AOC2 antibody (retina specific)
- Known as:
- AOC2 (anti-) (retina specific)
- Catalog number:
- 70r-7298
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- AOC2 antibody (retina specific)
Related genes to: AOC2 antibody (retina specific)
- Gene:
- AOC2 NIH gene
- Name:
- amine oxidase copper containing 2
- Previous symbol:
- -
- Synonyms:
- RAO, DAO2
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2019-01-18
Related products to: AOC2 antibody (retina specific)
Related articles to: AOC2 antibody (retina specific)
- This study aims to explore the potential molecular mechanisms by which di (2-ethylhexyl) phthalate (DEHP) exposure induces pulmonary arterial hypertension (PAH). - Source: PubMed
Publication date: 2026/03/20
Li HuaJiang YingchunLi Jijia - Kongshan cattle is an indigenous breed from Sichuan Province, China, characterized by their excellent meat quality, high fertility, strong disease resistance, and remarkable environmental adaptability. However, their genomic diversity has not been systematically studied. In this work, we performed whole-genome sequencing of 30 Kongshan cattle from a breeding farm and integrated these data with 113 representative commercial and indigenous cattle breeds worldwide to investigate their population structure and genetic diversity. We further analyzed the ancestral contributions to the development of the breed. The population structure revealed that Kongshan cattle possess four types of ancestral components: East Asian indicine (0.5974), East Asian taurine (0.3464), European taurine (0.0483), and Indian indicine (0.0079). The population also exhibits high nucleotide diversity, second only to pure East Asian indicine cattle. We inferred the ancestry of each variable site in the genome and, in combination with integrated haplotype score analysis, identified candidate genes related to meat quality (, , , , and ), immunity (, , , , , , , and ), and environmental adaptability (, , , , and ). These findings provide valuable insights into the evolutionary history and ancestral origins of Kongshan cattle and contribute to the broader understanding, conservation, and sustainable utilization of indigenous Chinese cattle genetic resources. - Source: PubMed
Publication date: 2025/12/12
Bai MengmengYang KaiMa XiaohuiBian ChenqiWang WeiYi JunChen NingboLei ChuzhaoXia Xiaoting - ObjectiveThis study assesses the clinical efficacy and safety of combining traditional Chinese medicine (TCM) external therapy (Xiaozhong Zhitong ointment) with volar locking plate (VLP) fixation for treating complex AO-C2/3 distal radius fractures.MethodsSixty patients with complex AO-C2/3 distal radius fractures were randomly assigned into two groups (n = 30 each). The control group received standard VLP fixation alone, while the study group additionally received external application of Xiaozhong Zhitong ointment postoperatively. Clinical endpoints included Visual Analogue Scale (VAS) score, swelling condition, Cooney scores, Generic Quality of Life Inventory-74 (GQOL-74) score, radiographic parameters (palmar tilt, ulnar variance, radial height, joint surface displacement), wrist joint mobility (flexion, extension, pronation, supination, radial and ulnar inclination), and incidence of complications.ResultsCompared to the control group, at 2- and 4-weeks postoperatively, the study group showed lower VAS scores and swelling levels ( < 0.05). The study group also exhibited higher Cooney scores at 4 weeks and 6 months postoperatively and excellent-good rate of Cooney scores at 6 months postoperatively. Additionally, the study group demonstrated better GQOL-74 scores across all dimensions at 6 months postoperatively, along with improved imaging parameters (palmar tilt, ulnar deviation, joint surface displacement) and greater wrist flexion range of motion at 12 months postoperatively (all < 0.05). There was no significant difference in complication rates between the two groups ( > 0.05).ConclusionCombining Xiaozhong Zhitong ointment with VLP fixation improves outcomes for complex distal radius fractures, reducing pain and swelling, enhancing quality of life and wrist function, with no added complication risk, making it a potential adjunct to standard care. - Source: PubMed
