of biliary drainage in this setting highlights the need for tailored treatment strategies, multidisciplinary collaboration, referral to high-volume centers, and further prospective studies to refine patient selection and optimize clinical outcomes. - Source: PubMed
Cocca SilviaCasoni Pattacini GianmariaGrova AlessandroEsposito SofiaLupo MarinellaFerrante MarioGrande GiuseppeGuidotti ChiaraPigò FlaviaLi Cavoli Tancredi VincenzoMussetto AlessandroPiccoli MicaelaConigliaro RitaBertani Helga - This study investigates the clinical features and genetic mutations associated with hyperphosphatasia with impaired intellectual development syndrome-2 (HPIDS2). - Source: PubMed
Publication date: 2025/10/15
Wang XinyiZhao JingyaZhao XiaokeDing LeZhu MinLi Yang