Ask about this productRelated genes to: CHST13 antibody
- Gene:
- CHST13 NIH gene
- Name:
- carbohydrate sulfotransferase 13
- Previous symbol:
- -
- Synonyms:
- C4ST3
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-06
- Date modifiied:
- 2016-05-09
Related products to: CHST13 antibody
Related articles to: CHST13 antibody
- Hypopituitarism is a severe endocrine disorder characterized by a partial or complete hormone deficiency in the anterior or posterior pituitary gland. Current treatment relies on hormone replacement therapy, which is unable to mimic normal physiological circadian rhythm precisely, and long-term hormone replacement therapy can result in a variety of adverse effects. This study aimed to identify potential drug targets and clarify the mechanisms underlying hypopituitarism. To identify potential therapeutic targets for hypopituitarism, summary statistics from expression quantitative trait loci (eQTL) datasets, serum and cerebrospinal fluid (CSF) metabolites, and hypopituitarism genome-wide association study (GWAS) data were integrated for analysis. Two-sample Mendelian randomization (MR) analysis was performed to identify causal genes associated with hypopituitarism. Subsequently, the relationship between serum and CSF metabolites and hypopituitarism was investigated. Finally, a two-step MR analysis explored the mediation of these metabolites in the causal gene-hypopituitarism pathway, quantifying both direct and mediation effects. A total of 20 genes associated with hypopituitarism were identified, with RMI2, UBAC1, and GLIPR1 further validated by Bayesian colocalization, and the causal relationship between CHST13, GABPB1-AS1, GLIPR1L2, RNF14, and hypopituitarism was confirmed by summary data-based MR (SMR) and HEIDI analysis. Additionally, 34 serum metabolites and 8 CSF metabolites were causally associated with hypopituitarism. Furthermore, mediation MR analysis demonstrated that 1-Methyl-4-imidazoleacetate was the only mediator, explaining 4.35% (P = 0.049) of the total effect of UBAC1 on increased hypopituitarism susceptibility. This study identified RMI2, UBAC1, CHST13, GABPB1-AS1, GLIPR1L2, RNF14, and GLIPR1 as potentially causal genes in the pathogenesis of hypopituitarism. Furthermore, UBAC1-mediated regulation of serum metabolites may contribute to promoting hypopituitarism progression, indicating that UBAC1 is a candidate gene warranting further functional validation. Future directions could include assessing UBAC1 expression in pituitary/hypothalamus single-cell RNA-seq or in vivo models. - Source: PubMed
Publication date: 2025/11/13
Sun YeshengZhang YingLuan TengfeiLi RuichunCai DongpengZhang Wei - Sulfate plays a critical role in bone health and development. More than 90 sulfate-related genes are highly conserved across mammalian species, but very few of these genes have been linked to adverse bone phenotypes in humans. To extend our knowledge of sulfate-related gene expression dynamics during mineralization, this study leveraged 6 publicly available transcriptomic datasets, covering human osteosarcoma cell line Saos-2 mineralization, 2 mouse calvarial osteoblast mineralization models, vascular smooth muscle cell (VSMC) calcification, and 2 neurogenic heterotopic ossification datasets. We focused on a total of 12 sulfate-related genes that were upregulated during mineralization of Saos-2 cells. Six of these genes (, , , , , and ) were also consistently upregulated during mouse osteoblast and VSMC mineralization. Additionally, 3 genes (, , and ) were upregulated in Saos-2 mineralization but downregulated in mouse primary osteoblasts. , , and were unchanged in the mouse primary cell models. , , , , and also increased in models of heterotopic ossification. We have now identified several genes (, , , , , , and ) that have not previously been considered for adverse bone conditions in humans, suggesting that additional sulfate biology genes may be linked with human skeletal conditions. Network analysis showed large co-expression clusters of genes, including sulfate biology and bone genes, that were upregulated across the calcification time courses. Gene ontology term enrichment analysis demonstrated significant enrichment in terms associated with mineralization, including ossification, bone mineralization, cartilage development, and extracellular matrix organization for these clusters of genes. This study provides a collated list of sulfate-related genes and networks that are associated with mineralization, which will facilitate future functional studies of sulfation pathways associated with bone pathology. - Source: PubMed
Publication date: 2025/08/07
Lee Kun-DiDawson Paul ASummers Kim M - This study determined novel metabolism-related diagnostic biomarkers for ulcer-ative colitis (UC) and assessed their correlation with immune cell infiltration levels. Transcriptome data of UC was downloaded from the Gene Expression Omnibus (GEO) database, metabolism-related genes were summarised from the Gene Set Enrichment Analysis (GSEA) database. A total of 537 metabolism-related differen-tially expressed genes (DEGs) in UC were applied to functional enrichment analy-sis. We processed least absolute shrinkage and selection operator (LASSO) regres-sion analysis and support vector machine-recursive feature elimination (SVM-RFE). We obtained 6 potential metabolism-related diagnostic biomarkers (CHST13, ETNK1, LPCAT1, PDE6A, PLA2G2A, and UGT2A3). Expression patterns and diagnostic ROC curves were depicted in both the training and testing co-horts to verify their diagnostic value. Immune infiltration analysis indicated that UC samples have more abundant infiltration levels of immune cells. Fur-thermore, the upregulated diagnostic biomarkers significantly positively cor-related with B cell memory, T cell CD4 memory activated, dendritic cells ac-tivated, etc., while the downregulated ones mainly significantly positively correlated with mast cells resting, NK cells activated, and macrophages M2. Our study primarily identified 6 metabolism regulators (CHST13, ETNK1, LP-CAT1, PDE6A, PLA2G2A, and UGT2A3) as potential diagnostic biomarkers for UC and determined their correlation with immune infiltration. - Source: PubMed
Duan QilongLiu PengChen HualeiDing YuanyuanXu Xiaoming - Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major global health concern due to its high mortality and resistance to current therapies. Emerging evidence highlights the role of carbohydrate sulfotransferases CHST11 and CHST13 in driving tumor progression, activating MAPK signaling, and mediating chemoresistance. In this study, homology modeling, molecular docking, and molecular dynamics (MD) simulations were used to explore the structural and functional properties of CHST11 and CHST13, key sulfotransferases implicated in HCC. Active site analysis and interaction profiling guided the screening of 60 bioactive compounds, with ascorbic acid as a reference. Capsaicin bound strongly to both CHST11 and CHST13, whereas erlotinib exhibited selective affinity for CHST13. Notably, the CHST13-capsaicin complex demonstrated the most favorable binding energy and structural stability in MD simulations. These findings highlight the distinct dynamic behaviors of both targets and support their potential as druggable proteins in HCC, offering a basis for developing selective therapeutic inhibitors. - Source: PubMed
Publication date: 2025/07/08
Sharma IshaSingh Vinay KumarVyas RajanVerma Malkhey - Stroke is a leading cause of death worldwide, with a lack of effective treatments for improving the prognosis. The aim of the present study was to identify novel therapeutic targets for functional outcome after ischemic stroke . - Source: PubMed
Publication date: 2024/08/09
Zhang Lu-YangChu Yun-HuiYou Yun-FanDong Ming-HaoPang Xiao-WeiChen LianZhu Li-FangYang ShengZhou Luo-QiShang KeDeng GangXiao JunWang WeiQin ChuanTian Dai-Shi