Publication date: 2025/12/05
Xu JiachenZhu WeiyanGu JunFeng Zheng - Sophora alopecuroides, a salt-tolerant medicinal legume, has been recognized as a promising genetic resource for saline-alkali soil remediation. Although its pharmacological properties have been extensively documented, the molecular mechanisms underlying salt tolerance remain largely unresolved. In this study, lysine decarboxylase (SaLDC), a key enzyme involved in quinolizidine alkaloid biosynthesis, was found to play a crucial role in salt stress adaptation. Transgenic Arabidopsis lines exhibited dose-dependent improvements in salt tolerance, characterized by markedly reduced Na⁺ accumulation, which contributed to enhanced K⁺/Na⁺ homeostasis, and increased Ca²⁺/Mg²⁺ retention under salinity. Multi-omics analyses revealed that SaLDC mediated a dual adaptive strategy involving metabolic reprogramming through the coordinated activation of phenylpropanoid pathways, tricarboxylic acid (TCA) cycle intermediates, and redox homeostasis via glutathione metabolism and polyamine accumulation. Notably, SaLDC overexpression simultaneously upregulated genes involved in jasmonic acid biosynthesis (AOC2 and LOX2) and modulated circadian clock components (RVE2 and CO), thereby suggesting a previously unrecognized link between stress adaptation and developmental regulation. Collectively, these results identified SaLDC as a multifunctional gene that integrated ion homeostasis, secondary metabolism, and hormonal signaling to enhance salt tolerance, while concurrently accelerating flowering and improving yield-related traits. These findings advance the current understanding of polyamine-mediated stress adaptation and provide strategic targets for breeding stress-resilient crops. - Source: PubMed
Publication date: 2025/11/19
Tian YongliWang RuiSu JingLi WenjuanLiu PingLuo ChengkeQian JiaojiaoZhang DantingLi PeifuWang BinYang RongMa TianliMa Qiaoli - Wheat (Triticum aestivum L.) production is increasingly constrained by drought, heat, and their combination, especially in arid regions like Xinjiang, China. While previous studies have focused on single-stress responses, the molecular mechanisms underlying wheat adaptation to combined drought and heat stress (HD) remain elusive. Here, we performed transcriptome profiling at three key spike developmental stages-Jointing Stage (JS), Stamen and Pistil Primordial Differentiation Stage (SPDS), and Tetrad Stage (TS)-under drought (DS), heat (HS), and combined HD conditions. Comparative analysis revealed that HD triggered the most extensive transcriptional reprogramming, with 3,884, 5,230, and 2,793 stage-specific upregulated genes across JS, SPDS, and TS, respectively. Notably, the overlap between HS- and HD-responsive genes was higher than that between DS and HD during early stages, indicating stress-specific transcriptional shifts. Functional enrichment highlighted pathways related to osmotic adjustment, oxidative defense, and phytohormone signaling, particularly ABA and JA biosynthesis. Among stress-responsive transcription factors, the AP2/ERF family showed prominent enrichment, with TaEREBP1-L (TraesCS5A02G215900) identified as a central regulator. Dual-luciferase reporter assays confirmed that TaEREBP1-L directly activated the promoters of ABA- and JA-pathway genes (AAO3, AOC2). Co-expression analysis further revealed its coordination with membrane transporters (e.g., ABC and MATE families), suggesting an integrative regulatory function under HD conditions. Transgenic Arabidopsis overexpressing TaEREBP1-L displayed significantly enhanced drought and heat tolerance, evidenced by increased proline content, antioxidant enzyme activity (SOD, CAT), and elevated ABA/JA levels. These results demonstrate that TaEREBP1-L confers broad-spectrum stress tolerance by orchestrating hormonal and physiological pathways. Our findings provide valuable insights into combinatorial stress adaptation and identify TaEREBP1-L as a promising target for improving wheat resilience under climate-related challenges. - Source: PubMed
Publication date: 2025/11/18
Han JunjieXia JianqiangWang ChunshengWang ZhenlongZhao ZhunWang ZhongZhang Yueqiang