Ask about this productRelated genes to: PTPRR antibody
- Gene:
- PTPRR NIH gene
- Name:
- protein tyrosine phosphatase receptor type R
- Previous symbol:
- PTPRQ
- Synonyms:
- PTPBR7, PTP-SL, EC-PTP, PCPTP1
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-28
- Date modifiied:
- 2019-02-14
Related products to: PTPRR antibody
Related articles to: PTPRR antibody
- The CONSTANS, CONSTANS-like, and TIMING OF CAB EXPRESSION 1 (CCT) domain proteins are key regulators of flowering time and circadian rhythms in annual plants, but their diversity and temporal expression patterns in perennial trees remain poorly understood. - Source: PubMed
Publication date: 2026/03/20
Zang RuiLi YueDai Xiaokang - KRASG12C inhibitors, such as sotorasib, show clinical efficacy for non-small cell lung cancer (NSCLC) positive for the G12C mutations of KRAS, but primary and acquired resistance to these drugs remains a clinical problem. In this study, we show that the development of resistance to sotorasib in KRASG12C-positive NSCLC cells was mediated by constitutive activation of EGFR resulting from downregulation of the protein tyrosine phosphatase receptor type R (PTPRR). PTPRR has been identified as a physiologic regulator of ERK signaling in several cancer types. In our study, PTPRR was demonstrated to bind directly to EGFR, facilitating its dephosphorylation on tyrosine residues. Resumption of PTPRR expression in the resistant cells attenuated EGFR phosphorylation and restored sotorasib sensitivity. PTPRR downregulation was associated with gene promoter hypermethylation in the sotorasib-resistant cells and NSCLC tissue samples. Furthermore, low PTPRR expression in tumor specimens was associated with shorter progression-free and overall survival for patients with NSCLC treated with sotorasib. In contrast to sotorasib, high PTPRR expression was associated with a poor response to EGFR tyrosine kinase inhibitors in EGFR-mutated NSCLC, suggesting that PTPRR may broadly regulate EGFR dependence in NSCLC. Finally, dual blockade of KRASG12C and EGFR showed a substantial antitumor effect in a xenograft model of sotorasib-resistant NSCLC. This approach is therefore a rational therapeutic strategy for KRASG12C-positive NSCLC, especially for tumors showing PTPRR downregulation. - Source: PubMed
Kanemura HiroakiTakehara ToshiyukiMaenishi OsamuTomida ShutaIwawaki NatsumiKunimasa KeiNakayama TomohiroWatanabe SatomiSuzuki ShinichiroSakai KazukoAzuma KoichiKudo KeitaNishio KazutoNakagawa KazuhikoHayashi HidetoshiTeramura TakeshiYonesaka Kimio - The biological mechanisms driving the long survival in glioblastoma (GBM). Five-year long-term survival (LTS) and 10-year survival very long-term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10-046 (VLTS) was affected by a giant cell-GBM, classified as the pedHGG_RTK1a subtype according to the v12.5 Heidelberg brain tumor methylation classifier. Somatic and germline MSH6 mutations, typically in Lynch syndrome, and high tumour mutational burden were detected. The copy number variation plots showed chromosome 1q gain and chromosome 13 loss with no other typical GBM alterations. AR10-037 (LTS) suffered from a classical GBM, identified as pedHGG_MYCN subclass. Apart from the canonical chromosome 7 gain and chromosome 10q loss, we observed MDM2 gene amplification and possible rearrangements on chromosome 12 and 18 with the typical aspect of chromothripsis, harbouring two putative new gene fusions: CPSF6::CPM and PTPRR::RAB3IP. We described two patients with peculiar tumour molecular profile, widening the scenario of clinical and molecular variability in such patients. - Source: PubMed
Anghileri ElenaMiele EvelinaPatrizi SaraBarresi SabinaLazzarini ElisabettaMaddaloni LuisaPatanè MonicaPedace LuciaPaterra RosinaSilvani AntonioLocatelli FrancoIndraccolo StefanoPollo Bianca - Honeybees are vital pollinators with functional differentiation as a key survival strategy. The Chinese honeybee () exhibits exceptional nectar foraging in complex terrains, yet how alternative splicing (AS) and polyadenylation (APA) regulate its labor division remains unclear. Here, we applied PacBio full-length transcriptome sequencing to annotate worker bee transcriptomes across three developmental stages (3d, 10d, 21d), calibrating the third-generation sequencing data with second-generation sequencing to enhance transcriptome annotation accuracy. We identified 17,961 isoforms and 1922 APA genes, finding that alternative first exon was the major type of AS, while APA enhances transcriptomic diversity via dual polyadenylation sites in most genes. Functional analyses revealed AS enrichment in growth signaling () and immune pathways (), whereas APA regulated growth signaling (), energy metabolism (), and oxidative stress (). Validation by PCR and 3'RACE confirmed stage-specific AS/APA events in key genes. These findings significantly enhance the reference genome annotation and provide valuable insights into the mechanisms of AS and APA regulation underlying honeybee development and functional transitions. - Source: PubMed
Publication date: 2025/08/14
Yao DanFan YuanchanZhou WencaiZhan HongpinYu YinglongWei Xiaoping - Growth traits are crucial for poultry breeding and production. Marker-assisted selection (MAS) and genomic selection (GS) of growth traits require a substantial number of accurate genetic markers. A genome-wide association study (GWAS) for body size traits was performed on 248 Luning chickens to identify significant single-nucleotide polymorphisms (SNPs) and insertions and deletions (INDELs) related to the growth and development of chickens. A total of 30 significant SNPs and 13 INDELs were obtained for body size traits. Two notable regions, spanning from 43.072 to 43.219 Mb on chromosome 1 and from 4.751 to 4.800 Mb on chromosome 11, were found to be significantly associated with growth traits in the GWAS of both SNPs and INDELs. Some genes, including , , , , , , , , , and , were identified as important candidate genes for the growth of chickens. The results provide valuable information for understanding the genetic basis of growth traits which is beneficial for the subsequent selective breeding in Luning chickens. - Source: PubMed
Publication date: 2025/03/27
Li ZhiyiNong YiLiu YuanWang ZiWang JiayanLi Zhixiong