Ask about this productRelated genes to: FAM14A antibody
- Gene:
- IFI27L2 NIH gene
- Name:
- interferon alpha inducible protein 27 like 2
- Previous symbol:
- FAM14A
- Synonyms:
- TLH29
- Chromosome:
- 14q32.12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-25
- Date modifiied:
- 2016-10-11
Related products to: FAM14A antibody
Related articles to: FAM14A antibody
- Interferon alpha-inducible protein 27 like 2A () was initially identified as an interferon-stimulated gene (Isg) involved in host-dependent mechanisms during viral invasion. We have recently shown that the Ifi27l2a protein also plays a critical role in microglia and the spreading of neuroinflammation. However, the detailed mechanisms of action of intracellular and extracellular Ifi27l2a in glial cells, particularly in inflammatory and neurodegenerative diseases, are not yet defined. We now report that systemic inflammation leads to an elevated level of circulating Ifi27l2a in the plasma of lipopolysaccharide (LPS)-treated mice, which is associated with elevated mRNA expression in the brain. Elevated IFI27L2 (human isoform) was also found in plasma of human stroke patients. To test whether extracellular (e.g. secreted) Ifi27l2a can contribute as an autocrine or paracrine inducer of microglial activation and inflammation, we treated microglial cells with recombinant Ifi27l2a (rIfi27l2a). Treatment with rIfi27l2a led to increased expression of proinflammatory cytokines and elevated reactive oxygen species (ROS) levels in microglial cells. These effects resulted from alterations in mitochondrial function and a metabolic shift from oxidative phosphorylation toward glycolysis for ATP synthesis. Additionally, Ifi27l2a led to increased caspase-1 activity, demonstrating that Ifi27l2a causes Nlrp3 inflammasome activation. RNA sequencing revealed that Ifi27l2a mediates transcriptional changes reflecting activated microglia. These data support an extracellular role of Ifi27l2a as a novel cytokine, in which it promotes a phenotypic shift in microglia toward a proinflammatory phenotype. Targeting Ifi27l2a may therefore provide an additional strategy to reduce microglia-mediated inflammation in the brain. - Source: PubMed
Publication date: 2025/09/24
Kim SodamBurrous HavenHarmon ElisabethVance LaurenWu TingAndersohn AlexanderDoan AndreaWolocko DarbyWise ZacharyKitamura YukiJung Joo EunColpo GabrielaCouture LucyBlixt FrankMcCullough LouiseMarrelli SeanKim Gab Seok - Viral nervous necrosis (VNN) is an important viral disease threatening global aquaculture sustainability and affecting over 50 farmed and ecologically important fish species. A major QTL for resistance to VNN has been previously detected in European sea bass, but the underlying causal gene(s) and mutation(s) remain unknown. To identify the mechanisms and genetic factors underpinning resistance to VNN in European sea bass, we employed integrative analyses of multiple functional genomics assays in European sea bass. - Source: PubMed
Publication date: 2025/03/11
Mukiibi RobertFerraresso SerenaFranch RafaellaPeruzza LucaDalla Rovere GiuliaBabbucci MassimilianoBertotto DanielaToffan AnnaPascoli FrancescoFaggion SaraPeñaloza CarolinaTsigenopoulos Costas SHouston Ross DBargelloni LucaRobledo Diego - Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. Neurodegeneration results in excessive neuronal cell death, and cancer emerges from increased proliferation and resistance to cell death. Although most epidemiological studies support an inverse association between the risk for the development of neurodegenerative diseases and cancer, increasing evidence points to a positive correlation between specific types of cancer, like prostate adenocarcinoma (PRAD), and neurodegenerative diseases, like Parkinson's disease (PD). - Source: PubMed
Publication date: 2023/03/15
Liu TingtingYang ZhengjiaLiu ShufenWei Jianshe - Recently, intestinal flora plays a vital role in the occurrence and development of tumors and there is link between cancer immunotherapy and Akkermansia muciniphila (Akk). However, the therapeutic efficacy of Akk in lung cancer remained unclear. Hence, our study is aimed at investigating the antitumor effects of cisplatin (CDDP) combined with Akk on lung cancer. Using the murine lung cancer model by subcutaneously inoculating Lewis lung cancer model, 50 mice were divided into five groups: normal, model, CDDP, CDDP+Akk, and CDDP+antibiotics. After treatment within 5 weeks, compared with the model group, the administered group improved the changes of tumor pathomorphology. Compared with the CDDP group, CDDP combining with Akk slowed down the growth of tumor volume, downregulated the levels of ki-67, p53, and factor-associated suicide (Fas) ligand proteins and upregulated Fas proteins, increased the levels of interferon-, interleukin-6, and tumor necrosis factor-, and suppressed the expression of CD4CD25Foxp3 Treg in mouse peripheral blood and spleen. In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. These results suggested that the therapeutic efficacy of the combined treatment of Akk and CDDP was superior to the only CDDP treatment, which could enhance immune regulation and would be a promising strategy for the treatment of lung cancer. - Source: PubMed
Publication date: 2020/08/07
Chen ZhuoQian XiangChen ShashaFu XiaoxuanMa GuanjunZhang Aiqin - Newcastle disease is considered the number one disease constraint to poultry production in low and middle-income countries, however poultry that is raised in resource-poor areas often experience multiple environmental challenges. Heat stress has a negative impact on production, and immune response to pathogens can be negatively modulated by heat stress. Candidate genes and regions chosen for this study were based on previously reported associations with response to immune stimulants, pathogens, or heat, including: , , , MHC-B (major histocompatibility complex, gene complex), , , , , , , , , , and . Chickens of a commercial egg-laying line were infected with a lentogenic strain of NDV (Newcastle disease virus); half the birds were maintained at thermoneutral temperature and the other half were exposed to high ambient temperature before the NDV challenge and throughout the remainder of the study. Phenotypic responses to heat, to NDV, or to heat + NDV were measured. Selected SNPs (single nucleotide polymorphisms) within 14 target genes or regions were genotyped; and genotype effects on phenotypic responses to NDV or heat + NDV were tested in each individual treatment group and the combined groups. Seventeen significant haplotype effects, among seven genes and seven phenotypes, were detected for response to NDV or heat or NDV + heat. These findings identify specific genetic variants that are associated with response to heat and/or NDV which may be useful in the genetic improvement of chickens to perform favorably when faced with pathogens and heat stress. - Source: PubMed
Publication date: 2018/11/19
Rowland KayleeSaelao PerotWang YingFulton Janet ELiebe Grant NMcCarron Amy MWolc AnnaGallardo Rodrigo AKelly TerraZhou HuaijunDekkers Jack C MLamont Susan J