Ask about this productRelated genes to: PERP antibody
- Gene:
- PERP NIH gene
- Name:
- p53 apoptosis effector related to PMP22
- Previous symbol:
- -
- Synonyms:
- PIGPC1, dJ496H19.1, KCP1, THW, KRTCAP1
- Chromosome:
- 6q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-19
- Date modifiied:
- 2019-01-31
Related products to: PERP antibody
Related articles to: PERP antibody
- Changes in marine animal communities shape ecological processes and ecosystem functioning. Monitoring temporal community dynamics is increasingly important under global change, yet remains challenging because community fluctuations can arise from multiple natural processes and are difficult to assess. Passive acoustic monitoring of signals produced by marine fauna offers a non-invasive means of tracking community dynamics, providing continuous, high-resolution data that capture temporal patterns often missed by traditional methods. Despite their potential as proxies for macrofaunal assemblages and associated dynamics, the responses of acoustic communities to environmental variability in marine ecosystems remain largely unexplored. This study aimed to characterize fish acoustic communities in a tidal European kelp forest and identify the environmental drivers shaping their temporal variability. Continuous acoustic recordings were combined with environmental measurements and underwater visual surveys to address these objectives. Generalized linear models revealed that diel and tidal cycles were the dominant drivers of acoustic activity, diversity, and community composition during the summer study period. Other environmental variables had weaker effects, reflecting the fauna's adaptation to marked short-term fluctuations in this dynamic ecosystem. Acoustic activity and richness increased at low water height, contrasting with higher visually observed fish abundance at high water height. This discrepancy suggests that sound production reflects behavioural interactions rather than fish abundance alone. The greater number of sound types (26) relative to observed species (19) indicates either behavioural sound diversity within species or the presence of undocumented soniferous taxa. Calmer sea conditions also promoted higher vocal activity and acoustic richness. This study provides an unprecedented description of kelp forest acoustic communities in Europe, demonstrating the value of ecoacoustics to complement visual surveys for capturing natural variability and establishing essential baseline information for detecting long-term ecological shifts in these climate-sensitive habitats. - Source: PubMed
Publication date: 2026/05/02
Ethève MarineThiriet PierreLegras GaëlleLenfant PhilippeBourrin FrançoisIorio Lucia Di - This study characterized operator eye lens exposure in over-table fluoroscopy using Monte Carlo simulation, focusing on beam quality and geometry under simulated conditions. Absorbed doses were calculated using voxel phantoms across tube voltages (75-95 kV), filtrations (Al 2.5-4.5 mm, Cu 0.0-0.5 mm), and field sizes (10-30 cm). Grid correction was applied to normalize results to detector entrance dose. Beam hardening via increased filtration significantly reduced lens doses, although the rate of dose reduction gradually diminished as Cu thickness increased. Field size reduction was the most effective strategy; a 10 cm field reduced the dose by 40-50% compared to a 30 cm field. When using Patient Entrance Reference Point (PERP) values to estimate operator lens exposure, beam quality must be considered, as the same PERP value can yield substantially different operator doses depending on filtration. Field size restriction remains the most effective measure for dose reduction. - Source: PubMed
Publication date: 2026/05/02
Tamura TakayukiHoashi KaitoMasumoto YoshifumiHamaoka Shingo - Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self-tolerance. Numerous apoptosis-related genes influence cell fate during T-cell development. The PERP protein functions in apoptosis induction and as a tumor suppressor; however, p53 targets the Perp promoter, leading to its downregulation in various cancers. We investigated the specific role of Perp by studying conditional knock-out mice exhibiting partial thymic T-cell development defects and a significant accumulation of thymic CD4SP T-cells. Ex vivo and in vivo analyses revealed that Perp regulates the survival of thymic T-cell subsets during clonal deletion, particularly CD4SP T-cells following TCR stimulation. These floxed mice also exhibited an expansion of the Helios CD4SP thymocyte population. Moreover, middle-aged floxed mice exhibited excessive accumulation of activated CD4 T-cells in peripheral blood, alongside T cell-mediated autoimmune arthritis. These findings indicate that conditional Perp knockout mice exhibit a deficiency in thymic negative selection and heightened susceptibility to autoimmunity with aging. - Source: PubMed
Zhou YanLi JunrongLeng XiaoShi JiaoZhang GanChen ShanLiu DongDeng QianHe YanShi GuixiuXu YingLiu YuanWang Yantang - Chromatin Immunoprecipitation sequencing (ChIP-seq) is the method of choice to generate chromatin landscapes across genomes. The scarcity of literature on ChIP-seq and absence of a canonical "gold standard" method in mollusks and especially the Pacific oyster Magallana gigas, prompted us to compare four chromatin profiling approaches (Native-ChIP, Crosslink-ChIP, ChIPmentation and CUT&Tag) to find the most suitable method for this species. In our hands the CUT&Tag immuno-tethering method provided most robust and reproducible signal. Our findings establish CUT&Tag as a low-background and versatile method for epigenomic studies in non-model marine organisms, enabling future comparative analyses of chromatin dynamics. - Source: PubMed
Publication date: 2026/03/26
Dellong AmélieFallet ManonStenger Pierre-LouisChaparro CristianVidal-Dupiol JeremieClément JulieGrunau ChristophCosseau Céline - Polymer-ceramic hybrid composites are emerging as attractive candidates for lightweight, corrosion-resistant absorber components in solar thermal collectors; however, their adoption is constrained by the intrinsically low thermal conductivity of polymers, processing-induced anisotropic heat transport, interfacial thermal resistance at tube/laminate joints, and durability challenges under outdoor exposure. This review provides a collector-centered synthesis of polymer-ceramic hybrid materials, emphasizing the translation of composite properties into collector-level outcomes rather than conductivity enhancement alone. A structure-property-performance mapping approach is presented to connect directional thermal conductivity ((k_in-plane), (k_perp)), thermal diffusivity, heat capacity, coefficient of thermal expansion, and service temperature with collector performance parameters such as heat removal effectiveness, overall heat losses, and stagnation behavior. Ceramic fillers (e.g., boron nitride, aluminum nitride, silicon carbide, alumina) are examined for stable conduction-network formation, coating compatibility, and long-term reliability, while carbon fillers (graphite, graphene nanoplatelets, carbon nanotubes) are evaluated for combined heat spreading and solar absorption benefits, with attention to emissivity penalties. Hybrid ceramic-carbon architectures and multilayer absorber designs are identified as the most promising routes to balance thermal transport, optical selectivity (high solar absorptance and low thermal emittance), manufacturability, and durability under UV, humidity, and thermal cycling. - Source: PubMed
Publication date: 2026/03/11
Sharma Sachin KumarPradhan ReshabSharma Lokesh KumarSharma YogeshSharma MohitPal YatendraBračun DragoKlobčar Damjan