Ask about this productRelated genes to: TMEM48 antibody
- Gene:
- NDC1 NIH gene
- Name:
- NDC1 transmembrane nucleoporin
- Previous symbol:
- TMEM48
- Synonyms:
- FLJ10407, NET3
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-22
- Date modifiied:
- 2015-08-25
Related products to: TMEM48 antibody
Related articles to: TMEM48 antibody
- A growing body of work has linked the dysregulation of transmembrane (TMEM) proteins to the proliferation, metastasis, drug resistance, and tumor microenvironment remodeling of lung cancer, the leading global cause of cancer mortality. Renamed members such as STING1 (stimulator of interferon response cGAMP interactor 1, TMEM173), ANO1 (anoctamin-1, TMEM16A), ORAI1 (ORAI calcium release-activated calcium modulator 1, TMEM142A), ORAI3 (TMEM142C), and NDC1 (NDC1 transmembrane nucleoporin, TMEM48) are among the most extensively studied ones. Mechanisms of TMEM dysregulation in lung cancer span the modulation of Ca influx, lysosomal exocytosis, ferroptosis, Wnt and β-catenin signaling, and immune cell infiltration and immune checkpoint rewiring, among others. Epigenetic silencing and targetable fusions (i.e., TMEM106B-ROS1 and TMEM87A-RASGRF1) create DNA-level vulnerabilities, while miRNA sponges offer RNA-level druggability. A subset of studies revealed context-specific expression (endothelial, B cell, and hypoxic EV) that can be exploited to remodel the tumor microenvironment. One study specifically focused on how isoform-specific expression and localization of TMEM88 determine its functional impact on tumor progression. Yet for most TMEMs, only pre-clinical or early-phase data exist, with many supported by a single study lacking independent validation. This review brings together scattered evidence on TMEM proteins in lung cancer, with the aim of guiding future work on their possible use as biomarkers or therapeutic targets. - Source: PubMed
Publication date: 2026/01/22
Zhang SiweiCao GuojieHu XuelinChen ChenChen Peng - A highly curved membrane region connecting the inner and the outer nuclear membrane serves as a platform where nucleoporins with one or more transmembrane domains promote anchoring of the nuclear pore complex to the nuclear envelope. In mammalian cells, three transmembrane nucleoporins, Nup210, POM121 and NDC1, are inserted at this site. Here, we characterize TMEM209, which had initially been identified as a protein concentrated at the nuclear envelope, as a fourth transmembrane nucleoporin. Proximity labeling revealed that TMEM209 is present close to proteins of the inner nuclear membrane and to other nucleoporins. TMEM209 localized to the nuclear pore complex in immunofluorescence microscopy and biochemically interacted with Nup210 via a region containing its two transmembrane domains. TMEM209 depletion impaired cell growth and delayed entry into S, G2 and M phases of the cell cycle. Conversely, its overexpression specifically dissociated Nup210 from the nuclear envelope. Together, these findings establish TMEM209 as a novel transmembrane nucleoporin that cooperates with Nup210 in cell cycle progression and cell proliferation. - Source: PubMed
Publication date: 2026/02/24
Kohlhause DavidSpillner ChristianeAlcalde Zapata VioletaLenz ChristofUrlaub HenningKohl TobiasLehnart Stephan EGerace LarryKehlenbach Ralph H - Heart failure (HF) is the final stage of cardiovascular diseases. Nicotinamide metabolism (NMN) plays a key role in cardiovascular dysfunction. We aimed to explore genes correlated with NM pathway activity (NMRGs) in HF. - Source: PubMed
Publication date: 2025/12/16
Du JianpingYang XiaoyuWu ShuxingBi ShuliWang PengCheng LisongYao Zhuhua - This study investigates the mechanisms of Osimertinib resistance in lung adenocarcinoma (LUAD) by identifying prognostic genes associated with SUMOylation. We performed differential expression analysis to identify differentially expressed genes (DEGs) in LUAD samples, Osimertinib-tolerant cell samples and SUMOylation-related genes (SRGs). Utilizing Cox regression and LASSO regression, we developed a prognostic model that highlighted five key prognostic genes-BIRC5, AURKA, BLM, NR3C2, and NDC1. These genes were significantly associated with LUAD progression, revealing their predominant expression in epithelial cells, which play a vital role in tumor development. Furthermore, we explored the biological functions and signaling pathways linked to these prognostic genes, discovering that their expression levels and corresponding risk scores could serve as indicators of CD4 T cell and memory B cell activation. The enriched signaling pathways in LUAD were regulated by ubiquitin-related small modifiers, highlighting the complex interplay between SUMOylation and tumor biology. Our findings suggest the important role of SUMOylation-regulated genes in LUAD progression and Osimertinib resistance, suggesting their potential as valuable biomarkers for prognosis and therapeutic targets to enhance treatment strategies for patients with EGFR-mutant lung adenocarcinoma. - Source: PubMed
Publication date: 2025/08/24
Yang XiaopingLiu YongjiJiang WenLiu XiaochunZhang XiaonanLiu HuiyingXing DaijunWang KeerZheng XinJiang Wenqing - Labeo calbasu (L. calbasu) is an important detrivore fish in an ecosystem. So, the present transcriptome study was undertaken in relation to polluted and non-polluted water sources from a natural perennial river system. The Illumina NovaSeq 6000 platform was used to perform transcriptome analysis on liver samples of L. calbasu that were collected from the Ganga and Yamuna rivers. From 8744 differentially expressed genes (DEGs), 2538 were upregulated, and 6206 were downregulated in response to pollution stress. Biologic process (BP), cellular component (CC), molecular function (MF), and Gene Ontology (GO) demonstrated that relevant genes were associated with peptide metabolic process, cytosol, RNA binding, etc. In the Kyoto Encyclopedia of Genes and Genome (KEGG) analysis, ribosomal and metabolic pathways were more important due to the high False discovery rate (FDR) and the involvement of many genes. Transcripts of uncertain coding potential (TUCP) and various RNAs like mRNAs and long noncoding RNAs (lncRNAs) orchestrate fish cellular responses to environmental stressors in polluted waters, where aquatic ecosystems are threatened. FGG mRNA is co-expressed in both up and down-regulation in the liver of L. calbasu. In conclusion, L. calbasu collected from the Yamuna River have highly pollution-induced ribosomal pathways involving genes like Rpl19, rpl23Ae, rps2e, rps10e, rps15e, and rps7e, etc, which is important for pollution biomarker study. RANBP2 and egr1 lncRNA are the most significantly interlinked with ndc1 and fosab lncRNA. - Source: PubMed
Publication date: 2025/04/10
Pradhan Smruti PriyambadaChakraborty Hirak JyotiGadnayak AyushmanRaut Subhashree SubhasmitaSarkar Dhruba JyotiSharma AnuMishra Dwijesh ChandraFarooqi Mohammad SamirBehera Bijaya KumarDas Basanta Kumar