Ask about this productRelated genes to: PERLD1 antibody
- Gene:
- PGAP3 NIH gene
- Name:
- post-GPI attachment to proteins 3
- Previous symbol:
- PERLD1
- Synonyms:
- MGC9753, CAB2, PP1498, PER1
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-30
- Date modifiied:
- 2014-11-19
Related products to: PERLD1 antibody
Related articles to: PERLD1 antibody
- Intestinal transcriptomic data encompass substantial value in studying inflammatory bowel disease. By analyzing intestinal gene expression profiles, this study aimed to discover transcripts exhibiting diagnostic efficacy for IBD. Intestinal transcriptomic data from 1,458 patients with Crohn's disease (CD), 1,211 patients with ulcerative colitis (UC), and 674 healthy controls were acquired by integrating seven datasets with accession numbers GSE66407, GSE193677, GSE126124, GSE83687, GSE75214, GSE36807, and GSE16879. Then, the DEGs in IBD were analyzed by ML methods to discern transcripts that hold diagnostic power. ROC analysis identified potential biomarkers, which were subsequently tested in 16 external datasets. , , , , and emerged as prominent genes based on both RF and LASSO methods. Meanwhile, only and had an AUC of the ROC curve greater than the 0.7 threshold in the integrated data. ROC analysis across 23 cohorts demonstrated that the AUC of and were above 0.7 in the majority of the cohorts, particularly that for . However, upregulated also exhibited diagnostic efficacy for autoimmune gastritis (AIG), eosinophilic esophagitis (EoE), and colorectal cancer (CRC), reflecting the substantial activation of the complement cascade in these disorders manifesting with gastrointestinal inflammation. - Source: PubMed
Publication date: 2026/08/04
Mokaram Doust Delkhah Arman - The genetic architecture of idiopathic inflammatory myopathies (IIMs) remains incompletely defined. When increasing sample size is not feasible, cross-trait analysis of genetically correlated diseases offers an effective strategy for discovering risk loci. Using summary statistics of IIM and B cell lymphoma subtypes, we applied conditional false discovery rate (condFDR) and multi-trait analysis of genome-wide association studies (GWASs) (MTAG) to detect genetic associations with IIM risk. Single-nucleotide polymorphisms (SNPs) outside the human leukocyte antigen (HLA) region meeting significance thresholds (condFDR < 0.01 or p <5 × 10 for MTAG) were clumped and subjected to both functional annotation in FUMA and Gene Ontology (GO) biological process enrichment analysis using clusterProfiler. We identified six previously unreported loci, including three associated with dermatomyositis (chr12:58674304T>C, chr13:110799415C>T, and chr17:38103285G>A (hg19)) and three associated with polymyositis (PM) (chr4:971496T>C, chr6:396321C>T, and chr6:32650631C>A). All non-HLA loci act as expression quantitative trait loci (eQTL) or localize within enhancer regions. Notably, these include cis-eQTLs for known IIM risk-associated genes (GSDMB, DGKQ, SLC26A1, and IDUA) as well as genes implicated in synaptic vesicle cycle (SVC) pathways, immune regulation (IKZF3, ORMDL3, IRF4, DUSP22, and SPON2), protein homeostasis (ATP23 and PSMD3), lipid metabolism (PGAP3, ORMDL3, STARD3, and DGKQ), and myopathy (COL4A1). GO analysis revealed significance for SVC pathways in PM (FDR < 0.05). These findings advance our understanding of IIM pathogenesis from a genetic perspective and highlight candidate regulatory variants for further mechanistic investigation. - Source: PubMed
Publication date: 2026/07/24
Che Weng IanJarvis James NSysojev Anton ÖbergZhu CatherinePatasova Karina Smedby Karin ELundberg Ingrid EWesterlind HelgaLamb Janine AHolmqvist Marie - Prostate cancer (PCa) is prototypically immunologically "cold", characterized by low tumor mutational burden, sparse CD8 T-cell infiltration, and resistance to immune checkpoint blockade. The tumor cell-intrinsic programs driving immune evasion in this context remain incompletely defined. - Source: PubMed
Publication date: 2026/03/18
Liu WeihaoLi GuopingLei YanLiu HuixiuWang BinhuiDeng WeimingHong YudeLong Xiangyang - A rare autosomal recessive disorder known as hyperphosphatasia with impaired intellectual development syndrome (HPMRS), also referred to as Mabry syndrome, is caused by a deficiency in glycosylphosphatidylinositol (GPI). Elevated blood alkaline phosphatase (ALP) levels, cognitive impairment, and epileptic seizures are among its key features. These pathways are involved in the synthesis of GPI and the transfer of GPI anchor to the proteins, fatty acid remodeling, and transport of GPI-anchored proteins (GPI-APs). - Source: PubMed
Salmaninejad ArashSeyedtaghia Mohammad RezaBereshneh Ali HosseiniAzizi NasrinBayat RezaEsnaashari SomayeAminzadeh VahidKoohmanaee ShahinSavad ShahramMojarrad MajidDalili Setila - To systematically evaluate the causal association between metabolic syndrome (MetS) and its components with gout through integrated multi-dimensional methods, and reveal the genetic basis and transcriptomic characteristics of comorbidity. - Source: PubMed
Publication date: 2026/02/18
Li JianbinZhang JiaminLi SuiranYao XiaogeLi RenheLiu Wei